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- W2097153088 abstract "Activation of host innate antiviral responses are mediated by retinoic-acid inducible gene I ( RIG-I)-like receptors, RIG-I and melanoma differentiation-associated gene 5, and TLRs 3, 7, 8 and 9, recognising different types of viral nucleic acids. The major components of the RIG-I- and TLR pathways have putatively been identified, but previously unrecognised kinases may contribute to virus infection-induced activation of the IFN response. Here, we screened a human kinase cDNA library, termed the kinome, using an IFN-λ1 promoter-driven luciferase reporter assay in HEK293 cells during Sendai virus infection. Of the 568 kinases analysed, nearly 50 enhanced IFN-λ1 gene expression at least twofold in response to Sendai virus infection. The best activators were FYN ( FYN oncogene related to SRC, FGR, YES), serine/threonine kinase 24, activin A receptor type 1 and SRPK1 (SFRS protein kinase 1). These kinases enhanced RIG-I-dependent IFN-λ1 promoter activation via IFN-stimulated response and NF-κB elements, as confirmed using mutant IFN-λ1 promoter constructs. FYN and SRPK1 enhanced IFN-λ1 and CXCL10 protein production via the RIG-I pathway, and stimulated RIG-I and MyD88-dependent phosphorylation of IRF3 and IRF7 transcription factors, respectively. We conclude that several previously unrecognised kinases, particularly FYN and SRPK1, positively regulate IFN-λ1 and similarly regulated cytokine and chemokine genes during viral infection." @default.
- W2097153088 created "2016-06-24" @default.
- W2097153088 creator A5001440882 @default.
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- W2097153088 creator A5042449762 @default.
- W2097153088 creator A5056577621 @default.
- W2097153088 creator A5067851120 @default.
- W2097153088 date "2013-02-12" @default.
- W2097153088 modified "2023-10-01" @default.
- W2097153088 title "Human kinome analysis reveals novel kinases contributing to virus infection and retinoic-acid inducible gene I-induced type I and type III <i>IFN</i> gene expression" @default.
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- W2097153088 cites W1759218048 @default.
- W2097153088 cites W1860159973 @default.
- W2097153088 cites W1966772446 @default.
- W2097153088 cites W1973646620 @default.
- W2097153088 cites W1976209243 @default.
- W2097153088 cites W1980829155 @default.
- W2097153088 cites W1986567779 @default.
- W2097153088 cites W1986918332 @default.
- W2097153088 cites W1987009823 @default.
- W2097153088 cites W1990599681 @default.
- W2097153088 cites W1992336935 @default.
- W2097153088 cites W1998237259 @default.
- W2097153088 cites W1999439773 @default.
- W2097153088 cites W2012836529 @default.
- W2097153088 cites W2028575270 @default.
- W2097153088 cites W2030247364 @default.
- W2097153088 cites W2031259230 @default.
- W2097153088 cites W2034275921 @default.
- W2097153088 cites W2044937124 @default.
- W2097153088 cites W2047984410 @default.
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- W2097153088 cites W2058008662 @default.
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- W2097153088 cites W2064024180 @default.
- W2097153088 cites W2066298786 @default.
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- W2097153088 cites W2071670416 @default.
- W2097153088 cites W2076971119 @default.
- W2097153088 cites W2080568795 @default.
- W2097153088 cites W2080815378 @default.
- W2097153088 cites W2082620735 @default.
- W2097153088 cites W2083733004 @default.
- W2097153088 cites W2084880831 @default.
- W2097153088 cites W2088456748 @default.
- W2097153088 cites W2105047045 @default.
- W2097153088 cites W2110217901 @default.
- W2097153088 cites W2112269300 @default.
- W2097153088 cites W2112294328 @default.
- W2097153088 cites W2112812632 @default.
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- W2097153088 cites W2123644043 @default.
- W2097153088 cites W2125354036 @default.
- W2097153088 cites W2125566625 @default.
- W2097153088 cites W2127473178 @default.
- W2097153088 cites W2130576390 @default.
- W2097153088 cites W2135401259 @default.
- W2097153088 cites W2138401012 @default.
- W2097153088 cites W2140191892 @default.
- W2097153088 cites W2141137217 @default.
- W2097153088 cites W2142116112 @default.
- W2097153088 cites W2143516276 @default.
- W2097153088 cites W2144787399 @default.
- W2097153088 cites W2148556164 @default.
- W2097153088 cites W2148690764 @default.
- W2097153088 cites W2154153541 @default.
- W2097153088 cites W2157135427 @default.
- W2097153088 cites W2159803503 @default.
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- W2097153088 cites W2444384637 @default.
- W2097153088 cites W4233800959 @default.
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- W2097153088 doi "https://doi.org/10.1177/1753425912473345" @default.
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- W2097153088 hasPublicationYear "2013" @default.
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