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- W2097154098 abstract "SMAD4 is the common intracellular mediator of the TGF-β superfamily pathway. Inactivation of SMAD4 has been linked to pancreatic adenocarcinoma, non-small cell lung cancer, colorectal cancer, and germline mutations cause the autosomal dominant cancer syndrome Juvenile Polyposis (JP). The location of the SMAD4 promoter has not been clearly defined, but knowledge of its genomic structure suggests it most likely lies upstream of 2 non-coding exons rather than the first coding exon, as previously thought. Since little is known about the transcription regulatory mechanisms of this important tumor suppressor gene, we set out to identify and characterize the promoter of SMAD4." @default.
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- W2097154098 date "2009-02-01" @default.
- W2097154098 modified "2023-09-25" @default.
- W2097154098 title "49: Discovery of SMAD4 Promoter 16 Kb Upstream From its Translation Start Site" @default.
- W2097154098 doi "https://doi.org/10.1016/j.jss.2008.11.059" @default.
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