FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097183790> ?p ?o ?g. }

• W2097183790 endingPage "226" @default.
• W2097183790 startingPage "218" @default.
• W2097183790 abstract "Patients infected with human immunodeficiency virus (HIV) have a higher risk of developing major depressive disorder (MDD) than the general population. Immunophilins FKBP51 and FKBP52 are expressed in cortical neurons and regulate the function of the glucocorticoid receptor (GR). Previous reports have shown that genetic variants in the FKBP5 gene encoding FKBP51 are linked to psychiatric disorders. We sought to determine whether immunophilins are upregulated in HIV infection. To determine whether FKBP52 and FKBP51 are associated with MDD and/or HIV, we compared protein and gene expression in autopsy tissues from the frontal cortical gray matter. The study cases were divided into five groups: control, MDD, MDD with psychosis, HIV+, and HIV+ with MDD. Gene expression and protein levels were determined by real-time PCR and Western blot analysis of fresh frozen tissues. Genotyping of previously published alleles of the FKBP5 gene was also performed. We found correlation of upregulation of both immunophilins in the HIV-infected groups. In the HIV+ population with MDD, FKBP4 expression is significantly higher while FKBP5 is more variable. After analyzing the FKBP5 gene for single nucleotide polymorphisms, we found that rs3800373 CC genotype is more frequent in the MDD and MDD/Psychosis groups. We hypothesized that the levels of FKBP51, as modulator of the nuclear translocation of GR, would be lower in MDD. Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV+MDD but not to HIV without MDD." @default.
• W2097183790 created "2016-06-24" @default.
• W2097183790 creator A5005415150 @default.
• W2097183790 creator A5026584892 @default.
• W2097183790 creator A5032460960 @default.
• W2097183790 creator A5036105465 @default.
• W2097183790 creator A5049509802 @default.
• W2097183790 creator A5074775445 @default.
• W2097183790 creator A5077494625 @default.
• W2097183790 creator A5083767830 @default.
• W2097183790 creator A5086802508 @default.
• W2097183790 date "2009-02-06" @default.
• W2097183790 modified "2023-09-27" @default.
• W2097183790 title "Differential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder" @default.
• W2097183790 cites W1709405361 @default.
• W2097183790 cites W1937683220 @default.
• W2097183790 cites W1967603109 @default.
• W2097183790 cites W1974793156 @default.
• W2097183790 cites W1978146427 @default.
• W2097183790 cites W1981456658 @default.
• W2097183790 cites W1985339794 @default.
• W2097183790 cites W1992927495 @default.
• W2097183790 cites W1995078933 @default.
• W2097183790 cites W2009900057 @default.
• W2097183790 cites W2026298348 @default.
• W2097183790 cites W2027689592 @default.
• W2097183790 cites W2065295359 @default.
• W2097183790 cites W2070045694 @default.
• W2097183790 cites W2072920261 @default.
• W2097183790 cites W2084399551 @default.
• W2097183790 cites W2087966784 @default.
• W2097183790 cites W2092946317 @default.
• W2097183790 cites W2110921107 @default.
• W2097183790 cites W2126258512 @default.
• W2097183790 cites W2149645046 @default.
• W2097183790 cites W2150658204 @default.
• W2097183790 cites W2152690383 @default.
• W2097183790 cites W2153648492 @default.
• W2097183790 cites W2166401337 @default.
• W2097183790 doi "https://doi.org/10.1007/s11481-009-9146-6" @default.
• W2097183790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2929573" @default.
• W2097183790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19199039" @default.
• W2097183790 hasPublicationYear "2009" @default.
• W2097183790 type Work @default.
• W2097183790 sameAs 2097183790 @default.
• W2097183790 citedByCount "64" @default.
• W2097183790 countsByYear W20971837902012 @default.
• W2097183790 countsByYear W20971837902013 @default.
• W2097183790 countsByYear W20971837902014 @default.
• W2097183790 countsByYear W20971837902015 @default.
• W2097183790 countsByYear W20971837902016 @default.
• W2097183790 countsByYear W20971837902017 @default.
• W2097183790 countsByYear W20971837902018 @default.
• W2097183790 countsByYear W20971837902019 @default.
• W2097183790 countsByYear W20971837902020 @default.
• W2097183790 countsByYear W20971837902021 @default.
• W2097183790 countsByYear W20971837902022 @default.
• W2097183790 countsByYear W20971837902023 @default.
• W2097183790 crossrefType "journal-article" @default.
• W2097183790 hasAuthorship W2097183790A5005415150 @default.
• W2097183790 hasAuthorship W2097183790A5026584892 @default.
• W2097183790 hasAuthorship W2097183790A5032460960 @default.
• W2097183790 hasAuthorship W2097183790A5036105465 @default.
• W2097183790 hasAuthorship W2097183790A5049509802 @default.
• W2097183790 hasAuthorship W2097183790A5074775445 @default.
• W2097183790 hasAuthorship W2097183790A5077494625 @default.
• W2097183790 hasAuthorship W2097183790A5083767830 @default.
• W2097183790 hasAuthorship W2097183790A5086802508 @default.
• W2097183790 hasBestOaLocation W20971837901 @default.
• W2097183790 hasConcept C104317684 @default.
• W2097183790 hasConcept C134018914 @default.
• W2097183790 hasConcept C2779144063 @default.
• W2097183790 hasConcept C2780051608 @default.
• W2097183790 hasConcept C2908647359 @default.
• W2097183790 hasConcept C54355233 @default.
• W2097183790 hasConcept C59493245 @default.
• W2097183790 hasConcept C71924100 @default.
• W2097183790 hasConcept C78150878 @default.
• W2097183790 hasConcept C86803240 @default.
• W2097183790 hasConcept C99454951 @default.
• W2097183790 hasConceptScore W2097183790C104317684 @default.
• W2097183790 hasConceptScore W2097183790C134018914 @default.
• W2097183790 hasConceptScore W2097183790C2779144063 @default.
• W2097183790 hasConceptScore W2097183790C2780051608 @default.
• W2097183790 hasConceptScore W2097183790C2908647359 @default.
• W2097183790 hasConceptScore W2097183790C54355233 @default.
• W2097183790 hasConceptScore W2097183790C59493245 @default.
• W2097183790 hasConceptScore W2097183790C71924100 @default.
• W2097183790 hasConceptScore W2097183790C78150878 @default.
• W2097183790 hasConceptScore W2097183790C86803240 @default.
• W2097183790 hasConceptScore W2097183790C99454951 @default.
• W2097183790 hasIssue "2" @default.
• W2097183790 hasLocation W20971837901 @default.
• W2097183790 hasLocation W20971837902 @default.
• W2097183790 hasLocation W20971837903 @default.
• W2097183790 hasLocation W20971837904 @default.
• W2097183790 hasLocation W20971837905 @default.
• W2097183790 hasOpenAccess W2097183790 @default.

• next