Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097184076> ?p ?o ?g. }
- W2097184076 endingPage "E484" @default.
- W2097184076 startingPage "E477" @default.
- W2097184076 abstract "Reinnervation of denervated muscle by motor neurons transplanted into the peripheral nerve may provide the potential to excite muscles artificially with functional electrical stimulation (FES). Here we investigated whether transplantation of embryonic motor neurons into peripheral nerve combined with FES restored functional muscle activity in adult Fischer 344 rats after transection of the sciatic nerve. One week after sciatic nerve transection, cell culture medium containing (cell transplantation group, n = 6) or lacking (surgical control group, n = 6) dissociated embryonic spinal neurons was injected into the distal stump of the tibial and peroneal nerves. Electrophysiological and tissue analyses were performed in the cell transplantation and surgical control groups 12 weeks after transplantation, as well as a in naïve control group (n = 6) that received no surgery. In the cell transplantation group, ankle angle was measured during gait, with and without FES of the peroneal nerve. Ankle angle at mid-swing was more flexed during gait with FES (26.6 ± 8.7°) than gait without FES (51.4 ± 12.8°, p = 0.011), indicating that transplantated motor neurons in conjunction with FES restored ankle flexion in gait, even though no neural connection between central nervous system and muscle was present. These results indicate that transplantation of embryonic motor neurons into peripheral nerve combined with FES can provide a novel treatment strategy for paralysed muscles. Copyright © 2013 John Wiley & Sons, Ltd." @default.
- W2097184076 created "2016-06-24" @default.
- W2097184076 creator A5003797388 @default.
- W2097184076 creator A5023049435 @default.
- W2097184076 creator A5027510626 @default.
- W2097184076 creator A5057443545 @default.
- W2097184076 creator A5066076986 @default.
- W2097184076 creator A5067454062 @default.
- W2097184076 date "2013-10-30" @default.
- W2097184076 modified "2023-09-24" @default.
- W2097184076 title "Transplantation of embryonic motor neurons into peripheral nerve combined with functional electrical stimulation restores functional muscle activity in the rat sciatic nerve transection model" @default.
- W2097184076 cites W108547021 @default.
- W2097184076 cites W1605791286 @default.
- W2097184076 cites W1977208459 @default.
- W2097184076 cites W1987057771 @default.
- W2097184076 cites W1993103207 @default.
- W2097184076 cites W1997894859 @default.
- W2097184076 cites W2000308123 @default.
- W2097184076 cites W2001924186 @default.
- W2097184076 cites W2002699122 @default.
- W2097184076 cites W2010150943 @default.
- W2097184076 cites W2012020530 @default.
- W2097184076 cites W2018288956 @default.
- W2097184076 cites W2033803161 @default.
- W2097184076 cites W2040660429 @default.
- W2097184076 cites W2049492867 @default.
- W2097184076 cites W2052086914 @default.
- W2097184076 cites W2060053148 @default.
- W2097184076 cites W2061285108 @default.
- W2097184076 cites W2065063860 @default.
- W2097184076 cites W2077085462 @default.
- W2097184076 cites W2096059220 @default.
- W2097184076 cites W2097898942 @default.
- W2097184076 cites W2113657338 @default.
- W2097184076 cites W2129721270 @default.
- W2097184076 cites W2133494168 @default.
- W2097184076 cites W2149038956 @default.
- W2097184076 cites W2167498165 @default.
- W2097184076 cites W2183534138 @default.
- W2097184076 cites W23271243 @default.
- W2097184076 cites W30465602 @default.
- W2097184076 cites W4213263913 @default.
- W2097184076 doi "https://doi.org/10.1002/term.1844" @default.
- W2097184076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24668934" @default.
- W2097184076 hasPublicationYear "2013" @default.
- W2097184076 type Work @default.
- W2097184076 sameAs 2097184076 @default.
- W2097184076 citedByCount "16" @default.
- W2097184076 countsByYear W20971840762015 @default.
- W2097184076 countsByYear W20971840762018 @default.
- W2097184076 countsByYear W20971840762019 @default.
- W2097184076 countsByYear W20971840762020 @default.
- W2097184076 countsByYear W20971840762021 @default.
- W2097184076 countsByYear W20971840762022 @default.
- W2097184076 crossrefType "journal-article" @default.
- W2097184076 hasAuthorship W2097184076A5003797388 @default.
- W2097184076 hasAuthorship W2097184076A5023049435 @default.
- W2097184076 hasAuthorship W2097184076A5027510626 @default.
- W2097184076 hasAuthorship W2097184076A5057443545 @default.
- W2097184076 hasAuthorship W2097184076A5066076986 @default.
- W2097184076 hasAuthorship W2097184076A5067454062 @default.
- W2097184076 hasConcept C105702510 @default.
- W2097184076 hasConcept C126322002 @default.
- W2097184076 hasConcept C141071460 @default.
- W2097184076 hasConcept C24998067 @default.
- W2097184076 hasConcept C2776664896 @default.
- W2097184076 hasConcept C2777766275 @default.
- W2097184076 hasConcept C2778640784 @default.
- W2097184076 hasConcept C2779649809 @default.
- W2097184076 hasConcept C2781149210 @default.
- W2097184076 hasConcept C2911091166 @default.
- W2097184076 hasConcept C46762472 @default.
- W2097184076 hasConcept C71924100 @default.
- W2097184076 hasConceptScore W2097184076C105702510 @default.
- W2097184076 hasConceptScore W2097184076C126322002 @default.
- W2097184076 hasConceptScore W2097184076C141071460 @default.
- W2097184076 hasConceptScore W2097184076C24998067 @default.
- W2097184076 hasConceptScore W2097184076C2776664896 @default.
- W2097184076 hasConceptScore W2097184076C2777766275 @default.
- W2097184076 hasConceptScore W2097184076C2778640784 @default.
- W2097184076 hasConceptScore W2097184076C2779649809 @default.
- W2097184076 hasConceptScore W2097184076C2781149210 @default.
- W2097184076 hasConceptScore W2097184076C2911091166 @default.
- W2097184076 hasConceptScore W2097184076C46762472 @default.
- W2097184076 hasConceptScore W2097184076C71924100 @default.
- W2097184076 hasFunder F4320320912 @default.
- W2097184076 hasIssue "10" @default.
- W2097184076 hasLocation W20971840761 @default.
- W2097184076 hasLocation W20971840762 @default.
- W2097184076 hasOpenAccess W2097184076 @default.
- W2097184076 hasPrimaryLocation W20971840761 @default.
- W2097184076 hasRelatedWork W1813537150 @default.
- W2097184076 hasRelatedWork W1949085980 @default.
- W2097184076 hasRelatedWork W1971742512 @default.
- W2097184076 hasRelatedWork W1998634577 @default.
- W2097184076 hasRelatedWork W1999507005 @default.
- W2097184076 hasRelatedWork W2033865597 @default.
- W2097184076 hasRelatedWork W2096866331 @default.