FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097184485> ?p ?o ?g. }

• W2097184485 endingPage "718" @default.
• W2097184485 startingPage "711" @default.
• W2097184485 abstract "Leptin, a protein encoded by the obese gene, is produced by adipocytes and released into the bloodstream. In obese humans, serum leptin levels are increased and correlate with the individual's body mass index and blood pressure. Elevated serum concentrations of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen, were also observed in obese subjects. The pathomechanisms underlying this ET-1 increase in obesity are poorly understood. In the present study, we investigated the influence of the ob gene product leptin on the expression of ET-1 in human umbilical vein endothelial cells (HUVECs). Binding studies using (125)I-radiolabeled leptin revealed high- and low-affinity leptin binding sites on HUVECs (Kd1=13.1+/-3.1 nmol/L and Kd2=1390+/-198 nmol/L, respectively), mediating a time- and dose-dependent increase of ET-1 mRNA expression and protein secretion after incubation of HUVECs with leptin. This leptin-induced ET-1 expression was inhibited by preincubation of HUVECs with 0.75 micromol/L antisense phosphorothioate oligonucleotides directed against the leptin receptor Ob-Rb. Furthermore, after incubation with leptin, increased nuclear staining of c-fos and c-jun, the major components of the transcription factor AP-1, and increased AP-1 DNA binding were observed. Transient transfection studies with ET-1 promoter constructs showed that leptin-induced promoter activity was abolished in the absence of AP-1 binding sites or by cotransfection with a plasmid overexpressing a mutated jun, which is able to bind c-fos but not DNA. Thus, leptin upregulates ET-1 production in HUVECs via a mechanism potentially involving jun binding members of the bZIP family." @default.
• W2097184485 created "2016-06-24" @default.
• W2097184485 creator A5004089125 @default.
• W2097184485 creator A5005313310 @default.
• W2097184485 creator A5007415930 @default.
• W2097184485 creator A5015899523 @default.
• W2097184485 creator A5046156507 @default.
• W2097184485 creator A5058100095 @default.
• W2097184485 creator A5068015753 @default.
• W2097184485 creator A5082163795 @default.
• W2097184485 creator A5087032297 @default.
• W2097184485 date "2002-04-05" @default.
• W2097184485 modified "2023-10-13" @default.
• W2097184485 title "Leptin Induces Endothelin-1 in Endothelial Cells In Vitro" @default.
• W2097184485 cites W1548437752 @default.
• W2097184485 cites W1607853670 @default.
• W2097184485 cites W1898391394 @default.
• W2097184485 cites W1974033843 @default.
• W2097184485 cites W1979286266 @default.
• W2097184485 cites W1980666218 @default.
• W2097184485 cites W1987603981 @default.
• W2097184485 cites W1996713062 @default.
• W2097184485 cites W2009594902 @default.
• W2097184485 cites W2013583119 @default.
• W2097184485 cites W2014093920 @default.
• W2097184485 cites W2014163208 @default.
• W2097184485 cites W2025846514 @default.
• W2097184485 cites W2042463439 @default.
• W2097184485 cites W2053965920 @default.
• W2097184485 cites W2054100350 @default.
• W2097184485 cites W2055689111 @default.
• W2097184485 cites W2059748176 @default.
• W2097184485 cites W2060682066 @default.
• W2097184485 cites W2069038722 @default.
• W2097184485 cites W2081494990 @default.
• W2097184485 cites W2094415073 @default.
• W2097184485 cites W2095308289 @default.
• W2097184485 cites W2106780768 @default.
• W2097184485 cites W2109591901 @default.
• W2097184485 cites W2111232488 @default.
• W2097184485 cites W2126426760 @default.
• W2097184485 cites W2126879889 @default.
• W2097184485 cites W2144465852 @default.
• W2097184485 cites W2155854462 @default.
• W2097184485 cites W2157603347 @default.
• W2097184485 cites W2283638085 @default.
• W2097184485 cites W2334337188 @default.
• W2097184485 cites W2336184170 @default.
• W2097184485 cites W2336208433 @default.
• W2097184485 cites W2341398312 @default.
• W2097184485 cites W2405272203 @default.
• W2097184485 cites W294674092 @default.
• W2097184485 doi "https://doi.org/10.1161/01.res.0000014226.74709.90" @default.
• W2097184485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11934840" @default.
• W2097184485 hasPublicationYear "2002" @default.
• W2097184485 type Work @default.
• W2097184485 sameAs 2097184485 @default.
• W2097184485 citedByCount "206" @default.
• W2097184485 countsByYear W20971844852012 @default.
• W2097184485 countsByYear W20971844852013 @default.
• W2097184485 countsByYear W20971844852014 @default.
• W2097184485 countsByYear W20971844852015 @default.
• W2097184485 countsByYear W20971844852016 @default.
• W2097184485 countsByYear W20971844852017 @default.
• W2097184485 countsByYear W20971844852018 @default.
• W2097184485 countsByYear W20971844852019 @default.
• W2097184485 countsByYear W20971844852020 @default.
• W2097184485 countsByYear W20971844852021 @default.
• W2097184485 countsByYear W20971844852022 @default.
• W2097184485 countsByYear W20971844852023 @default.
• W2097184485 crossrefType "journal-article" @default.
• W2097184485 hasAuthorship W2097184485A5004089125 @default.
• W2097184485 hasAuthorship W2097184485A5005313310 @default.
• W2097184485 hasAuthorship W2097184485A5007415930 @default.
• W2097184485 hasAuthorship W2097184485A5015899523 @default.
• W2097184485 hasAuthorship W2097184485A5046156507 @default.
• W2097184485 hasAuthorship W2097184485A5058100095 @default.
• W2097184485 hasAuthorship W2097184485A5068015753 @default.
• W2097184485 hasAuthorship W2097184485A5082163795 @default.
• W2097184485 hasAuthorship W2097184485A5087032297 @default.
• W2097184485 hasBestOaLocation W20971844851 @default.
• W2097184485 hasConcept C104317684 @default.
• W2097184485 hasConcept C126322002 @default.
• W2097184485 hasConcept C134018914 @default.
• W2097184485 hasConcept C14372207 @default.
• W2097184485 hasConcept C149601957 @default.
• W2097184485 hasConcept C153911025 @default.
• W2097184485 hasConcept C170493617 @default.
• W2097184485 hasConcept C185592680 @default.
• W2097184485 hasConcept C202751555 @default.
• W2097184485 hasConcept C2777411675 @default.
• W2097184485 hasConcept C2780613262 @default.
• W2097184485 hasConcept C511355011 @default.
• W2097184485 hasConcept C54009773 @default.
• W2097184485 hasConcept C55493867 @default.
• W2097184485 hasConcept C71924100 @default.
• W2097184485 hasConcept C86803240 @default.
• W2097184485 hasConceptScore W2097184485C104317684 @default.

• next