FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097188111> ?p ?o ?g. }

• W2097188111 endingPage "1536" @default.
• W2097188111 startingPage "1527" @default.
• W2097188111 abstract "Thick filaments in striated muscle are myosin polymers with a length and diameter that depend on the fibre type. In invertebrates, the length of the thick filaments varies widely in different muscles and additional proteins control filament assembly. Thick filaments in asynchronous insect flight muscle have an extremely regular structure, which is likely to be essential for the oscillatory contraction of these muscles. The factors controlling the assembly of thick filaments in insect flight muscle are not known. We previously identified a thick filament core protein, zeelin 1, in Lethocerus flight and non-flight muscles. This has been sequenced, and the corresponding proteins in Drosophila and Anopheles have been identified. The protein has been re-named myofilin. Zeelin 2, which is on the outside of Lethocerus flight muscle thick filaments, has been sequenced and because of the similarity to Drosophila flightin, is re-named flightin. In Drosophila flight muscle, myofilin has a molecular weight of 20 kDa and is one of five isoforms produced from a single gene. In situ hybridisation of Drosophila embryos showed that myofilin RNA is first expressed late in embryogenesis at stage 15, a little later than myosin. Antibody to myofilin labelled the entire A-band, except for the H-zone, in cryosections of flight and non-flight muscle. The periodicity of myofilin in Drosophila flight muscle thick filaments was found to be 30 nm by measuring the spacing of gold particles in labelled cryosections; this is about twice the 14.5 nm spacing of myosin molecules. The molar ratio of myofilin to myosin in indirect flight muscle is 1:2, which is the same as that of flightin. We propose a model for the association of these proteins in thick filaments, which is consistent with the periodicity and stoichiometry. Myofilin is probably needed for filament assembly in all muscles, and flightin for stability of flight muscle thick filaments in adult flies." @default.
• W2097188111 created "2016-06-24" @default.
• W2097188111 creator A5012986583 @default.
• W2097188111 creator A5013736594 @default.
• W2097188111 creator A5017725925 @default.
• W2097188111 creator A5022323599 @default.
• W2097188111 creator A5024110443 @default.
• W2097188111 creator A5034199564 @default.
• W2097188111 creator A5046198525 @default.
• W2097188111 creator A5067693387 @default.
• W2097188111 date "2005-04-01" @default.
• W2097188111 modified "2023-10-13" @default.
• W2097188111 title "Myofilin, a protein in the thick filaments of insect muscle" @default.
• W2097188111 cites W1212402145 @default.
• W2097188111 cites W1604889430 @default.
• W2097188111 cites W1806301938 @default.
• W2097188111 cites W1837664766 @default.
• W2097188111 cites W1971155870 @default.
• W2097188111 cites W1976367723 @default.
• W2097188111 cites W1990697342 @default.
• W2097188111 cites W1994591092 @default.
• W2097188111 cites W2012203267 @default.
• W2097188111 cites W2012506955 @default.
• W2097188111 cites W2022791998 @default.
• W2097188111 cites W2026080348 @default.
• W2097188111 cites W2050228088 @default.
• W2097188111 cites W2063528888 @default.
• W2097188111 cites W2067440334 @default.
• W2097188111 cites W2069353366 @default.
• W2097188111 cites W2070322655 @default.
• W2097188111 cites W2083184295 @default.
• W2097188111 cites W2083668285 @default.
• W2097188111 cites W2087910069 @default.
• W2097188111 cites W2091857663 @default.
• W2097188111 cites W2093217688 @default.
• W2097188111 cites W2093844012 @default.
• W2097188111 cites W2107955530 @default.
• W2097188111 cites W2116919891 @default.
• W2097188111 cites W2118202513 @default.
• W2097188111 cites W2121609831 @default.
• W2097188111 cites W2132581521 @default.
• W2097188111 cites W2145829966 @default.
• W2097188111 cites W2161729406 @default.
• W2097188111 cites W2171345563 @default.
• W2097188111 cites W2181907140 @default.
• W2097188111 cites W2403074331 @default.
• W2097188111 cites W87956164 @default.
• W2097188111 doi "https://doi.org/10.1242/jcs.02281" @default.
• W2097188111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15769842" @default.
• W2097188111 hasPublicationYear "2005" @default.
• W2097188111 type Work @default.
• W2097188111 sameAs 2097188111 @default.
• W2097188111 citedByCount "52" @default.
• W2097188111 countsByYear W20971881112012 @default.
• W2097188111 countsByYear W20971881112013 @default.
• W2097188111 countsByYear W20971881112014 @default.
• W2097188111 countsByYear W20971881112015 @default.
• W2097188111 countsByYear W20971881112016 @default.
• W2097188111 countsByYear W20971881112017 @default.
• W2097188111 countsByYear W20971881112018 @default.
• W2097188111 countsByYear W20971881112019 @default.
• W2097188111 countsByYear W20971881112020 @default.
• W2097188111 countsByYear W20971881112021 @default.
• W2097188111 countsByYear W20971881112022 @default.
• W2097188111 countsByYear W20971881112023 @default.
• W2097188111 crossrefType "journal-article" @default.
• W2097188111 hasAuthorship W2097188111A5012986583 @default.
• W2097188111 hasAuthorship W2097188111A5013736594 @default.
• W2097188111 hasAuthorship W2097188111A5017725925 @default.
• W2097188111 hasAuthorship W2097188111A5022323599 @default.
• W2097188111 hasAuthorship W2097188111A5024110443 @default.
• W2097188111 hasAuthorship W2097188111A5034199564 @default.
• W2097188111 hasAuthorship W2097188111A5046198525 @default.
• W2097188111 hasAuthorship W2097188111A5067693387 @default.
• W2097188111 hasBestOaLocation W20971881111 @default.
• W2097188111 hasConcept C104317684 @default.
• W2097188111 hasConcept C105702510 @default.
• W2097188111 hasConcept C12554922 @default.
• W2097188111 hasConcept C125705527 @default.
• W2097188111 hasConcept C127413603 @default.
• W2097188111 hasConcept C14228908 @default.
• W2097188111 hasConcept C146978453 @default.
• W2097188111 hasConcept C2777314717 @default.
• W2097188111 hasConcept C2777612826 @default.
• W2097188111 hasConcept C53345823 @default.
• W2097188111 hasConcept C55493867 @default.
• W2097188111 hasConcept C59822182 @default.
• W2097188111 hasConcept C6997183 @default.
• W2097188111 hasConcept C7301908 @default.
• W2097188111 hasConcept C86803240 @default.
• W2097188111 hasConcept C95444343 @default.
• W2097188111 hasConcept C97257150 @default.
• W2097188111 hasConceptScore W2097188111C104317684 @default.
• W2097188111 hasConceptScore W2097188111C105702510 @default.
• W2097188111 hasConceptScore W2097188111C12554922 @default.
• W2097188111 hasConceptScore W2097188111C125705527 @default.
• W2097188111 hasConceptScore W2097188111C127413603 @default.
• W2097188111 hasConceptScore W2097188111C14228908 @default.

• next