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• W2097191518 abstract "We report on an in vivo single-molecule study of the signaling kinetics of G protein-coupled receptors (GPCR) performed using the neurokinin 1 receptor (NK1R) as a representative member. The NK1R signaling cascade is triggered by the specific binding of a fluorescently labeled agonist, substance P (SP). The diffusion of single receptor-ligand complexes in plasma membrane of living HEK 293 cells is imaged using fast single-molecule wide-field fluorescence microscopy at 100 ms time resolution. Diffusion trajectories are obtained which show intra- and intertrace heterogeneity in the diffusion mode. To investigate universal patterns in the diffusion trajectories we take the ligand-binding event as the common starting point. This synchronization allows us to observe changes in the character of the ligand-receptor-complex diffusion. Specifically, we find that the diffusion of ligand-receptor complexes is slowed down significantly and becomes more constrained as a function of time during the first 1000 ms. The decelerated and more constrained diffusion is attributed to an increasing interaction of the GPCR with cellular structures after the ligand-receptor complex is formed." @default.
• W2097191518 created "2016-06-24" @default.
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• W2097191518 date "2005-08-05" @default.
• W2097191518 modified "2023-10-11" @default.
• W2097191518 title "Kinetics of the Initial Steps of G Protein-Coupled Receptor-Mediated Cellular Signaling Revealed by Single-Molecule Imaging" @default.
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• W2097191518 doi "https://doi.org/10.1002/cphc.200500111" @default.
• W2097191518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16082665" @default.
• W2097191518 hasPublicationYear "2005" @default.
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