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• W2097202487 abstract "Abstract Background Effective tight glycemic control (TGC) can improve outcomes in critical care patients, but it is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between insulin concentration and insulin-mediated glucose disposal. Hence, variability of insulin sensitivity can cause variable glycemia. This study quantifies and compares the daily evolution of insulin sensitivity level and variability for critical care patients receiving TGC. Methods This is a retrospective analysis of data from the SPRINT TGC study involving patients admitted to a mixed medical-surgical ICU between August 2005 and May 2007. Only patients who commenced TGC within 12 hours of ICU admission and spent at least 24 hours on the SPRINT protocol were included (N = 164). Model-based insulin sensitivity ( SI ) was identified each hour. Absolute level and hour-to-hour percent changes in SI were assessed on cohort and per-patient bases. Levels and variability of SI were compared over time on 24-hour and 6-hour timescales for the first 4 days of ICU stay. Results Cohort and per-patient median SI levels increased by 34% and 33% ( p < 0.001) between days 1 and 2 of ICU stay. Concomitantly, cohort and per-patient SI variability decreased by 32% and 36% ( p < 0.001). For 72% of the cohort, median SI on day 2 was higher than on day 1. The day 1–2 results are the only clear, statistically significant trends across both analyses. Analysis of the first 24 hours using 6-hour blocks of SI data showed that most of the improvement in insulin sensitivity level and variability seen between days 1 and 2 occurred during the first 12–18 hours of day 1. Conclusions Critically ill patients have significantly lower and more variable insulin sensitivity on day 1 than later in their ICU stay and particularly during the first 12 hours. This rapid improvement is likely due to the decline of counter-regulatory hormones as the acute phase of critical illness progresses. Clinically, these results suggest that while using TGC protocols with patients during their first few days of ICU stay, extra care should be afforded. Increased measurement frequency, higher target glycemic bands, conservative insulin dosing, and modulation of carbohydrate nutrition should be considered to minimize safely the outcome glycemic variability and reduce the risk of hypoglycemia." @default.
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• W2097202487 date "2012-06-15" @default.
• W2097202487 modified "2023-10-02" @default.
• W2097202487 title "Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control" @default.
• W2097202487 cites W1966344978 @default.
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• W2097202487 cites W1971436236 @default.
• W2097202487 cites W1971638892 @default.
• W2097202487 cites W1976085510 @default.
• W2097202487 cites W1978864042 @default.
• W2097202487 cites W1980717583 @default.
• W2097202487 cites W1980923386 @default.
• W2097202487 cites W1981121993 @default.
• W2097202487 cites W1990540195 @default.
• W2097202487 cites W1992834800 @default.
• W2097202487 cites W1992969300 @default.
• W2097202487 cites W1994471498 @default.
• W2097202487 cites W1995780597 @default.
• W2097202487 cites W1997803551 @default.
• W2097202487 cites W1999231148 @default.
• W2097202487 cites W2007523516 @default.
• W2097202487 cites W2018342133 @default.
• W2097202487 cites W2031834089 @default.
• W2097202487 cites W2038852212 @default.
• W2097202487 cites W2042723121 @default.
• W2097202487 cites W2043952267 @default.
• W2097202487 cites W2054067609 @default.
• W2097202487 cites W2060888715 @default.
• W2097202487 cites W2061412350 @default.
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• W2097202487 cites W2069921929 @default.
• W2097202487 cites W2075443305 @default.
• W2097202487 cites W2077534740 @default.
• W2097202487 cites W2079110701 @default.
• W2097202487 cites W2079569240 @default.
• W2097202487 cites W2089264242 @default.
• W2097202487 cites W2089906970 @default.
• W2097202487 cites W2096782843 @default.
• W2097202487 cites W2097937496 @default.
• W2097202487 cites W2099537395 @default.
• W2097202487 cites W2100842198 @default.
• W2097202487 cites W2100896766 @default.
• W2097202487 cites W2107075639 @default.
• W2097202487 cites W2113362739 @default.
• W2097202487 cites W2114384627 @default.
• W2097202487 cites W2115285670 @default.
• W2097202487 cites W2115387528 @default.
• W2097202487 cites W2117456163 @default.
• W2097202487 cites W2117537948 @default.
• W2097202487 cites W2124719214 @default.
• W2097202487 cites W2131278205 @default.
• W2097202487 cites W2139706988 @default.
• W2097202487 cites W2141885768 @default.
• W2097202487 cites W2145053281 @default.
• W2097202487 cites W2148703802 @default.
• W2097202487 cites W2148706741 @default.
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• W2097202487 cites W2157775267 @default.
• W2097202487 cites W2158144486 @default.
• W2097202487 cites W2162394963 @default.
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• W2097202487 doi "https://doi.org/10.1186/2110-5820-2-17" @default.
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