FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097230686> ?p ?o ?g. }

• W2097230686 endingPage "40" @default.
• W2097230686 startingPage "28" @default.
• W2097230686 abstract "Aim: Immunosuppresion in oral squamous cell carcinoma (OSCC) is related to high degree of recurrence and believed to develop from premalignant lesion. Leukocytes especially T cell subsets are important in immune surveillance during malignant transformation. This study has been planned to observe changes in systemic immune response in premalignant and malignant oral lesions. Method: The proportions of Neutrophils, Monocytes, Lymphocytes, total T cells, T cell subsets including αβ/γδ T cells, Cytotoxic T cells, Helper T cells, Naive/ Effector/Memory T cells, Regulatory T cells and NK-T subpopulations were analysed in peripheral circulation of healthy donors (N= 49), Leukoplakia (N=20) and OSCC patients (N=100) by flowcytometry. Results: In comparison with healthy donors, decreased Lymphocytes, Naive Helper cells, NK T subpopulations and increased Effector cells were observed in Leukoplakia patients. Similarly, decreased Lymphocytes, NK T subpopulations and increased Neutrophils, Monocytes, Helper and Regulatory T cells were observed in OSCC patients as compared to healthy controls. Moreover, Lymphocytes were decreased and Regulatory T cells were increaed during the progression of Leukoplakia to OSCC. Further, in relation with clinicopathological parameters, Cytotoxic cells were found to be reduced with increasing histological grade. Also, Helper cells were found to be decreased in patients with tobacco and alcohol habit and also with increasing tumor size. Further, in univariate survival analysis, increased incidence of relapse was observed in patients with low γδ and NK T cells. In multivariate survival analysis, low γδ T cells emerged as poor prognosticator for disease free survival and high Regulatory T cells emerged as poor prognosticator for predicting overall survival. Conclusion: Altered systemic immune response was seen during malignant transformation and also found to be associated with patient’s survival. Thus, investigation of circulating Leukocyte and T cell subsets seems to be useful for predicting patient’s survival and to identify immunosuppressed patients who may be benefited with immunotherapy." @default.
• W2097230686 created "2016-06-24" @default.
• W2097230686 creator A5018560820 @default.
• W2097230686 creator A5023596636 @default.
• W2097230686 date "2014-01-23" @default.
• W2097230686 modified "2023-09-27" @default.
• W2097230686 title "Study of Immune Effector Cells in Leukoplakia and Oral Cancer" @default.
• W2097230686 cites W1430642159 @default.
• W2097230686 cites W1512225597 @default.
• W2097230686 cites W1541404499 @default.
• W2097230686 cites W1642873092 @default.
• W2097230686 cites W1678468169 @default.
• W2097230686 cites W1965303355 @default.
• W2097230686 cites W1975241511 @default.
• W2097230686 cites W1994666907 @default.
• W2097230686 cites W1994695445 @default.
• W2097230686 cites W1998292278 @default.
• W2097230686 cites W1998494751 @default.
• W2097230686 cites W2000843012 @default.
• W2097230686 cites W2007702854 @default.
• W2097230686 cites W2008381968 @default.
• W2097230686 cites W2014039953 @default.
• W2097230686 cites W2017381571 @default.
• W2097230686 cites W2025636084 @default.
• W2097230686 cites W2026483481 @default.
• W2097230686 cites W2041257236 @default.
• W2097230686 cites W2045325107 @default.
• W2097230686 cites W2055526655 @default.
• W2097230686 cites W2062274484 @default.
• W2097230686 cites W2063230624 @default.
• W2097230686 cites W2063882298 @default.
• W2097230686 cites W2065094930 @default.
• W2097230686 cites W2065363863 @default.
• W2097230686 cites W2070413881 @default.
• W2097230686 cites W2078056828 @default.
• W2097230686 cites W2091206905 @default.
• W2097230686 cites W2101847044 @default.
• W2097230686 cites W2110718030 @default.
• W2097230686 cites W2111238302 @default.
• W2097230686 cites W2117273788 @default.
• W2097230686 cites W2120490293 @default.
• W2097230686 cites W2122982027 @default.
• W2097230686 cites W2131660203 @default.
• W2097230686 cites W2136570726 @default.
• W2097230686 cites W2138163780 @default.
• W2097230686 cites W2139653196 @default.
• W2097230686 cites W2139806485 @default.
• W2097230686 cites W2142134244 @default.
• W2097230686 cites W2150678612 @default.
• W2097230686 cites W2150950354 @default.
• W2097230686 cites W2155804513 @default.
• W2097230686 cites W2163257247 @default.
• W2097230686 cites W2400678151 @default.
• W2097230686 cites W2526743575 @default.
• W2097230686 doi "https://doi.org/10.12691/jcrt-2-2-2" @default.
• W2097230686 hasPublicationYear "2014" @default.
• W2097230686 type Work @default.
• W2097230686 sameAs 2097230686 @default.
• W2097230686 citedByCount "0" @default.
• W2097230686 crossrefType "journal-article" @default.
• W2097230686 hasAuthorship W2097230686A5018560820 @default.
• W2097230686 hasAuthorship W2097230686A5023596636 @default.
• W2097230686 hasConcept C121608353 @default.
• W2097230686 hasConcept C126322002 @default.
• W2097230686 hasConcept C129374314 @default.
• W2097230686 hasConcept C154317977 @default.
• W2097230686 hasConcept C202751555 @default.
• W2097230686 hasConcept C203014093 @default.
• W2097230686 hasConcept C2776090121 @default.
• W2097230686 hasConcept C2777550702 @default.
• W2097230686 hasConcept C502942594 @default.
• W2097230686 hasConcept C51785407 @default.
• W2097230686 hasConcept C55493867 @default.
• W2097230686 hasConcept C71924100 @default.
• W2097230686 hasConcept C79484868 @default.
• W2097230686 hasConcept C86803240 @default.
• W2097230686 hasConcept C8891405 @default.
• W2097230686 hasConceptScore W2097230686C121608353 @default.
• W2097230686 hasConceptScore W2097230686C126322002 @default.
• W2097230686 hasConceptScore W2097230686C129374314 @default.
• W2097230686 hasConceptScore W2097230686C154317977 @default.
• W2097230686 hasConceptScore W2097230686C202751555 @default.
• W2097230686 hasConceptScore W2097230686C203014093 @default.
• W2097230686 hasConceptScore W2097230686C2776090121 @default.
• W2097230686 hasConceptScore W2097230686C2777550702 @default.
• W2097230686 hasConceptScore W2097230686C502942594 @default.
• W2097230686 hasConceptScore W2097230686C51785407 @default.
• W2097230686 hasConceptScore W2097230686C55493867 @default.
• W2097230686 hasConceptScore W2097230686C71924100 @default.
• W2097230686 hasConceptScore W2097230686C79484868 @default.
• W2097230686 hasConceptScore W2097230686C86803240 @default.
• W2097230686 hasConceptScore W2097230686C8891405 @default.
• W2097230686 hasIssue "2" @default.
• W2097230686 hasLocation W20972306861 @default.
• W2097230686 hasOpenAccess W2097230686 @default.
• W2097230686 hasPrimaryLocation W20972306861 @default.
• W2097230686 hasRelatedWork W1989747098 @default.
• W2097230686 hasRelatedWork W2029046266 @default.

• next