Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097232765> ?p ?o ?g. }
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- W2097232765 abstract "Amyloid-beta peptide (Abeta) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently demonstrated that Abeta induced oligodendrocyte (OLG) apoptosis, suggesting a role in white matter pathology in AD. Here, we explore the molecular mechanisms involved in Abeta-induced OLG death, examining the potential role of ceramide, a known apoptogenic mediator. Both Abeta and ceramide induced OLG death. In addition, Abeta activated neutral sphingomyelinase (nSMase), but not acidic sphingomyelinase, resulting in increased ceramide generation. Blocking ceramide degradation with N-oleoyl-ethanolamine exacerbated Abeta cytotoxicity; and addition of bacterial sphingomyelinase (mimicking cellular nSMase activity) induced OLG death. Furthermore, nSMase inhibition by 3-O-methyl-sphingomyelin or by gene knockdown using antisense oligonucleotides attenuated Abeta-induced OLG death. Glutathione (GSH) precursors inhibited Abeta activation of nSMase and prevented OLG death, whereas GSH depletors increased nSMase activity and Abeta-induced death. These results suggest that Abeta induces OLG death by activating the nSMase-ceramide cascade via an oxidative mechanism." @default.
- W2097232765 created "2016-06-24" @default.
- W2097232765 creator A5017557589 @default.
- W2097232765 creator A5023419869 @default.
- W2097232765 creator A5024057589 @default.
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- W2097232765 creator A5052845814 @default.
- W2097232765 creator A5062537585 @default.
- W2097232765 creator A5064265355 @default.
- W2097232765 date "2004-01-05" @default.
- W2097232765 modified "2023-10-14" @default.
- W2097232765 title "Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway" @default.
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- W2097232765 doi "https://doi.org/10.1083/jcb.200307017" @default.