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• W2097264549 abstract "Abstract —The rabbit inferior vena cava (IVC) is a large-capacitance vessel that displays typical contractile dose-response curves for caffeine and phenylephrine (PE). Using confocal microscopy on the endothelium-denuded IVC, we undertook experiments to correlate these whole-tissue contractile dose-response curves with changes in subcellular [Ca 2+ ] i signals in the in situ vascular smooth muscle cells (VSMCs). We observed that both caffeine and PE initially elicited Ca 2+ waves in individual VSMCs. The [Ca 2+ ] i in cells challenged with caffeine subsequently returned to baseline whereas the [Ca 2+ ] i in cells challenged with PE exhibited repetitive asynchronous Ca 2+ waves. These [Ca 2+ ] i oscillations were related to Ca 2+ release from the sarcoplasmic reticulum as they were inhibited by ryanodine and caffeine. The lack of synchronicity of the [Ca 2+ ] i oscillations between VSMCs can explain the observed tonic contraction at the whole-tissue level. The nature of these Ca 2+ waves was further characterized. For caffeine, the amplitude was all-or-none in nature, with individual cells differing in sensitivity, leading to their recruitment at different concentrations of the agonist. This concentration dependency of recruitment appears to form the basis for the concentration dependency of caffeine-induced contraction. Furthermore, the speed of the Ca 2+ waves correlated positively with the concentration of caffeine. In the case of PE, we observed the same characteristics with respect to wave speed, amplitude, and recruitment. Increasing concentrations of PE also enhance the frequency of the [Ca 2+ ] i oscillations. We therefore conclude that PE stimulates whole-tissue contractility through differential recruitment of VSMCs and enhancement of the frequency of asynchronous [Ca 2+ ] i oscillations once the cells are recruited. The full text of this article is available at http://www.circresaha.org." @default.
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• W2097264549 date "2000-03-03" @default.
• W2097264549 modified "2023-09-23" @default.
• W2097264549 title "Asynchronous Ca ²⁺ Waves in Intact Venous Smooth Muscle" @default.
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• W2097264549 doi "https://doi.org/10.1161/01.res.86.4.e72" @default.
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