FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097282105> ?p ?o ?g. }

• W2097282105 endingPage "2452" @default.
• W2097282105 startingPage "2447" @default.
• W2097282105 abstract "Compensatory hyperinsulinemia permitting insulin-resistant individuals to maintain normal glucose tolerance is associated with a left shift in the glucose-stimulated insulin secretion rate (GS-ISR) dose-response curve and decrease in the insulin metabolic clearance rate (I-MCR). To see whether these changes would reverse with improvement in insulin sensitivity, 14 nondiabetic insulin-resistant subjects received rosiglitazone for 12 weeks (4 mg daily for 4 weeks and then 8 mg daily for 8 weeks). Insulin-mediated glucose uptake was quantified by measuring the steady-state plasma glucose concentration during the insulin suppression test. GS-ISR and I-MCR were determined during a 240-min graded intravenous glucose infusion. I-MCR was also calculated during the insulin suppression test. After rosiglitazone treatment, insulin sensitivity improved with significant fall in steady-state plasma glucose (means ± SE from 13.5 ± 0.62 to 9.8 ± 1.02 mmol/l, P &lt; 0.001). In response, the integrated GS-ISR decreased by 21% (P &lt; 0.001), with a right shift in the dose-response curve. Calculated I-MCR increased by 34% (P = 0.008) during the insulin suppression test and by 21% (P = 0.03) during the graded glucose infusion. In conclusion, enhanced insulin sensitivity in rosiglitazone-treated nondiabetic insulin-resistant individuals was associated with a shift to the right in the GS-ISR dose-response curve and an increase in I-MCR." @default.
• W2097282105 created "2016-06-24" @default.
• W2097282105 creator A5005299025 @default.
• W2097282105 creator A5007064966 @default.
• W2097282105 creator A5023979858 @default.
• W2097282105 creator A5034657479 @default.
• W2097282105 creator A5045366155 @default.
• W2097282105 creator A5047102463 @default.
• W2097282105 creator A5067862582 @default.
• W2097282105 date "2005-08-01" @default.
• W2097282105 modified "2023-10-01" @default.
• W2097282105 title "Rosiglitazone Reduces Glucose-Stimulated Insulin Secretion Rate and Increases Insulin Clearance in Nondiabetic, Insulin-Resistant Individuals" @default.
• W2097282105 cites W1981212571 @default.
• W2097282105 cites W1999381960 @default.
• W2097282105 cites W2004551606 @default.
• W2097282105 cites W2030153054 @default.
• W2097282105 cites W2031885427 @default.
• W2097282105 cites W2036400933 @default.
• W2097282105 cites W2042692634 @default.
• W2097282105 cites W2051587973 @default.
• W2097282105 cites W2066802671 @default.
• W2097282105 cites W2079398589 @default.
• W2097282105 cites W2085281488 @default.
• W2097282105 cites W2085390992 @default.
• W2097282105 cites W2086423568 @default.
• W2097282105 cites W2090527653 @default.
• W2097282105 cites W2090895117 @default.
• W2097282105 cites W2097457805 @default.
• W2097282105 cites W2099789512 @default.
• W2097282105 cites W2105290412 @default.
• W2097282105 cites W2131796548 @default.
• W2097282105 cites W2132594773 @default.
• W2097282105 cites W2136427955 @default.
• W2097282105 cites W2138081409 @default.
• W2097282105 cites W2147098206 @default.
• W2097282105 cites W2162051951 @default.
• W2097282105 cites W2186184337 @default.
• W2097282105 cites W2319850088 @default.
• W2097282105 cites W2335922553 @default.
• W2097282105 cites W2335958328 @default.
• W2097282105 cites W2337133379 @default.
• W2097282105 cites W2415179536 @default.
• W2097282105 cites W2418805933 @default.
• W2097282105 cites W4233562854 @default.
• W2097282105 cites W4248487114 @default.
• W2097282105 cites W4249124461 @default.
• W2097282105 cites W4252910375 @default.
• W2097282105 cites W4253280909 @default.
• W2097282105 doi "https://doi.org/10.2337/diabetes.54.8.2447" @default.
• W2097282105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16046313" @default.
• W2097282105 hasPublicationYear "2005" @default.
• W2097282105 type Work @default.
• W2097282105 sameAs 2097282105 @default.
• W2097282105 citedByCount "41" @default.
• W2097282105 countsByYear W20972821052012 @default.
• W2097282105 countsByYear W20972821052013 @default.
• W2097282105 countsByYear W20972821052014 @default.
• W2097282105 countsByYear W20972821052015 @default.
• W2097282105 countsByYear W20972821052016 @default.
• W2097282105 countsByYear W20972821052017 @default.
• W2097282105 countsByYear W20972821052019 @default.
• W2097282105 countsByYear W20972821052021 @default.
• W2097282105 countsByYear W20972821052022 @default.
• W2097282105 crossrefType "journal-article" @default.
• W2097282105 hasAuthorship W2097282105A5005299025 @default.
• W2097282105 hasAuthorship W2097282105A5007064966 @default.
• W2097282105 hasAuthorship W2097282105A5023979858 @default.
• W2097282105 hasAuthorship W2097282105A5034657479 @default.
• W2097282105 hasAuthorship W2097282105A5045366155 @default.
• W2097282105 hasAuthorship W2097282105A5047102463 @default.
• W2097282105 hasAuthorship W2097282105A5067862582 @default.
• W2097282105 hasBestOaLocation W20972821051 @default.
• W2097282105 hasConcept C126322002 @default.
• W2097282105 hasConcept C134018914 @default.
• W2097282105 hasConcept C2777391703 @default.
• W2097282105 hasConcept C2777866211 @default.
• W2097282105 hasConcept C2779306644 @default.
• W2097282105 hasConcept C2780152017 @default.
• W2097282105 hasConcept C2780833929 @default.
• W2097282105 hasConcept C2780988686 @default.
• W2097282105 hasConcept C3017594758 @default.
• W2097282105 hasConcept C3020574416 @default.
• W2097282105 hasConcept C555293320 @default.
• W2097282105 hasConcept C71924100 @default.
• W2097282105 hasConcept C76318530 @default.
• W2097282105 hasConceptScore W2097282105C126322002 @default.
• W2097282105 hasConceptScore W2097282105C134018914 @default.
• W2097282105 hasConceptScore W2097282105C2777391703 @default.
• W2097282105 hasConceptScore W2097282105C2777866211 @default.
• W2097282105 hasConceptScore W2097282105C2779306644 @default.
• W2097282105 hasConceptScore W2097282105C2780152017 @default.
• W2097282105 hasConceptScore W2097282105C2780833929 @default.
• W2097282105 hasConceptScore W2097282105C2780988686 @default.
• W2097282105 hasConceptScore W2097282105C3017594758 @default.
• W2097282105 hasConceptScore W2097282105C3020574416 @default.
• W2097282105 hasConceptScore W2097282105C555293320 @default.
• W2097282105 hasConceptScore W2097282105C71924100 @default.
• W2097282105 hasConceptScore W2097282105C76318530 @default.

• next