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- W2097291433 abstract "The amount of human immunodeficiency virus (HIV) type 1 RNA and the presence of a codon 215 mutation indicative of zidovudine resistance were evaluated in cerebrospinal fluid (CSF) and plasma obtained from HIV-1-infected children. The level of HIV-1 RNA in CSF was highest in children with severe encephalopathy (n = 25; median, 430 copies/mL; range, 0-2.2 x 10(5) copies/mL) followed by the moderately encephalopathic (n = 7; median, 330; range, 0-1130) and nonencephalopathic groups (n = 9; median, 0; range, 0-566) (P = .007). There was no correlation between CSF and plasma HIV-1 RNA levels. Five of 7 children with the codon 215 mutation in CSF had a progression of encephalopathy, while all 8 children with wild type codon 215 had improved or stable disease during zidovudine treatment (P = .007). These findings suggest that increased viral replication and emergence of drug-resistant HIV-1 variants within the central nervous system may play a role in progression of HIV encephalopathy." @default.
- W2097291433 created "2016-06-24" @default.
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- W2097291433 date "1996-12-01" @default.
- W2097291433 modified "2023-09-27" @default.
- W2097291433 title "Evaluation of Human Immunodeficiency Virus (HIV) Type 1 RNA Levels in Cerebrospinal Fluid and Viral Resistance to Zidovudine in Children with HIV Encephalopathy" @default.
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- W2097291433 doi "https://doi.org/10.1093/infdis/174.6.1200" @default.
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