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• W2097301400 abstract "Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin. E-cadherin shedding disrupts epithelial barrier functions allowing H. pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori." @default.
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• W2097301400 date "2010-09-03" @default.
• W2097301400 modified "2023-10-12" @default.
• W2097301400 title "<i>Helicobacter pylori</i>HtrA is a new secreted virulence factor that cleaves E‐cadherin to disrupt intercellular adhesion" @default.
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• W2097301400 doi "https://doi.org/10.1038/embor.2010.114" @default.
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