FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097301466> ?p ?o ?g. }

• W2097301466 endingPage "622" @default.
• W2097301466 startingPage "613" @default.
• W2097301466 abstract "Understanding the events that are responsible for a disease is mandatory for setting up a therapeutic strategy. Although spinal muscular atrophy (SMA) is considered a rare neurodegenerative pathology, its impact in our society is really devastating as it strikes young people from birth onward, and it affects their families either emotionally or financially. Moreover, it requires intensive care for the children, and this diverts both parents and relatives from their occupations. Each neuron is very different from one another; therefore, in a neurodegenerative disease, the population of axons, synapses and cell bodies degenerate asynchronously, and subpopulations of neurons have different vulnerabilities. The knowledge of the sequence of events along the lengths of individual neurons is crucial to understand if each synapse degenerates before the corresponding axon, or if each axon degenerates before the corresponding cell body. Early degeneration of one neuronal compartment in disease often reflects molecular defects somewhere else. Up until now, SMA is considered mostly a lower motor neuron disease caused by the loss-of-function mutations in the SMN1 gene; here, we inspect other features that can be altered by this defect, such as the cross talk between muscle and motor neuron and the role of physical inactivity." @default.
• W2097301466 created "2016-06-24" @default.
• W2097301466 creator A5069765619 @default.
• W2097301466 creator A5084567168 @default.
• W2097301466 date "2013-06-28" @default.
• W2097301466 modified "2023-09-27" @default.
• W2097301466 title "Spinal Muscular Atrophy: New Findings for an Old Pathology" @default.
• W2097301466 cites W1546386885 @default.
• W2097301466 cites W1553805237 @default.
• W2097301466 cites W1965667084 @default.
• W2097301466 cites W1966656299 @default.
• W2097301466 cites W1973745643 @default.
• W2097301466 cites W1976243808 @default.
• W2097301466 cites W1979437987 @default.
• W2097301466 cites W1980477780 @default.
• W2097301466 cites W1982118908 @default.
• W2097301466 cites W1984680116 @default.
• W2097301466 cites W1984762946 @default.
• W2097301466 cites W1986164507 @default.
• W2097301466 cites W1987687980 @default.
• W2097301466 cites W1996412713 @default.
• W2097301466 cites W1996417439 @default.
• W2097301466 cites W2000261863 @default.
• W2097301466 cites W2000520189 @default.
• W2097301466 cites W2002112358 @default.
• W2097301466 cites W2005941403 @default.
• W2097301466 cites W2007222308 @default.
• W2097301466 cites W2008077083 @default.
• W2097301466 cites W2009309435 @default.
• W2097301466 cites W2011114330 @default.
• W2097301466 cites W2011623151 @default.
• W2097301466 cites W2012067705 @default.
• W2097301466 cites W2026841516 @default.
• W2097301466 cites W2027265085 @default.
• W2097301466 cites W2029865726 @default.
• W2097301466 cites W2034171100 @default.
• W2097301466 cites W2034784666 @default.
• W2097301466 cites W2036938071 @default.
• W2097301466 cites W2038285224 @default.
• W2097301466 cites W2040754808 @default.
• W2097301466 cites W2045117117 @default.
• W2097301466 cites W2046615897 @default.
• W2097301466 cites W2046790812 @default.
• W2097301466 cites W2047268435 @default.
• W2097301466 cites W2047345323 @default.
• W2097301466 cites W2054380003 @default.
• W2097301466 cites W2055219572 @default.
• W2097301466 cites W2058751007 @default.
• W2097301466 cites W2062890651 @default.
• W2097301466 cites W2062943152 @default.
• W2097301466 cites W2063711010 @default.
• W2097301466 cites W2068076855 @default.
• W2097301466 cites W2068087221 @default.
• W2097301466 cites W2071346782 @default.
• W2097301466 cites W2074697255 @default.
• W2097301466 cites W2081735313 @default.
• W2097301466 cites W2085465310 @default.
• W2097301466 cites W2087463887 @default.
• W2097301466 cites W2088094751 @default.
• W2097301466 cites W2089531592 @default.
• W2097301466 cites W2091658928 @default.
• W2097301466 cites W2096012750 @default.
• W2097301466 cites W2096650232 @default.
• W2097301466 cites W2098870365 @default.
• W2097301466 cites W2099377771 @default.
• W2097301466 cites W2104483488 @default.
• W2097301466 cites W2105283210 @default.
• W2097301466 cites W2111429264 @default.
• W2097301466 cites W2112430789 @default.
• W2097301466 cites W2119398996 @default.
• W2097301466 cites W2122329067 @default.
• W2097301466 cites W2122659262 @default.
• W2097301466 cites W2125191493 @default.
• W2097301466 cites W2126043264 @default.
• W2097301466 cites W2131512683 @default.
• W2097301466 cites W2137021233 @default.
• W2097301466 cites W2139899944 @default.
• W2097301466 cites W2140396456 @default.
• W2097301466 cites W2140853061 @default.
• W2097301466 cites W2142120640 @default.
• W2097301466 cites W2145042932 @default.
• W2097301466 cites W2149783843 @default.
• W2097301466 cites W2149863873 @default.
• W2097301466 cites W2157515039 @default.
• W2097301466 cites W2158751800 @default.
• W2097301466 cites W2160265494 @default.
• W2097301466 cites W2160696072 @default.
• W2097301466 cites W2163319886 @default.
• W2097301466 cites W2165235225 @default.
• W2097301466 cites W2165716325 @default.
• W2097301466 cites W2167132627 @default.
• W2097301466 cites W2170394786 @default.
• W2097301466 cites W2331108514 @default.
• W2097301466 doi "https://doi.org/10.1111/bpa.12071" @default.
• W2097301466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8029454" @default.
• W2097301466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23750936" @default.
• W2097301466 hasPublicationYear "2013" @default.
• W2097301466 type Work @default.

• next