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• W2097313599 abstract "Objective: To investigate the prevalence of and twin pair concordance for endometriosis.Design: A questionnaire survey incorporating validation.Setting: An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register.Patient(s): Twins were selected only on the basis of previous participation in twin research.Intervention(s): Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins.Main Outcome Measure(s): Reported endometriosis, validated where possible by pathology or surgical report.Result(s): Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMZ = .46 ± .09 and rDZ = .28 ± .13. When available medical and pathology reports were included, they changed to rMZ = .52 ± .08 and rDZ = .19 ± .16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences.Conclusion(s): These findings support the hypothesis that genes influence liability to endometriosis." @default.
• W2097313599 created "2016-06-24" @default.
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• W2097313599 date "1999-04-01" @default.
• W2097313599 modified "2023-10-16" @default.
• W2097313599 title "Genetic influences on endometriosis in an Australian twin sample" @default.
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• W2097313599 doi "https://doi.org/10.1016/s0015-0282(98)00540-8" @default.
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