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• W2097326394 abstract "Background: The coexistence of cutaneous T-cell lymphoma (CTCL) and a B-cell malignancy (BCM) is rare. Objective: Our aim was to assess the clinical and pathologic aspects of coexistent CTCL and BCM and to examine potential explanations for this association. Methods: We report six cases of concurrent CTCL and BCM in which B- and T-cell lineages were demonstrated by immunologic studies. The literature includes 13 additional cases. All 19 CTCL-BCM cases are reviewed. Results: CTCL either preceded or followed the BCM, which was a low-grade malignancy in most cases (1.6 of 19). Possible explanations for the association include a genetic predisposition, underlying viral infection, chemotherapy-induced carcinogenesis, stimulation of a B-cell clone by malignant helper T cells, and alterations in progenitor cells before determination of B- and T-cell lineage. Conclusion: An alteration in progenitor cells, with subsequent oncogenic activation of variable origin, might account for most cases of coexistent CTCL and BCM." @default.
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• W2097326394 date "1994-11-01" @default.
• W2097326394 modified "2023-09-26" @default.
• W2097326394 title "Coexistent cutaneous T-cell lymphoma and B-cell malignancy" @default.
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• W2097326394 doi "https://doi.org/10.1016/s0190-9622(94)70232-2" @default.
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