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• W2097330123 abstract "We previously demonstrated that typical American net acid-producing diets predict a low-grade metabolic acidosis of severity proportional to the diet net acid load as indexed by the steady-state renal net acid excretion rate (NAE). We now investigate whether a sodium (Na) chloride (Cl) containing diet likewise associates with a low-grade metabolic acidosis of severity proportional to the sodium chloride content of the diet as indexed by the steady-state Na and Cl excretion rates. In the steady-state preintervention periods of our previously reported studies comprising 77 healthy subjects, we averaged in each subject three to six values of blood hydrogen ion concentration ([H]b), plasma bicarbonate concentration ([HCO 3 − ]p), the partial pressure of carbon dioxide (Pco 2 ), the urinary excretion rates of Na, Cl, NAE, and renal function as measured by creatinine clearance (CrCl), and performed multivariate analyses. Dietary Cl strongly correlated positively with dietary Na ( P < 0.001) and was an independent negative predictor of [HCO 3 − ]p after adjustment for diet net acid load, Pco 2 and CrCl, and positive and negative predictors, respectively, of [H]b and [HCO 3 − ]p after adjustment for diet acid load and Pco 2 . These data provide the first evidence that, in healthy humans, the diet loads of NaCl and net acid independently predict systemic acid-base status, with increasing degrees of low-grade hyperchloremic metabolic acidosis as the loads increase. Assuming a causal relationship, over their respective ranges of variation, NaCl has ∼50–100% of the acidosis-producing effect of the diet net acid load." @default.
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• W2097330123 date "2007-08-01" @default.
• W2097330123 modified "2023-10-16" @default.
• W2097330123 title "Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet" @default.
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• W2097330123 doi "https://doi.org/10.1152/ajprenal.00048.2007" @default.
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