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• W2097331211 abstract "The specificity of many signal transduction pathways relies on the temporal coordination of different second messenger signals. Here we found a molecular mechanism which guarantees that conventional protein kinase C (PKC) isoforms are sequentially activated by calcium and diacylglycerol signals. Receptor stimuli that triggered repetitive calcium spikes induced a parallel repetitive translocation of GFP-tagged PKCgamma to the plasma membrane. While calcium acted rapidly, diacylglycerol binding to PKCgamma was initially prevented by a pseudosubstrate clamp, which kept the diacylglycerol-binding site inaccessible and delayed calcium- and diacylglycerol-mediated kinase activation. After termination of calcium signals, bound diacylglycerol prolonged kinase activity. The properties of this molecular decoding machine make PKCgamma responsive to persistent diacylglycerol increases combined with high- but not low-frequency calcium spikes." @default.
• W2097331211 created "2016-06-24" @default.
• W2097331211 creator A5021268165 @default.
• W2097331211 creator A5028702075 @default.
• W2097331211 date "1998-10-01" @default.
• W2097331211 modified "2023-10-17" @default.
• W2097331211 title "Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals" @default.
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• W2097331211 doi "https://doi.org/10.1016/s0092-8674(00)81763-8" @default.
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