FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097331346> ?p ?o ?g. }

• W2097331346 endingPage "423" @default.
• W2097331346 startingPage "414" @default.
• W2097331346 abstract "The incidence of venous thromboembolism (VTE) is more than 1 per thousand annually in the general population and increases further in cancer patients. The risk of VTE is higher in multiple myeloma (MM) patients who receive thalidomide or lenalidomide, especially in combination with dexamethasone or chemotherapy. Various VTE prophylaxis strategies, such as low-molecular-weight heparin (LMWH), warfarin or aspirin, have been investigated in small, uncontrolled clinical studies. This manuscript summarizes the available evidence and recommends a prophylaxis strategy according to a risk-assessment model. Individual risk factors for thrombosis associated with thalidomide/lenalidomide-based therapy include age, history of VTE, central venous catheter, comorbidities (infections, diabetes, cardiac disease), immobilization, surgery and inherited thrombophilia. Myeloma-related risk factors include diagnosis and hyperviscosity. VTE is very high in patients who receive high-dose dexamethasone, doxorubicin or multiagent chemotherapy in combination with thalidomide or lenalidomide, but not with bortezomib. The panel recommends aspirin for patients with < or = 1 risk factor for VTE. LMWH (equivalent to enoxaparin 40 mg per day) is recommended for those with two or more individual/myeloma-related risk factors. LMWH is also recommended for all patients receiving concurrent high-dose dexamethasone or doxorubicin. Full-dose warfarin targeting a therapeutic INR of 2-3 is an alternative to LMWH, although there are limited data in the literature with this strategy. In the absence of clear data from randomized studies as a foundation for recommendations, many of the following proposed strategies are the results of common sense or derive from the extrapolation of data from many studies not specifically designed to answer these questions. Further investigation is needed to define the best VTE prophylaxis." @default.
• W2097331346 created "2016-06-24" @default.
• W2097331346 creator A5000879635 @default.
• W2097331346 creator A5002061358 @default.
• W2097331346 creator A5002972322 @default.
• W2097331346 creator A5004466299 @default.
• W2097331346 creator A5004984519 @default.
• W2097331346 creator A5014845191 @default.
• W2097331346 creator A5016246851 @default.
• W2097331346 creator A5018139001 @default.
• W2097331346 creator A5020989412 @default.
• W2097331346 creator A5023276777 @default.
• W2097331346 creator A5025996929 @default.
• W2097331346 creator A5026109406 @default.
• W2097331346 creator A5026611811 @default.
• W2097331346 creator A5028662013 @default.
• W2097331346 creator A5031837957 @default.
• W2097331346 creator A5032464400 @default.
• W2097331346 creator A5033275967 @default.
• W2097331346 creator A5033573338 @default.
• W2097331346 creator A5034791164 @default.
• W2097331346 creator A5038235561 @default.
• W2097331346 creator A5043526996 @default.
• W2097331346 creator A5047187056 @default.
• W2097331346 creator A5051008993 @default.
• W2097331346 creator A5051786093 @default.
• W2097331346 creator A5055929208 @default.
• W2097331346 creator A5059967673 @default.
• W2097331346 creator A5066940168 @default.
• W2097331346 creator A5067110512 @default.
• W2097331346 creator A5067288478 @default.
• W2097331346 creator A5071926851 @default.
• W2097331346 creator A5073964632 @default.
• W2097331346 creator A5077846750 @default.
• W2097331346 creator A5080617550 @default.
• W2097331346 creator A5087775484 @default.
• W2097331346 date "2007-12-20" @default.
• W2097331346 modified "2023-10-14" @default.
• W2097331346 title "Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma" @default.
• W2097331346 cites W1516067462 @default.
• W2097331346 cites W1614927947 @default.
• W2097331346 cites W1867927052 @default.
• W2097331346 cites W1964643653 @default.
• W2097331346 cites W1966156828 @default.
• W2097331346 cites W1966623655 @default.
• W2097331346 cites W1970309861 @default.
• W2097331346 cites W1972996664 @default.
• W2097331346 cites W1975369179 @default.
• W2097331346 cites W1978808454 @default.
• W2097331346 cites W1984833612 @default.
• W2097331346 cites W1984949744 @default.
• W2097331346 cites W1985658104 @default.
• W2097331346 cites W1991820873 @default.
• W2097331346 cites W1992661527 @default.
• W2097331346 cites W2000080558 @default.
• W2097331346 cites W2000364384 @default.
• W2097331346 cites W2007086823 @default.
• W2097331346 cites W2013945874 @default.
• W2097331346 cites W2014826878 @default.
• W2097331346 cites W2018491765 @default.
• W2097331346 cites W2022932023 @default.
• W2097331346 cites W2023106232 @default.
• W2097331346 cites W2032411201 @default.
• W2097331346 cites W2033848804 @default.
• W2097331346 cites W2034372485 @default.
• W2097331346 cites W2039166615 @default.
• W2097331346 cites W2039511225 @default.
• W2097331346 cites W2040029744 @default.
• W2097331346 cites W2040324827 @default.
• W2097331346 cites W2043306284 @default.
• W2097331346 cites W2044889252 @default.
• W2097331346 cites W2051305187 @default.
• W2097331346 cites W2054324054 @default.
• W2097331346 cites W2063570477 @default.
• W2097331346 cites W2064439791 @default.
• W2097331346 cites W2065276135 @default.
• W2097331346 cites W2067086317 @default.
• W2097331346 cites W207103074 @default.
• W2097331346 cites W2071674957 @default.
• W2097331346 cites W2071779149 @default.
• W2097331346 cites W2073154438 @default.
• W2097331346 cites W2084605742 @default.
• W2097331346 cites W2095792323 @default.
• W2097331346 cites W2097087602 @default.
• W2097331346 cites W2100184560 @default.
• W2097331346 cites W2100997502 @default.
• W2097331346 cites W2103660186 @default.
• W2097331346 cites W2106226048 @default.
• W2097331346 cites W2106783894 @default.
• W2097331346 cites W2108503700 @default.
• W2097331346 cites W2110466835 @default.
• W2097331346 cites W2110891636 @default.
• W2097331346 cites W2113101033 @default.
• W2097331346 cites W2117172636 @default.
• W2097331346 cites W2118770994 @default.
• W2097331346 cites W2120161314 @default.
• W2097331346 cites W2123973590 @default.
• W2097331346 cites W2127206962 @default.

• next