FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097358179> ?p ?o ?g. }

• W2097358179 endingPage "3" @default.
• W2097358179 startingPage "2140" @default.
• W2097358179 abstract "Pancreatic adenocarcinoma is thought to arise from a noninvasive neoplastic precursor, the pancreatic intraductal lesion (PIL). Mutations of the K-ras gene are known to occur in PILs, but their high prevalence among PILs within the general population probably limit the use of K-ras as a marker of eventual clinical risk. In search of genetic constellations that might indicate the progression of some PILs toward an invasive phenotype, mutations at both the K-ras and p16 genes were sought within PILs of 10 pancreata resected for adenocarcinoma. K-ras mutations were present in most PILs and in nearly all PILs having nuclear atypia. In half of the patients, two or more unique K-ras mutations were identified among distinct PILs, which is evidence for the separate clonal evolution of multiple pancreatic neoplasms within individual patients. p16 alterations (one homozygous deletion and three point mutations) were found in 4 of the 10 carcinomas; these four pancreata harbored p16 alterations in three of nine PILs, of which one was a histologically early lesion. Two patients had p16 alterations in PILs matching those of the associated carcinomas. p16 mutations were not found in PILs of pancreata having wild-type p16 in the carcinoma, nor were they found in ducts having normal histology. It is suggested that alterations of the p16 gene affect a subset of PILs that contain mutations of the K-ras gene and that these mutations might identify high-risk precursors of the invasive malignancy." @default.
• W2097358179 created "2016-06-24" @default.
• W2097358179 creator A5001682484 @default.
• W2097358179 creator A5026775466 @default.
• W2097358179 creator A5036379332 @default.
• W2097358179 date "1997-06-01" @default.
• W2097358179 modified "2023-10-18" @default.
• W2097358179 title "p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma." @default.
• W2097358179 cites W149099508 @default.
• W2097358179 cites W1506859968 @default.
• W2097358179 cites W1557356779 @default.
• W2097358179 cites W156926268 @default.
• W2097358179 cites W1762220600 @default.
• W2097358179 cites W1998947396 @default.
• W2097358179 cites W2011334018 @default.
• W2097358179 cites W2036471644 @default.
• W2097358179 cites W2058162403 @default.
• W2097358179 cites W2058218248 @default.
• W2097358179 cites W2086109625 @default.
• W2097358179 cites W2100522747 @default.
• W2097358179 cites W2106212265 @default.
• W2097358179 cites W2125408410 @default.
• W2097358179 cites W2164034599 @default.
• W2097358179 cites W2207620686 @default.
• W2097358179 cites W2285254054 @default.
• W2097358179 cites W2326957512 @default.
• W2097358179 cites W2394729693 @default.
• W2097358179 cites W2403010325 @default.
• W2097358179 cites W2412979081 @default.
• W2097358179 cites W2416513008 @default.
• W2097358179 cites W94706099 @default.
• W2097358179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9187111" @default.
• W2097358179 hasPublicationYear "1997" @default.
• W2097358179 type Work @default.
• W2097358179 sameAs 2097358179 @default.
• W2097358179 citedByCount "160" @default.
• W2097358179 countsByYear W20973581792012 @default.
• W2097358179 countsByYear W20973581792013 @default.
• W2097358179 countsByYear W20973581792014 @default.
• W2097358179 countsByYear W20973581792015 @default.
• W2097358179 countsByYear W20973581792016 @default.
• W2097358179 countsByYear W20973581792017 @default.
• W2097358179 countsByYear W20973581792018 @default.
• W2097358179 countsByYear W20973581792019 @default.
• W2097358179 countsByYear W20973581792020 @default.
• W2097358179 countsByYear W20973581792021 @default.
• W2097358179 countsByYear W20973581792022 @default.
• W2097358179 countsByYear W20973581792023 @default.
• W2097358179 crossrefType "journal-article" @default.
• W2097358179 hasAuthorship W2097358179A5001682484 @default.
• W2097358179 hasAuthorship W2097358179A5026775466 @default.
• W2097358179 hasAuthorship W2097358179A5036379332 @default.
• W2097358179 hasConcept C104317684 @default.
• W2097358179 hasConcept C121608353 @default.
• W2097358179 hasConcept C127716648 @default.
• W2097358179 hasConcept C134018914 @default.
• W2097358179 hasConcept C142724271 @default.
• W2097358179 hasConcept C176944494 @default.
• W2097358179 hasConcept C2776737053 @default.
• W2097358179 hasConcept C2778764654 @default.
• W2097358179 hasConcept C2779399171 @default.
• W2097358179 hasConcept C2781182431 @default.
• W2097358179 hasConcept C2781283455 @default.
• W2097358179 hasConcept C2908647359 @default.
• W2097358179 hasConcept C501734568 @default.
• W2097358179 hasConcept C502942594 @default.
• W2097358179 hasConcept C54355233 @default.
• W2097358179 hasConcept C555283112 @default.
• W2097358179 hasConcept C71924100 @default.
• W2097358179 hasConcept C86803240 @default.
• W2097358179 hasConcept C99454951 @default.
• W2097358179 hasConceptScore W2097358179C104317684 @default.
• W2097358179 hasConceptScore W2097358179C121608353 @default.
• W2097358179 hasConceptScore W2097358179C127716648 @default.
• W2097358179 hasConceptScore W2097358179C134018914 @default.
• W2097358179 hasConceptScore W2097358179C142724271 @default.
• W2097358179 hasConceptScore W2097358179C176944494 @default.
• W2097358179 hasConceptScore W2097358179C2776737053 @default.
• W2097358179 hasConceptScore W2097358179C2778764654 @default.
• W2097358179 hasConceptScore W2097358179C2779399171 @default.
• W2097358179 hasConceptScore W2097358179C2781182431 @default.
• W2097358179 hasConceptScore W2097358179C2781283455 @default.
• W2097358179 hasConceptScore W2097358179C2908647359 @default.
• W2097358179 hasConceptScore W2097358179C501734568 @default.
• W2097358179 hasConceptScore W2097358179C502942594 @default.
• W2097358179 hasConceptScore W2097358179C54355233 @default.
• W2097358179 hasConceptScore W2097358179C555283112 @default.
• W2097358179 hasConceptScore W2097358179C71924100 @default.
• W2097358179 hasConceptScore W2097358179C86803240 @default.
• W2097358179 hasConceptScore W2097358179C99454951 @default.
• W2097358179 hasIssue "11" @default.
• W2097358179 hasLocation W20973581791 @default.
• W2097358179 hasOpenAccess W2097358179 @default.
• W2097358179 hasPrimaryLocation W20973581791 @default.
• W2097358179 hasRelatedWork W1946787458 @default.
• W2097358179 hasRelatedWork W1993884661 @default.
• W2097358179 hasRelatedWork W2002595078 @default.
• W2097358179 hasRelatedWork W2025824297 @default.

• next