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- W2097373005 abstract "The efficacy of a regional route for antibiotic prophylaxis in elective foot surgery was investigated in 20 patients and compared with the standard systemic intravenous method in 47 patients using two third-generation cephalosporins (ceftazidime and ceftriaxone). Each antibiotic (2 g) was given intravenously as the standard systemic prophylaxis at different intervals (10 min, 20 min, 2 h and 4 h) before tourniquet inflation. The same dose of each antibiotic was injected intravenously distal to the tourniquet after inflation. Samples of fat, skin, muscle and bone were collected from the foot and tissue levels of antibiotics were determined using a microbiological method. Peak tissue levels of the systemic antibiotics were administered 20 min before tourniquet inflation. For all tissue samples the antibiotic levels were significantly higher when the antibiotics were given regionally (P<0.001). The results of this study suggest that regional administration could be a useful route for prophylaxis during elective foot surgery." @default.
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- W2097373005 date "1995-09-01" @default.
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- W2097373005 title "Regional intravenous versus systemic intravenous prophylactic administration of third-generation cephalosporins (ceftazidime and ceftriaxone) in elective foot surgery" @default.
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- W2097373005 doi "https://doi.org/10.1016/0958-2592(95)90005-5" @default.
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