FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097373411> ?p ?o ?g. }

• W2097373411 endingPage "1974" @default.
• W2097373411 startingPage "1965" @default.
• W2097373411 abstract "Heat shock proteins (HSPs) like glycoprotein (gp)96 (glucose-regulated protein 94 [grp94]) are able to induce specific cytotoxic T lymphocyte (CTL) responses against cells from which they originate. Here, we demonstrate that for CTL activation by gp96-chaperoned peptides, specific receptor-mediated uptake of gp96 by antigen-presenting cells (APCs) is required. Moreover, we show that in both humans and mice, only professional APCs like dendritic cells (DCs), macrophages, and B cells, but not T cells, are able to bind gp96. The binding is saturable and can be inhibited using unlabeled gp96 molecules. Receptor binding by APCs leads to a rapid internalization of gp96, which colocalizes with endocytosed major histocompatibility complex (MHC) class I and class II molecules in endosomal compartments. Incubation of gp96 molecules isolated from cells expressing an adenovirus type 5 E1B epitope with the DC line D1 results in the activation of E1B-specific CTLs. This CTL activation can be specifically inhibited by the addition of irrelevant gp96 molecules not associated with E1B peptides. Our results demonstrate that only receptor-mediated endocytosis of gp96 molecules leads to MHC class I–restricted re-presentation of gp96-associated peptides and CTL activation; non–receptor-mediated, nonspecific endocytosis is not able to do so. Thus, we provide evidence on the mechanisms by which gp96 is participating in the cross-presentation of antigens from cellular origin." @default.
• W2097373411 created "2016-06-24" @default.
• W2097373411 creator A5007309983 @default.
• W2097373411 creator A5014729402 @default.
• W2097373411 creator A5046443771 @default.
• W2097373411 creator A5049437946 @default.
• W2097373411 creator A5057013667 @default.
• W2097373411 creator A5060457244 @default.
• W2097373411 creator A5067589440 @default.
• W2097373411 creator A5073708381 @default.
• W2097373411 creator A5084915056 @default.
• W2097373411 creator A5088597940 @default.
• W2097373411 creator A5090153362 @default.
• W2097373411 date "1999-06-06" @default.
• W2097373411 modified "2023-10-16" @default.
• W2097373411 title "Cross-Presentation of Glycoprotein 96–Associated Antigens on Major Histocompatibility Complex Class I Molecules Requires Receptor-Mediated Endocytosis" @default.
• W2097373411 cites W1509443850 @default.
• W2097373411 cites W1525792717 @default.
• W2097373411 cites W1547134586 @default.
• W2097373411 cites W1561591381 @default.
• W2097373411 cites W1574881121 @default.
• W2097373411 cites W1585393472 @default.
• W2097373411 cites W1614185919 @default.
• W2097373411 cites W1878232783 @default.
• W2097373411 cites W1944430208 @default.
• W2097373411 cites W1965438233 @default.
• W2097373411 cites W1966656613 @default.
• W2097373411 cites W1973401187 @default.
• W2097373411 cites W1977007393 @default.
• W2097373411 cites W1977298268 @default.
• W2097373411 cites W1984053151 @default.
• W2097373411 cites W1985481838 @default.
• W2097373411 cites W1986267292 @default.
• W2097373411 cites W1989709588 @default.
• W2097373411 cites W1989808086 @default.
• W2097373411 cites W1993234699 @default.
• W2097373411 cites W1997740378 @default.
• W2097373411 cites W2003656264 @default.
• W2097373411 cites W2017816736 @default.
• W2097373411 cites W2030898714 @default.
• W2097373411 cites W2041020348 @default.
• W2097373411 cites W2047003662 @default.
• W2097373411 cites W2053849689 @default.
• W2097373411 cites W2054023969 @default.
• W2097373411 cites W2059483129 @default.
• W2097373411 cites W2062569980 @default.
• W2097373411 cites W2066141983 @default.
• W2097373411 cites W2068692565 @default.
• W2097373411 cites W2075481963 @default.
• W2097373411 cites W2079794444 @default.
• W2097373411 cites W2080879611 @default.
• W2097373411 cites W2081430578 @default.
• W2097373411 cites W2083155294 @default.
• W2097373411 cites W2088982422 @default.
• W2097373411 cites W2090168014 @default.
• W2097373411 cites W2093143038 @default.
• W2097373411 cites W2106826370 @default.
• W2097373411 cites W2107491761 @default.
• W2097373411 cites W2108385981 @default.
• W2097373411 cites W2111695773 @default.
• W2097373411 cites W2112643590 @default.
• W2097373411 cites W2117312916 @default.
• W2097373411 cites W2123461995 @default.
• W2097373411 cites W2126678018 @default.
• W2097373411 cites W2130851972 @default.
• W2097373411 cites W2138294165 @default.
• W2097373411 cites W2143161597 @default.
• W2097373411 cites W2147077080 @default.
• W2097373411 cites W2147202630 @default.
• W2097373411 cites W2153004634 @default.
• W2097373411 cites W2166676682 @default.
• W2097373411 cites W2168400876 @default.
• W2097373411 cites W2170707246 @default.
• W2097373411 cites W2177327503 @default.
• W2097373411 cites W4313331292 @default.
• W2097373411 cites W4313331874 @default.
• W2097373411 doi "https://doi.org/10.1084/jem.191.11.1965" @default.
• W2097373411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2213530" @default.
• W2097373411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10839811" @default.
• W2097373411 hasPublicationYear "1999" @default.
• W2097373411 type Work @default.
• W2097373411 sameAs 2097373411 @default.
• W2097373411 citedByCount "338" @default.
• W2097373411 countsByYear W20973734112012 @default.
• W2097373411 countsByYear W20973734112013 @default.
• W2097373411 countsByYear W20973734112014 @default.
• W2097373411 countsByYear W20973734112015 @default.
• W2097373411 countsByYear W20973734112016 @default.
• W2097373411 countsByYear W20973734112017 @default.
• W2097373411 countsByYear W20973734112018 @default.
• W2097373411 countsByYear W20973734112019 @default.
• W2097373411 countsByYear W20973734112020 @default.
• W2097373411 countsByYear W20973734112021 @default.
• W2097373411 countsByYear W20973734112022 @default.
• W2097373411 countsByYear W20973734112023 @default.
• W2097373411 crossrefType "journal-article" @default.
• W2097373411 hasAuthorship W2097373411A5007309983 @default.
• W2097373411 hasAuthorship W2097373411A5014729402 @default.

• next