FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097378210> ?p ?o ?g. }

• W2097378210 endingPage "4042" @default.
• W2097378210 startingPage "4033" @default.
• W2097378210 abstract "Measles virus (MV), one of the most contagious viruses infecting humans, causes a systemic infection leading to fever, immune suppression, and a characteristic maculopapular rash. However, the specific mechanism or mechanisms responsible for the spread of MV into the respiratory epithelium in the late stages of the disease are unknown. Here we show the crucial role of PVRL4 in mediating the spread of MV from immune to epithelial cells by generating a PVRL4 blind recombinant wild-type MV and developing a novel in vitro coculture model of B cells with primary differentiated normal human bronchial epithelial cells. We utilized the macaque model of measles to analyze virus distribution in the respiratory tract prior to and at the peak of MV replication. Expression of PVRL4 was widespread in both the lower and upper respiratory tract (URT) of macaques, indicating MV transmission can be facilitated by more than only epithelial cells of the trachea. Analysis of tissues collected at early time points after experimental MV infection demonstrated the presence of MV-infected lymphoid and myeloid cells contacting respiratory tract epithelium in the absence of infected epithelial cells, suggesting that these immune cells seed the infection in vivo. Thereafter, lateral cell-to-cell spread of MV led to the formation of large foci of infected cells in the trachea and high levels of MV infection in the URT, particularly in the nasal cavity. These novel findings have important implications for our understanding of the high transmissibility of measles." @default.
• W2097378210 created "2016-06-24" @default.
• W2097378210 creator A5012442242 @default.
• W2097378210 creator A5012707353 @default.
• W2097378210 creator A5018562729 @default.
• W2097378210 creator A5021758736 @default.
• W2097378210 creator A5031207622 @default.
• W2097378210 creator A5037052996 @default.
• W2097378210 creator A5046489276 @default.
• W2097378210 creator A5047359982 @default.
• W2097378210 creator A5048652049 @default.
• W2097378210 creator A5065907032 @default.
• W2097378210 creator A5074409519 @default.
• W2097378210 date "2013-04-01" @default.
• W2097378210 modified "2023-10-18" @default.
• W2097378210 title "Measles Virus Infection of Epithelial Cells in the Macaque Upper Respiratory Tract Is Mediated by Subepithelial Immune Cells" @default.
• W2097378210 cites W1781043444 @default.
• W2097378210 cites W1968239579 @default.
• W2097378210 cites W1972194914 @default.
• W2097378210 cites W1978452294 @default.
• W2097378210 cites W1979936062 @default.
• W2097378210 cites W1989186078 @default.
• W2097378210 cites W2002828471 @default.
• W2097378210 cites W2039635444 @default.
• W2097378210 cites W2053449086 @default.
• W2097378210 cites W2054959451 @default.
• W2097378210 cites W2055735404 @default.
• W2097378210 cites W2065178191 @default.
• W2097378210 cites W2067847775 @default.
• W2097378210 cites W2081569298 @default.
• W2097378210 cites W2096950785 @default.
• W2097378210 cites W2099480075 @default.
• W2097378210 cites W2102769295 @default.
• W2097378210 cites W2116345938 @default.
• W2097378210 cites W2120113718 @default.
• W2097378210 cites W2128183313 @default.
• W2097378210 cites W2137679428 @default.
• W2097378210 cites W2150380586 @default.
• W2097378210 cites W2166812293 @default.
• W2097378210 doi "https://doi.org/10.1128/jvi.03258-12" @default.
• W2097378210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3624209" @default.
• W2097378210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23365435" @default.
• W2097378210 hasPublicationYear "2013" @default.
• W2097378210 type Work @default.
• W2097378210 sameAs 2097378210 @default.
• W2097378210 citedByCount "54" @default.
• W2097378210 countsByYear W20973782102013 @default.
• W2097378210 countsByYear W20973782102014 @default.
• W2097378210 countsByYear W20973782102015 @default.
• W2097378210 countsByYear W20973782102016 @default.
• W2097378210 countsByYear W20973782102017 @default.
• W2097378210 countsByYear W20973782102018 @default.
• W2097378210 countsByYear W20973782102019 @default.
• W2097378210 countsByYear W20973782102020 @default.
• W2097378210 countsByYear W20973782102021 @default.
• W2097378210 countsByYear W20973782102022 @default.
• W2097378210 countsByYear W20973782102023 @default.
• W2097378210 crossrefType "journal-article" @default.
• W2097378210 hasAuthorship W2097378210A5012442242 @default.
• W2097378210 hasAuthorship W2097378210A5012707353 @default.
• W2097378210 hasAuthorship W2097378210A5018562729 @default.
• W2097378210 hasAuthorship W2097378210A5021758736 @default.
• W2097378210 hasAuthorship W2097378210A5031207622 @default.
• W2097378210 hasAuthorship W2097378210A5037052996 @default.
• W2097378210 hasAuthorship W2097378210A5046489276 @default.
• W2097378210 hasAuthorship W2097378210A5047359982 @default.
• W2097378210 hasAuthorship W2097378210A5048652049 @default.
• W2097378210 hasAuthorship W2097378210A5065907032 @default.
• W2097378210 hasAuthorship W2097378210A5074409519 @default.
• W2097378210 hasBestOaLocation W20973782101 @default.
• W2097378210 hasConcept C105702510 @default.
• W2097378210 hasConcept C140704245 @default.
• W2097378210 hasConcept C159047783 @default.
• W2097378210 hasConcept C203014093 @default.
• W2097378210 hasConcept C22070199 @default.
• W2097378210 hasConcept C2522874641 @default.
• W2097378210 hasConcept C2776096392 @default.
• W2097378210 hasConcept C2776438120 @default.
• W2097378210 hasConcept C2778199166 @default.
• W2097378210 hasConcept C2779175743 @default.
• W2097378210 hasConcept C2779644171 @default.
• W2097378210 hasConcept C529295009 @default.
• W2097378210 hasConcept C534529494 @default.
• W2097378210 hasConcept C54355233 @default.
• W2097378210 hasConcept C86803240 @default.
• W2097378210 hasConcept C87568996 @default.
• W2097378210 hasConcept C8891405 @default.
• W2097378210 hasConceptScore W2097378210C105702510 @default.
• W2097378210 hasConceptScore W2097378210C140704245 @default.
• W2097378210 hasConceptScore W2097378210C159047783 @default.
• W2097378210 hasConceptScore W2097378210C203014093 @default.
• W2097378210 hasConceptScore W2097378210C22070199 @default.
• W2097378210 hasConceptScore W2097378210C2522874641 @default.
• W2097378210 hasConceptScore W2097378210C2776096392 @default.
• W2097378210 hasConceptScore W2097378210C2776438120 @default.
• W2097378210 hasConceptScore W2097378210C2778199166 @default.
• W2097378210 hasConceptScore W2097378210C2779175743 @default.
• W2097378210 hasConceptScore W2097378210C2779644171 @default.

• next