Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097381572> ?p ?o ?g. }
- W2097381572 endingPage "513" @default.
- W2097381572 startingPage "499" @default.
- W2097381572 abstract "Integrins are cell adhesion receptors that sense the extracellular matrix (ECM) environment. One of their functions is to regulate cell fate decisions, although the question of how integrins initiate intracellular signaling is not fully resolved. In this paper, we examine the role of talin, an adapter protein at cell–matrix attachment sites, in outside-in signaling. We used lentiviral small hairpin ribonucleic acid to deplete talin in mammary epithelial cells. These cells still attached to the ECM in an integrin-dependent manner and spread. They had a normal actin cytoskeleton, but vinculin, paxillin, focal adhesion kinase (FAK), and integrin-linked kinase were not recruited to adhesion sites. Talin-deficient cells showed proliferation defects, and reexpressing a tail portion of the talin rod, but not its head domain, restored integrin-mediated FAK phosphorylation, suppressed p21 expression, and rescued cell cycle. Thus, talin recruits and activates focal adhesion proteins required for proliferation via the C terminus of its rod domain. Our study reveals a new function for talin, which is to link integrin adhesions with cell cycle progression." @default.
- W2097381572 created "2016-06-24" @default.
- W2097381572 creator A5011754045 @default.
- W2097381572 creator A5022223788 @default.
- W2097381572 creator A5050904026 @default.
- W2097381572 date "2011-10-31" @default.
- W2097381572 modified "2023-10-15" @default.
- W2097381572 title "The C terminus of talin links integrins to cell cycle progression" @default.
- W2097381572 cites W1968766632 @default.
- W2097381572 cites W1970069848 @default.
- W2097381572 cites W1970831201 @default.
- W2097381572 cites W1988664472 @default.
- W2097381572 cites W1990883677 @default.
- W2097381572 cites W1994992313 @default.
- W2097381572 cites W1998383874 @default.
- W2097381572 cites W2001587874 @default.
- W2097381572 cites W2002982362 @default.
- W2097381572 cites W2004142977 @default.
- W2097381572 cites W2007096555 @default.
- W2097381572 cites W2009702029 @default.
- W2097381572 cites W2014606667 @default.
- W2097381572 cites W2021053981 @default.
- W2097381572 cites W2036988959 @default.
- W2097381572 cites W2037419242 @default.
- W2097381572 cites W2040379229 @default.
- W2097381572 cites W2049718632 @default.
- W2097381572 cites W2050106278 @default.
- W2097381572 cites W2056104802 @default.
- W2097381572 cites W2058096164 @default.
- W2097381572 cites W2059407064 @default.
- W2097381572 cites W2063575573 @default.
- W2097381572 cites W2069820450 @default.
- W2097381572 cites W2073576611 @default.
- W2097381572 cites W2077590283 @default.
- W2097381572 cites W2091119718 @default.
- W2097381572 cites W2092447350 @default.
- W2097381572 cites W2095388743 @default.
- W2097381572 cites W2101519746 @default.
- W2097381572 cites W2108496308 @default.
- W2097381572 cites W2109027836 @default.
- W2097381572 cites W2109137926 @default.
- W2097381572 cites W2118758577 @default.
- W2097381572 cites W2119824668 @default.
- W2097381572 cites W2120440477 @default.
- W2097381572 cites W2120902505 @default.
- W2097381572 cites W2121220704 @default.
- W2097381572 cites W2121781131 @default.
- W2097381572 cites W2124903948 @default.
- W2097381572 cites W2128005026 @default.
- W2097381572 cites W2134873228 @default.
- W2097381572 cites W2138750896 @default.
- W2097381572 cites W2139142739 @default.
- W2097381572 cites W2139691749 @default.
- W2097381572 cites W2140427830 @default.
- W2097381572 cites W2146122766 @default.
- W2097381572 cites W2149500786 @default.
- W2097381572 cites W2151914619 @default.
- W2097381572 cites W2153575042 @default.
- W2097381572 cites W2157809114 @default.
- W2097381572 cites W2158850412 @default.
- W2097381572 cites W2162005182 @default.
- W2097381572 cites W2164330595 @default.
- W2097381572 cites W2165078795 @default.
- W2097381572 doi "https://doi.org/10.1083/jcb.201104128" @default.
- W2097381572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3206343" @default.
- W2097381572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22042621" @default.
- W2097381572 hasPublicationYear "2011" @default.
- W2097381572 type Work @default.
- W2097381572 sameAs 2097381572 @default.
- W2097381572 citedByCount "93" @default.
- W2097381572 countsByYear W20973815722012 @default.
- W2097381572 countsByYear W20973815722013 @default.
- W2097381572 countsByYear W20973815722014 @default.
- W2097381572 countsByYear W20973815722015 @default.
- W2097381572 countsByYear W20973815722016 @default.
- W2097381572 countsByYear W20973815722017 @default.
- W2097381572 countsByYear W20973815722018 @default.
- W2097381572 countsByYear W20973815722019 @default.
- W2097381572 countsByYear W20973815722020 @default.
- W2097381572 countsByYear W20973815722021 @default.
- W2097381572 countsByYear W20973815722022 @default.
- W2097381572 countsByYear W20973815722023 @default.
- W2097381572 crossrefType "journal-article" @default.
- W2097381572 hasAuthorship W2097381572A5011754045 @default.
- W2097381572 hasAuthorship W2097381572A5022223788 @default.
- W2097381572 hasAuthorship W2097381572A5050904026 @default.
- W2097381572 hasBestOaLocation W20973815721 @default.
- W2097381572 hasConcept C108391706 @default.
- W2097381572 hasConcept C116581196 @default.
- W2097381572 hasConcept C142669718 @default.
- W2097381572 hasConcept C1491633281 @default.
- W2097381572 hasConcept C151166631 @default.
- W2097381572 hasConcept C189165786 @default.
- W2097381572 hasConcept C195687474 @default.
- W2097381572 hasConcept C195794163 @default.
- W2097381572 hasConcept C2777979848 @default.
- W2097381572 hasConcept C2993400109 @default.
- W2097381572 hasConcept C55493867 @default.