FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097396554> ?p ?o ?g. }

• W2097396554 endingPage "382" @default.
• W2097396554 startingPage "375" @default.
• W2097396554 abstract "OBJECTIVE. Erythropoietin has been shown to be protective against hypoxic-ischemic and inflammatory injuries in cell culture, animal models of brain injury, and clinical trials of adult humans. The rationale for our study was that early administration of high-dose recombinant human erythropoietin may reduce perinatal brain injury (intraventricular hemorrhage and periventricular leukomalacia) in very preterm infants and improve neurodevelopmental outcome. We investigated whether administration of high-dose recombinant human erythropoietin to very preterm infants shortly after birth and subsequently during the first 2 days is safe in terms of short-term outcome. METHODS. This was a randomized, double-masked, single-center trial with a 2:1 allocation in favor of recombinant human erythropoietin. Preterm infants (gestational age: 24 to 31 weeks) were given recombinant human erythropoietin or NaCl 0.9% intravenously 3, 12 to 18, and 36 to 42 hours after birth. RESULTS. The percentage of infants who survived without brain injury or retinopathy was 53% in the recombinant human erythropoietin group and 60% in the placebo group. There were no relevant differences regarding short-term outcomes such as intraventricular hemorrhage, retinopathy, sepsis, necrotizing enterocolitis, and bronchopulmonary dysplasia. For 5 infants who were in the recombinant human erythropoietin group and had a gestational age of &lt;26 weeks, withdrawal of intensive care was decided (3 of 5 with severe bilateral intraventricular hemorrhage, 2 of 5 with pulmonary insufficiency); no infant of the control group died. Recombinant human erythropoietin treatment did not result in significant differences in blood pressure, cerebral oxygenation, hemoglobin, leukocyte, and platelet count. CONCLUSIONS. No significant adverse effects of early high-dose recombinant human erythropoietin treatment in very preterm infants were identified. These results enable us to embark on a large multicenter trial with the aim of determining whether early high-dose administration of recombinant human erythropoietin to very preterm infants improves neurodevelopmental outcome at 24 months' and 5 years' corrected age." @default.
• W2097396554 created "2016-06-24" @default.
• W2097396554 creator A5006442525 @default.
• W2097396554 creator A5010960859 @default.
• W2097396554 creator A5026405660 @default.
• W2097396554 creator A5035275541 @default.
• W2097396554 creator A5050426428 @default.
• W2097396554 creator A5050886920 @default.
• W2097396554 creator A5073005521 @default.
• W2097396554 date "2008-08-01" @default.
• W2097396554 modified "2023-10-13" @default.
• W2097396554 title "An Approach to Using Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants" @default.
• W2097396554 cites W1514245259 @default.
• W2097396554 cites W1537228808 @default.
• W2097396554 cites W1538983550 @default.
• W2097396554 cites W1964838271 @default.
• W2097396554 cites W1969951251 @default.
• W2097396554 cites W1974716477 @default.
• W2097396554 cites W1987025848 @default.
• W2097396554 cites W1995694400 @default.
• W2097396554 cites W1997266616 @default.
• W2097396554 cites W1997790375 @default.
• W2097396554 cites W1998004065 @default.
• W2097396554 cites W2005002385 @default.
• W2097396554 cites W2016693709 @default.
• W2097396554 cites W2017516586 @default.
• W2097396554 cites W2019104466 @default.
• W2097396554 cites W2028628328 @default.
• W2097396554 cites W2030346622 @default.
• W2097396554 cites W2032926075 @default.
• W2097396554 cites W2041129185 @default.
• W2097396554 cites W2047950837 @default.
• W2097396554 cites W2050133386 @default.
• W2097396554 cites W2054131864 @default.
• W2097396554 cites W2066582680 @default.
• W2097396554 cites W2075590617 @default.
• W2097396554 cites W2080684014 @default.
• W2097396554 cites W2082670458 @default.
• W2097396554 cites W2083176137 @default.
• W2097396554 cites W2083309686 @default.
• W2097396554 cites W2086995514 @default.
• W2097396554 cites W2087849753 @default.
• W2097396554 cites W2105984287 @default.
• W2097396554 cites W2111144499 @default.
• W2097396554 cites W2112468487 @default.
• W2097396554 cites W2115406568 @default.
• W2097396554 cites W2118218277 @default.
• W2097396554 cites W2118570666 @default.
• W2097396554 cites W2122965222 @default.
• W2097396554 cites W2136112229 @default.
• W2097396554 cites W2141134283 @default.
• W2097396554 cites W2142463112 @default.
• W2097396554 cites W2143058635 @default.
• W2097396554 cites W2143627246 @default.
• W2097396554 cites W2145460322 @default.
• W2097396554 cites W2147604739 @default.
• W2097396554 cites W2160720400 @default.
• W2097396554 cites W2161854192 @default.
• W2097396554 cites W2168946139 @default.
• W2097396554 cites W4233140054 @default.
• W2097396554 cites W4239339630 @default.
• W2097396554 cites W87943494 @default.
• W2097396554 doi "https://doi.org/10.1542/peds.2007-2591" @default.
• W2097396554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18676556" @default.
• W2097396554 hasPublicationYear "2008" @default.
• W2097396554 type Work @default.
• W2097396554 sameAs 2097396554 @default.
• W2097396554 citedByCount "145" @default.
• W2097396554 countsByYear W20973965542012 @default.
• W2097396554 countsByYear W20973965542013 @default.
• W2097396554 countsByYear W20973965542014 @default.
• W2097396554 countsByYear W20973965542015 @default.
• W2097396554 countsByYear W20973965542016 @default.
• W2097396554 countsByYear W20973965542017 @default.
• W2097396554 countsByYear W20973965542018 @default.
• W2097396554 countsByYear W20973965542019 @default.
• W2097396554 countsByYear W20973965542020 @default.
• W2097396554 countsByYear W20973965542021 @default.
• W2097396554 countsByYear W20973965542022 @default.
• W2097396554 countsByYear W20973965542023 @default.
• W2097396554 crossrefType "journal-article" @default.
• W2097396554 hasAuthorship W2097396554A5006442525 @default.
• W2097396554 hasAuthorship W2097396554A5010960859 @default.
• W2097396554 hasAuthorship W2097396554A5026405660 @default.
• W2097396554 hasAuthorship W2097396554A5035275541 @default.
• W2097396554 hasAuthorship W2097396554A5050426428 @default.
• W2097396554 hasAuthorship W2097396554A5050886920 @default.
• W2097396554 hasAuthorship W2097396554A5073005521 @default.
• W2097396554 hasConcept C104317684 @default.
• W2097396554 hasConcept C126322002 @default.
• W2097396554 hasConcept C142724271 @default.
• W2097396554 hasConcept C185592680 @default.
• W2097396554 hasConcept C187212893 @default.
• W2097396554 hasConcept C204787440 @default.
• W2097396554 hasConcept C27081682 @default.
• W2097396554 hasConcept C2778376644 @default.
• W2097396554 hasConcept C2778384902 @default.
• W2097396554 hasConcept C2778534260 @default.

• next