Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097397623> ?p ?o ?g. }
- W2097397623 endingPage "1822" @default.
- W2097397623 startingPage "1812" @default.
- W2097397623 abstract "In this study, we present data showing that Cdc42-dependent lumen formation by endothelial cells (ECs) in three-dimensional (3D) collagen matrices involves coordinated signaling by PKCϵ in conjunction with the Src-family kinases (SFKs) Src and Yes. Activated SFKs interact with Cdc42 in multiprotein signaling complexes that require PKCϵ during this process. Src and Yes are differentially expressed during EC lumen formation and siRNA suppression of either kinase, but not Fyn or Lyn, results in significant inhibition of EC lumen formation. Concurrent with Cdc42 activation, PKCϵ- and SFK-dependent signaling converge to activate p21-activated kinase (Pak)2 and Pak4 in steps that are also required for EC lumen formation. Pak2 and Pak4 further activate two Raf kinases, B-Raf and C-Raf, leading to ERK1 and ERK2 (ERK1/2) activation, which all seem to be necessary for EC lumen formation. This work reveals a multicomponent kinase signaling pathway downstream of integrin-matrix interactions and Cdc42 activation involving PKCϵ, Src, Yes, Pak2, Pak4, B-Raf, C-Raf and ERK1/2 to control EC lumen formation in 3D collagen matrices." @default.
- W2097397623 created "2016-06-24" @default.
- W2097397623 creator A5021646316 @default.
- W2097397623 creator A5027982226 @default.
- W2097397623 creator A5034714897 @default.
- W2097397623 creator A5052327161 @default.
- W2097397623 creator A5071867964 @default.
- W2097397623 creator A5071937760 @default.
- W2097397623 creator A5089796560 @default.
- W2097397623 creator A5091819408 @default.
- W2097397623 date "2009-06-01" @default.
- W2097397623 modified "2023-10-15" @default.
- W2097397623 title "Formation of endothelial lumens requires a coordinated PKCϵ-, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation" @default.
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- W2097397623 doi "https://doi.org/10.1242/jcs.045799" @default.