FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097413462> ?p ?o ?g. }

• W2097413462 endingPage "387" @default.
• W2097413462 startingPage "373" @default.
• W2097413462 abstract "A selection of 43 Candida albicans isolates, chosen to represent the four major strain clades of the species and also intraclade diversity, was screened for their virulence in the murine intravenous challenge model of C. albicans infection, for a range of properties measurable in vitro that might relate to virulence, and for the numbers of midrepeat sequences in genes of the ALS and HYR families. Heterozygosity at the mating type locus and low whole-cell acid phosphatase activity and growth rate at 40 degrees C were found to be significantly positively associated with the most virulent isolates. Acid phosphatase activity and growth in 2 M NaCl were statistically significant variables between clades by univariate analysis. Isolates in different clades also differed significantly in midrepeat sequence alleles of ALS2, ALS4, ALS6, ALS7, ALS9, HYR1, and HYR2. There was no association between the midrepeat alleles of any ALS or HYR gene and the virulence of isolates to mice. Genome-wide transcript profiles of 20 isolates (5 per clade) grown under two conditions showed considerable variation between individual isolates, but only a small number of genes showed statistically significant differential gene expression between clades. Analysis of the expression profiles by overall strain virulence revealed 18 open reading frames differing significantly between isolates of high, intermediate, and low virulence. Four of these genes encoded functions related to phosphate uptake and metabolism. This finding and the significant association between whole-cell acid phosphatase activity and virulence led us to disrupt PHO100, which encodes a predicted periplasmic acid phosphatase. The pho100Delta mutant was mildly but significantly attenuated in terms of survival curves in the mouse model. The study has extended the range of properties known to differ between C. albicans clades and suggests a possible but minor role of phosphate metabolism in the virulence of the species." @default.
• W2097413462 created "2016-06-24" @default.
• W2097413462 creator A5008227126 @default.
• W2097413462 creator A5019826825 @default.
• W2097413462 creator A5030174171 @default.
• W2097413462 creator A5046770278 @default.
• W2097413462 creator A5053225241 @default.
• W2097413462 creator A5059894350 @default.
• W2097413462 creator A5088189848 @default.
• W2097413462 date "2009-03-01" @default.
• W2097413462 modified "2023-10-13" @default.
• W2097413462 title "Property Differences among the Four Major <i>Candida albicans</i> Strain Clades" @default.
• W2097413462 cites W1538743461 @default.
• W2097413462 cites W1892030338 @default.
• W2097413462 cites W1917430189 @default.
• W2097413462 cites W1968413325 @default.
• W2097413462 cites W1981427275 @default.
• W2097413462 cites W1987086017 @default.
• W2097413462 cites W1992264858 @default.
• W2097413462 cites W1995935584 @default.
• W2097413462 cites W1996489389 @default.
• W2097413462 cites W1999950146 @default.
• W2097413462 cites W2004307762 @default.
• W2097413462 cites W2022337918 @default.
• W2097413462 cites W2022578647 @default.
• W2097413462 cites W2032990061 @default.
• W2097413462 cites W2040625615 @default.
• W2097413462 cites W2047067218 @default.
• W2097413462 cites W2047794656 @default.
• W2097413462 cites W2066144154 @default.
• W2097413462 cites W2070265193 @default.
• W2097413462 cites W2076332935 @default.
• W2097413462 cites W2076847153 @default.
• W2097413462 cites W2088755036 @default.
• W2097413462 cites W2094361925 @default.
• W2097413462 cites W2097438508 @default.
• W2097413462 cites W2098979038 @default.
• W2097413462 cites W2103682285 @default.
• W2097413462 cites W2106451562 @default.
• W2097413462 cites W2106519526 @default.
• W2097413462 cites W2108053853 @default.
• W2097413462 cites W2110874942 @default.
• W2097413462 cites W2116830493 @default.
• W2097413462 cites W2120127088 @default.
• W2097413462 cites W2120218258 @default.
• W2097413462 cites W2121437188 @default.
• W2097413462 cites W2124393272 @default.
• W2097413462 cites W2125717834 @default.
• W2097413462 cites W2125994797 @default.
• W2097413462 cites W2131508520 @default.
• W2097413462 cites W2133725114 @default.
• W2097413462 cites W2134693978 @default.
• W2097413462 cites W2137044047 @default.
• W2097413462 cites W2140935709 @default.
• W2097413462 cites W2141672932 @default.
• W2097413462 cites W2146396346 @default.
• W2097413462 cites W2146529826 @default.
• W2097413462 cites W2146925163 @default.
• W2097413462 cites W2150543962 @default.
• W2097413462 cites W2151757612 @default.
• W2097413462 cites W2153207137 @default.
• W2097413462 cites W2153252627 @default.
• W2097413462 cites W2154687435 @default.
• W2097413462 cites W2155911607 @default.
• W2097413462 cites W2156470173 @default.
• W2097413462 cites W2157795344 @default.
• W2097413462 cites W2163812071 @default.
• W2097413462 cites W2164116124 @default.
• W2097413462 cites W2166379323 @default.
• W2097413462 cites W2168420911 @default.
• W2097413462 cites W2168705804 @default.
• W2097413462 cites W2171548303 @default.
• W2097413462 cites W4232741726 @default.
• W2097413462 cites W4294107304 @default.
• W2097413462 doi "https://doi.org/10.1128/ec.00387-08" @default.
• W2097413462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2653250" @default.
• W2097413462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19151328" @default.
• W2097413462 hasPublicationYear "2009" @default.
• W2097413462 type Work @default.
• W2097413462 sameAs 2097413462 @default.
• W2097413462 citedByCount "132" @default.
• W2097413462 countsByYear W20974134622012 @default.
• W2097413462 countsByYear W20974134622013 @default.
• W2097413462 countsByYear W20974134622014 @default.
• W2097413462 countsByYear W20974134622015 @default.
• W2097413462 countsByYear W20974134622016 @default.
• W2097413462 countsByYear W20974134622017 @default.
• W2097413462 countsByYear W20974134622018 @default.
• W2097413462 countsByYear W20974134622019 @default.
• W2097413462 countsByYear W20974134622020 @default.
• W2097413462 countsByYear W20974134622021 @default.
• W2097413462 countsByYear W20974134622022 @default.
• W2097413462 countsByYear W20974134622023 @default.
• W2097413462 crossrefType "journal-article" @default.
• W2097413462 hasAuthorship W2097413462A5008227126 @default.
• W2097413462 hasAuthorship W2097413462A5019826825 @default.
• W2097413462 hasAuthorship W2097413462A5030174171 @default.
• W2097413462 hasAuthorship W2097413462A5046770278 @default.

• next