FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097431115> ?p ?o ?g. }

• W2097431115 endingPage "708" @default.
• W2097431115 startingPage "701" @default.
• W2097431115 abstract "An abundance of microvessels is the major phenotype of pyogenic granuloma, which has been considered a hormone-related lesion based on clinical observations. Although angiogenic factors and inflammatory cytokines have been implied to play roles in the pathogenesis of pyogenic granuloma, their links to female steroid hormones still remain to be elucidated. Since apoptosis is important in limiting inflammation, we also investigated whether steroid hormones could protect granuloma cells from apoptosis and, therefore, lead to overreactive inflammatory response.We employed immunoassays in a series of experiments, including human pyogenic granuloma in pregnancy, mouse air pouch granuloma and U937 (monoblastoid) cells in culture to clarify the relationship among vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and female steroid hormones in granuloma formation. The apoptotic rates were analyzed in vivo and in vitro by terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick end labeling (TUNEL) and flow cytometry, respectively.Both in human and animal studies, the immunoassays (enzyme-linked immunoabsorbent assay [ELISA] and immunohistochemistry) detected significantly more VEGF and bFGF and less TNF-alpha in hormones than the control group, while TUNEL assay revealed less apoptotic cells in groups with pregnancy levels of hormones. In vitro, progesterone enhanced the expression of VEGF in LPS-treated U937 cells. Both estrogen and progesterone inhibited the apoptosis of U937 cells triggered by exogenous TNF-aFemale steroid hormones may have dual effects on the pathogenesis of pyogenic granuloma in pregnancy. The hormones not only enhance the expression of angiogenic factors in inflamed tissue, but also decrease apoptosis of granuloma cells to extend angiogenic effect." @default.
• W2097431115 created "2016-06-24" @default.
• W2097431115 creator A5046438444 @default.
• W2097431115 creator A5060841200 @default.
• W2097431115 creator A5070994118 @default.
• W2097431115 date "2002-07-01" @default.
• W2097431115 modified "2023-10-12" @default.
• W2097431115 title "Pathogenetic Roles of Angiogenic Factors in Pyogenic Granulornas in Pregnancy Are Modulated by Female <i>Sex</i> Hormones" @default.
• W2097431115 cites W1851414862 @default.
• W2097431115 cites W1964350307 @default.
• W2097431115 cites W1967270772 @default.
• W2097431115 cites W1972068610 @default.
• W2097431115 cites W1976333492 @default.
• W2097431115 cites W1999509093 @default.
• W2097431115 cites W2020006325 @default.
• W2097431115 cites W2030575224 @default.
• W2097431115 cites W2040418705 @default.
• W2097431115 cites W2044097582 @default.
• W2097431115 cites W2052701260 @default.
• W2097431115 cites W2054649668 @default.
• W2097431115 cites W2058362889 @default.
• W2097431115 cites W2058587734 @default.
• W2097431115 cites W2072794518 @default.
• W2097431115 cites W2089774206 @default.
• W2097431115 cites W2091482658 @default.
• W2097431115 cites W2129705073 @default.
• W2097431115 cites W2135002243 @default.
• W2097431115 cites W2162094586 @default.
• W2097431115 cites W2311972351 @default.
• W2097431115 cites W2405994238 @default.
• W2097431115 cites W4241451354 @default.
• W2097431115 cites W4244075688 @default.
• W2097431115 doi "https://doi.org/10.1902/jop.2002.73.7.701" @default.
• W2097431115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29539023" @default.
• W2097431115 hasPublicationYear "2002" @default.
• W2097431115 type Work @default.
• W2097431115 sameAs 2097431115 @default.
• W2097431115 citedByCount "89" @default.
• W2097431115 countsByYear W20974311152012 @default.
• W2097431115 countsByYear W20974311152013 @default.
• W2097431115 countsByYear W20974311152014 @default.
• W2097431115 countsByYear W20974311152015 @default.
• W2097431115 countsByYear W20974311152016 @default.
• W2097431115 countsByYear W20974311152017 @default.
• W2097431115 countsByYear W20974311152018 @default.
• W2097431115 countsByYear W20974311152019 @default.
• W2097431115 countsByYear W20974311152020 @default.
• W2097431115 countsByYear W20974311152021 @default.
• W2097431115 countsByYear W20974311152022 @default.
• W2097431115 countsByYear W20974311152023 @default.
• W2097431115 crossrefType "journal-article" @default.
• W2097431115 hasAuthorship W2097431115A5046438444 @default.
• W2097431115 hasAuthorship W2097431115A5060841200 @default.
• W2097431115 hasAuthorship W2097431115A5070994118 @default.
• W2097431115 hasConcept C126322002 @default.
• W2097431115 hasConcept C134018914 @default.
• W2097431115 hasConcept C142724271 @default.
• W2097431115 hasConcept C167734588 @default.
• W2097431115 hasConcept C17991360 @default.
• W2097431115 hasConcept C196795494 @default.
• W2097431115 hasConcept C204232928 @default.
• W2097431115 hasConcept C2777025900 @default.
• W2097431115 hasConcept C2780881361 @default.
• W2097431115 hasConcept C2781156865 @default.
• W2097431115 hasConcept C71315377 @default.
• W2097431115 hasConcept C71924100 @default.
• W2097431115 hasConcept C86803240 @default.
• W2097431115 hasConceptScore W2097431115C126322002 @default.
• W2097431115 hasConceptScore W2097431115C134018914 @default.
• W2097431115 hasConceptScore W2097431115C142724271 @default.
• W2097431115 hasConceptScore W2097431115C167734588 @default.
• W2097431115 hasConceptScore W2097431115C17991360 @default.
• W2097431115 hasConceptScore W2097431115C196795494 @default.
• W2097431115 hasConceptScore W2097431115C204232928 @default.
• W2097431115 hasConceptScore W2097431115C2777025900 @default.
• W2097431115 hasConceptScore W2097431115C2780881361 @default.
• W2097431115 hasConceptScore W2097431115C2781156865 @default.
• W2097431115 hasConceptScore W2097431115C71315377 @default.
• W2097431115 hasConceptScore W2097431115C71924100 @default.
• W2097431115 hasConceptScore W2097431115C86803240 @default.
• W2097431115 hasIssue "7" @default.
• W2097431115 hasLocation W20974311151 @default.
• W2097431115 hasLocation W20974311152 @default.
• W2097431115 hasOpenAccess W2097431115 @default.
• W2097431115 hasPrimaryLocation W20974311151 @default.
• W2097431115 hasRelatedWork W1975564052 @default.
• W2097431115 hasRelatedWork W2033686189 @default.
• W2097431115 hasRelatedWork W2104016888 @default.
• W2097431115 hasRelatedWork W2564118750 @default.
• W2097431115 hasRelatedWork W2729825693 @default.
• W2097431115 hasRelatedWork W2965401105 @default.
• W2097431115 hasRelatedWork W3020058267 @default.
• W2097431115 hasRelatedWork W4245933005 @default.
• W2097431115 hasRelatedWork W4383739574 @default.
• W2097431115 hasRelatedWork W2979041191 @default.
• W2097431115 hasVolume "73" @default.
• W2097431115 isParatext "false" @default.
• W2097431115 isRetracted "false" @default.

• next