FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097431611> ?p ?o ?g. }

• W2097431611 endingPage "302" @default.
• W2097431611 startingPage "294" @default.
• W2097431611 abstract "Objective To investigate whether regulatory T cells (Treg) can control B cell function in rheumatoid arthritis (RA) and if not to explore the basis for this defect. Methods Suppression of B cell responses by Treg was analysed in vitro by flow cytometry and ELISA using peripheral blood mononuclear cells from 65 patients with RA and 41 sex-matched and aged-matched healthy volunteers. Blocking and agonistic antibodies were used to define the role of Fas-mediated apoptosis in B cell regulation. Results Treg failed to restrain B cell activation, proinflammatory cytokine and antibody production in the presence of responder T cells in RA patients. This lack of suppression was not only caused by impaired Treg function but was also due to B cell resistance to regulation. In healthy donors, control by Treg was associated with increased B cell death and relied upon Fas-mediated apoptosis. In contrast, RA B cells had reduced Fas expression compared with their healthy counterparts and were resistant to Fas-mediated apoptosis. Conclusions These studies demonstrate that Treg are unable to limit B cell responses in RA. This appears to be primarily due to B cell resistance to suppression, but Treg defects also contribute to this failure of regulation. Our data identify the Fas pathway as a novel target for Treg-mediated suppression of B cells and highlight a potential therapeutic approach to restore control of B cells by Treg in RA patients." @default.
• W2097431611 created "2016-06-24" @default.
• W2097431611 creator A5018837563 @default.
• W2097431611 creator A5026458675 @default.
• W2097431611 creator A5028593271 @default.
• W2097431611 creator A5050093551 @default.
• W2097431611 date "2013-11-18" @default.
• W2097431611 modified "2023-10-01" @default.
• W2097431611 title "B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis" @default.
• W2097431611 cites W1522740791 @default.
• W2097431611 cites W1547789044 @default.
• W2097431611 cites W1555634619 @default.
• W2097431611 cites W1567676800 @default.
• W2097431611 cites W1679015646 @default.
• W2097431611 cites W1967908665 @default.
• W2097431611 cites W1969374521 @default.
• W2097431611 cites W1970254108 @default.
• W2097431611 cites W1984716802 @default.
• W2097431611 cites W1990723041 @default.
• W2097431611 cites W1997631819 @default.
• W2097431611 cites W2003197794 @default.
• W2097431611 cites W2013515819 @default.
• W2097431611 cites W2016345107 @default.
• W2097431611 cites W2029047024 @default.
• W2097431611 cites W2036383793 @default.
• W2097431611 cites W2041746341 @default.
• W2097431611 cites W2045444612 @default.
• W2097431611 cites W2050481876 @default.
• W2097431611 cites W2056457826 @default.
• W2097431611 cites W2063966481 @default.
• W2097431611 cites W2071872861 @default.
• W2097431611 cites W2072853625 @default.
• W2097431611 cites W2079632471 @default.
• W2097431611 cites W2087976968 @default.
• W2097431611 cites W2091280415 @default.
• W2097431611 cites W2096869658 @default.
• W2097431611 cites W2101010293 @default.
• W2097431611 cites W2101740705 @default.
• W2097431611 cites W2103497996 @default.
• W2097431611 cites W2118268169 @default.
• W2097431611 cites W2118994799 @default.
• W2097431611 cites W2121877209 @default.
• W2097431611 cites W2123249923 @default.
• W2097431611 cites W2132440788 @default.
• W2097431611 cites W2133958296 @default.
• W2097431611 cites W2134940917 @default.
• W2097431611 cites W2137294107 @default.
• W2097431611 cites W2140791963 @default.
• W2097431611 cites W2142611445 @default.
• W2097431611 cites W2145047950 @default.
• W2097431611 cites W2145611701 @default.
• W2097431611 cites W2152807226 @default.
• W2097431611 cites W2158634512 @default.
• W2097431611 cites W2159346740 @default.
• W2097431611 cites W2161545566 @default.
• W2097431611 cites W2166488783 @default.
• W2097431611 cites W4235476424 @default.
• W2097431611 doi "https://doi.org/10.1136/annrheumdis-2013-204049" @default.
• W2097431611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24249811" @default.
• W2097431611 hasPublicationYear "2013" @default.
• W2097431611 type Work @default.
• W2097431611 sameAs 2097431611 @default.
• W2097431611 citedByCount "32" @default.
• W2097431611 countsByYear W20974316112014 @default.
• W2097431611 countsByYear W20974316112015 @default.
• W2097431611 countsByYear W20974316112016 @default.
• W2097431611 countsByYear W20974316112017 @default.
• W2097431611 countsByYear W20974316112018 @default.
• W2097431611 countsByYear W20974316112019 @default.
• W2097431611 countsByYear W20974316112020 @default.
• W2097431611 countsByYear W20974316112021 @default.
• W2097431611 countsByYear W20974316112022 @default.
• W2097431611 countsByYear W20974316112023 @default.
• W2097431611 crossrefType "journal-article" @default.
• W2097431611 hasAuthorship W2097431611A5018837563 @default.
• W2097431611 hasAuthorship W2097431611A5026458675 @default.
• W2097431611 hasAuthorship W2097431611A5028593271 @default.
• W2097431611 hasAuthorship W2097431611A5050093551 @default.
• W2097431611 hasBestOaLocation W20974316111 @default.
• W2097431611 hasConcept C137061746 @default.
• W2097431611 hasConcept C159654299 @default.
• W2097431611 hasConcept C164027704 @default.
• W2097431611 hasConcept C190283241 @default.
• W2097431611 hasConcept C202751555 @default.
• W2097431611 hasConcept C203014093 @default.
• W2097431611 hasConcept C2776090121 @default.
• W2097431611 hasConcept C2776914184 @default.
• W2097431611 hasConcept C2777575956 @default.
• W2097431611 hasConcept C2778296632 @default.
• W2097431611 hasConcept C2778453870 @default.
• W2097431611 hasConcept C2778690821 @default.
• W2097431611 hasConcept C2781438807 @default.
• W2097431611 hasConcept C502942594 @default.
• W2097431611 hasConcept C553184892 @default.
• W2097431611 hasConcept C55493867 @default.
• W2097431611 hasConcept C71924100 @default.
• W2097431611 hasConcept C79484868 @default.
• W2097431611 hasConcept C86803240 @default.

• next