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- W2097451675 abstract "Aminoglycosides are one of the most widely used and clinically important classes of antibiotics that target the ribosome. Hygromycin B is an atypical aminoglycoside antibiotic with unique structural and functional properties. Here we describe the structure of the intact Escherichia coli 70S ribosome in complex with hygromycin B. The antibiotic binds to the mRNA decoding center in the small (30S) ribosomal subunit of the 70S ribosome and induces a localized conformational change, in contrast to its effects observed in the structure of the isolated 30S ribosomal subunit in complex with the drug. The conformational change in the ribosome caused by hygromycin B binding differs from that induced by other aminoglycosides. Also, in contrast to other aminoglycosides, hygromycin B potently inhibits spontaneous reverse translocation of tRNAs and mRNA on the ribosome in vitro. These structural and biochemical results help to explain the unique mode of translation inhibition by hygromycin B." @default.
- W2097451675 created "2016-06-24" @default.
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- W2097451675 creator A5033210199 @default.
- W2097451675 creator A5054018140 @default.
- W2097451675 creator A5061385991 @default.
- W2097451675 date "2008-06-20" @default.
- W2097451675 modified "2023-10-07" @default.
- W2097451675 title "Structural basis for hygromycin B inhibition of protein biosynthesis" @default.
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- W2097451675 cites W1564221315 @default.
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- W2097451675 cites W1963597574 @default.
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- W2097451675 cites W1980231232 @default.
- W2097451675 cites W1980412333 @default.
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- W2097451675 cites W2007839470 @default.
- W2097451675 cites W2008200003 @default.
- W2097451675 cites W2008317513 @default.
- W2097451675 cites W2013083986 @default.
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- W2097451675 cites W2018280419 @default.
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- W2097451675 cites W2035144789 @default.
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- W2097451675 cites W2075970359 @default.
- W2097451675 cites W2076631011 @default.
- W2097451675 cites W2082475735 @default.
- W2097451675 cites W2084016545 @default.
- W2097451675 cites W2086402273 @default.
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- W2097451675 cites W2156428769 @default.
- W2097451675 cites W2163231470 @default.
- W2097451675 cites W2167144254 @default.
- W2097451675 cites W2167340225 @default.
- W2097451675 cites W2170243611 @default.
- W2097451675 cites W2170672488 @default.
- W2097451675 cites W2178893660 @default.
- W2097451675 cites W2313291284 @default.
- W2097451675 cites W2319216747 @default.
- W2097451675 cites W2404231370 @default.
- W2097451675 cites W2406401382 @default.
- W2097451675 cites W4239023878 @default.
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- W2097451675 doi "https://doi.org/10.1261/rna.1076908" @default.
- W2097451675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2491480" @default.
- W2097451675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18567815" @default.
- W2097451675 hasPublicationYear "2008" @default.
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