Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097455416> ?p ?o ?g. }
- W2097455416 endingPage "578" @default.
- W2097455416 startingPage "578" @default.
- W2097455416 abstract "Diffusion tensor magnetic resonance imaging (DT MRI) has the potential to provide in vivo information about tissue microstructure. In multiple sclerosis (MS), DT MRI has disclosed the presence of occult structural damage in the normal-appearing brain tissues.To investigate whether DT MRI is sensitive to longitudinal changes of brain damage that may occur beyond the resolution of T2-weighted images in patients with relapsing-remitting MS.Twenty-six untreated patients with relapsing-remitting MS were followed up for 18 months. Dual-echo, DT and postcontrast T1-weighted MRIs of the brain were obtained at baseline and then every 3 months. Mean diffusivity (D) histograms of normal-appearing gray (GM) and white matter were produced. Total T2-hyperintense and T1-hypointense lesion volumes; normalized whole brain tissue, GM, and white matter volumes; percentage brain volume change between the study entry and exit images; average lesion D; and fractional anisotropy were also calculated.During the study period, a significant decrease of normalized whole brain tissue, average lesion fractional anisotropy and normal-appearing GM D histogram peak height, and a significant increase of average normal-appearing GM D and T2-hyperintense lesion volumes were observed. Changes of normal-appearing GM diffusivity were independent of the concomitant changes of normalized whole brain tissue and GM volumes.The DT MRI findings show progressive microstructural changes in the normal-appearing GM of patients with untreated relapsing-remitting MS. Such changes do not reflect a concomitant development of brain atrophy and confirm the importance of GM pathology in MS." @default.
- W2097455416 created "2016-06-24" @default.
- W2097455416 creator A5000208695 @default.
- W2097455416 creator A5003010065 @default.
- W2097455416 creator A5005439850 @default.
- W2097455416 creator A5018024307 @default.
- W2097455416 creator A5030915973 @default.
- W2097455416 creator A5031754069 @default.
- W2097455416 creator A5059578809 @default.
- W2097455416 creator A5070147983 @default.
- W2097455416 creator A5072157109 @default.
- W2097455416 creator A5088301395 @default.
- W2097455416 date "2005-04-01" @default.
- W2097455416 modified "2023-10-17" @default.
- W2097455416 title "Progressive Gray Matter Damage in Patients With Relapsing-Remitting Multiple Sclerosis" @default.
- W2097455416 cites W1268092259 @default.
- W2097455416 cites W1482855280 @default.
- W2097455416 cites W1926586119 @default.
- W2097455416 cites W1953823942 @default.
- W2097455416 cites W1970044218 @default.
- W2097455416 cites W1971334524 @default.
- W2097455416 cites W1974366107 @default.
- W2097455416 cites W1981866033 @default.
- W2097455416 cites W1982391741 @default.
- W2097455416 cites W1992485268 @default.
- W2097455416 cites W1997024092 @default.
- W2097455416 cites W1997394308 @default.
- W2097455416 cites W1998299241 @default.
- W2097455416 cites W1999210265 @default.
- W2097455416 cites W2013091225 @default.
- W2097455416 cites W2015052590 @default.
- W2097455416 cites W2017381757 @default.
- W2097455416 cites W2028942474 @default.
- W2097455416 cites W2036150740 @default.
- W2097455416 cites W2047326314 @default.
- W2097455416 cites W2050468619 @default.
- W2097455416 cites W2052922204 @default.
- W2097455416 cites W2063631125 @default.
- W2097455416 cites W2063790730 @default.
- W2097455416 cites W2067962939 @default.
- W2097455416 cites W2073804933 @default.
- W2097455416 cites W2076774201 @default.
- W2097455416 cites W2082506742 @default.
- W2097455416 cites W2087577005 @default.
- W2097455416 cites W2087589796 @default.
- W2097455416 cites W2089793429 @default.
- W2097455416 cites W2090748566 @default.
- W2097455416 cites W2106677794 @default.
- W2097455416 cites W2110080262 @default.
- W2097455416 cites W2112078511 @default.
- W2097455416 cites W2112165124 @default.
- W2097455416 cites W2116832207 @default.
- W2097455416 cites W2117963842 @default.
- W2097455416 cites W2126572298 @default.
- W2097455416 cites W2126654365 @default.
- W2097455416 cites W2130355701 @default.
- W2097455416 cites W2136573752 @default.
- W2097455416 cites W2141185335 @default.
- W2097455416 cites W2141510919 @default.
- W2097455416 cites W2147133578 @default.
- W2097455416 cites W2154817143 @default.
- W2097455416 cites W2164721910 @default.
- W2097455416 cites W2316203136 @default.
- W2097455416 cites W2411791653 @default.
- W2097455416 cites W2417861748 @default.
- W2097455416 doi "https://doi.org/10.1001/archneur.62.4.578" @default.
- W2097455416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15824256" @default.
- W2097455416 hasPublicationYear "2005" @default.
- W2097455416 type Work @default.
- W2097455416 sameAs 2097455416 @default.
- W2097455416 citedByCount "93" @default.
- W2097455416 countsByYear W20974554162012 @default.
- W2097455416 countsByYear W20974554162013 @default.
- W2097455416 countsByYear W20974554162014 @default.
- W2097455416 countsByYear W20974554162015 @default.
- W2097455416 countsByYear W20974554162016 @default.
- W2097455416 countsByYear W20974554162017 @default.
- W2097455416 countsByYear W20974554162018 @default.
- W2097455416 countsByYear W20974554162019 @default.
- W2097455416 countsByYear W20974554162021 @default.
- W2097455416 countsByYear W20974554162022 @default.
- W2097455416 countsByYear W20974554162023 @default.
- W2097455416 crossrefType "journal-article" @default.
- W2097455416 hasAuthorship W2097455416A5000208695 @default.
- W2097455416 hasAuthorship W2097455416A5003010065 @default.
- W2097455416 hasAuthorship W2097455416A5005439850 @default.
- W2097455416 hasAuthorship W2097455416A5018024307 @default.
- W2097455416 hasAuthorship W2097455416A5030915973 @default.
- W2097455416 hasAuthorship W2097455416A5031754069 @default.
- W2097455416 hasAuthorship W2097455416A5059578809 @default.
- W2097455416 hasAuthorship W2097455416A5070147983 @default.
- W2097455416 hasAuthorship W2097455416A5072157109 @default.
- W2097455416 hasAuthorship W2097455416A5088301395 @default.
- W2097455416 hasBestOaLocation W20974554161 @default.
- W2097455416 hasConcept C118552586 @default.
- W2097455416 hasConcept C126838900 @default.
- W2097455416 hasConcept C142724271 @default.
- W2097455416 hasConcept C143409427 @default.