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- W2097473353 abstract "During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles." @default.
- W2097473353 created "2016-06-24" @default.
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- W2097473353 date "2007-06-18" @default.
- W2097473353 modified "2023-10-17" @default.
- W2097473353 title "Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development" @default.
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- W2097473353 doi "https://doi.org/10.1083/jcb.200610108" @default.
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