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- W2097474705 startingPage "3457" @default.
- W2097474705 abstract "Appropriate regulation of signal transduction pathways is essential for normal development and is often disrupted in disease. Therefore, many regulatory mechanisms and feedback loops have evolved to ensure appropriate signalling. One mechanism previously suggested to modulate a range of signal transduction pathways involves the internalisation and destruction of transmembrane receptors by the endocytic trafficking machinery. Strikingly, a recent report has suggested that the endocytic trafficking of the Drosophila JAK–STAT pathway receptor Domeless (Dome) does not act to downregulate pathway activity, but rather is necessary for in vivo signalling. Here, we examine this relationship to address the interaction of Drosophila JAK–STAT pathway signalling and endocytic trafficking. We show that Dome is trafficked through clathrin-mediated endocytosis and a directed RNAi screen identified several components of the endocytic machinery as negative regulators of pathway signalling. We demonstrate that Dome signals both from the plasma membrane and internalised vesicles and show, using knockdown experiments, that endocytic components negatively regulate JAK–STAT signalling in vivo. As such, disruption in endocytic trafficking represents a potent negative regulator of the disease relevant JAK–STAT signalling cascade." @default.
- W2097474705 created "2016-06-24" @default.
- W2097474705 creator A5004844482 @default.
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- W2097474705 creator A5062407171 @default.
- W2097474705 creator A5083841698 @default.
- W2097474705 creator A5086293669 @default.
- W2097474705 date "2010-10-15" @default.
- W2097474705 modified "2023-10-15" @default.
- W2097474705 title "Negative regulation of<i>Drosophila</i>JAK–STAT signalling by endocytic trafficking" @default.
- W2097474705 cites W1008499258 @default.
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- W2097474705 cites W1600880434 @default.
- W2097474705 cites W1966311581 @default.
- W2097474705 cites W1968729630 @default.
- W2097474705 cites W1968733649 @default.
- W2097474705 cites W1970061483 @default.
- W2097474705 cites W1975063481 @default.
- W2097474705 cites W1976028208 @default.
- W2097474705 cites W1980568348 @default.
- W2097474705 cites W1983396297 @default.
- W2097474705 cites W1988367343 @default.
- W2097474705 cites W1988719795 @default.
- W2097474705 cites W1991735821 @default.
- W2097474705 cites W1995432390 @default.
- W2097474705 cites W1996479930 @default.
- W2097474705 cites W1998148517 @default.
- W2097474705 cites W1999232604 @default.
- W2097474705 cites W2001393635 @default.
- W2097474705 cites W2005574904 @default.
- W2097474705 cites W2007215986 @default.
- W2097474705 cites W2007917670 @default.
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- W2097474705 cites W2008665417 @default.
- W2097474705 cites W2009843720 @default.
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- W2097474705 cites W2020531165 @default.
- W2097474705 cites W2025022118 @default.
- W2097474705 cites W2028088511 @default.
- W2097474705 cites W2030266533 @default.
- W2097474705 cites W2032490025 @default.
- W2097474705 cites W2038863154 @default.
- W2097474705 cites W2045241135 @default.
- W2097474705 cites W2046133662 @default.
- W2097474705 cites W2047531031 @default.
- W2097474705 cites W2054524606 @default.
- W2097474705 cites W2055786440 @default.
- W2097474705 cites W2059276027 @default.
- W2097474705 cites W2063206483 @default.
- W2097474705 cites W2063692341 @default.
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- W2097474705 cites W2072482079 @default.
- W2097474705 cites W2077904579 @default.
- W2097474705 cites W2085144734 @default.
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- W2097474705 cites W2119157263 @default.
- W2097474705 cites W2126967459 @default.
- W2097474705 cites W2128702749 @default.
- W2097474705 cites W2135424108 @default.
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- W2097474705 cites W2167806590 @default.
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- W2097474705 cites W2171797115 @default.
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- W2097474705 doi "https://doi.org/10.1242/jcs.066902" @default.
- W2097474705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2951467" @default.
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- W2097474705 hasPublicationYear "2010" @default.
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