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• W2097476078 endingPage "36047" @default.
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• W2097476078 abstract "Of the four known globin genes that exist in the fresh-water crustacean <i>Daphnia magna</i>, several are individually induced by hypoxia, lending pale normoxic animals a visible red color when challenged by oxygen deprivation. The promoter regions of the <i>Daphnia</i> globin genes each contain numerous hypoxia response elements (HREs) as potential binding sites for hypoxia-inducible factors (HIFs). <i>Daphnia</i> HIF, bound to human HRE sequences, was detected in extracts from hypoxic (red), but not normoxic (pale), animals. Taking advantage of the phylogenetically conserved HIF/HRE recognition, we employed heterologous transfections of HIF-expressing human and <i>Drosophila</i> cells to model HIF signaling in <i>Daphnia</i>. These experiments revealed that three functional HREs within the promoter of the <i>D. magna</i> globin-2 gene cooperate for maximal hypoxic induction of a downstream luciferase reporter gene. Two of these three <i>cis</i>-elements, at promoter positions -258 and -107, are able to specifically bind human, <i>Drosophila</i>, or <i>Daphnia</i> HIF complexes <i>in vitro</i>. The same two sites are also necessary for maximal induction of reporter transcription under low oxygen tension in the presence of either endogenous human or overexpressed <i>Drosophila</i> HIF proteins. The third motif of the globin-2 gene promoter, a CACGTG palindrome at position -146, functions as a docking site for an unknown constitutive transcription factor. In human cells, this -146 complex interferes with HIF occupancy at the adjacent -107 HRE and thus controls the extent of HIF-mediated hypoxic activation of the downstream target." @default.
• W2097476078 created "2016-06-24" @default.
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• W2097476078 date "2004-08-01" @default.
• W2097476078 modified "2023-10-16" @default.
• W2097476078 title "Hypoxia-induced Synthesis of Hemoglobin in the Crustacean Daphnia magna Is Hypoxia-inducible Factor-dependent" @default.
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• W2097476078 cites W1935776831 @default.
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• W2097476078 cites W1967552166 @default.
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• W2097476078 doi "https://doi.org/10.1074/jbc.m403981200" @default.
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