FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097478859> ?p ?o ?g. }

• W2097478859 endingPage "9054" @default.
• W2097478859 startingPage "9044" @default.
• W2097478859 abstract "ABSTRACT Clearance of hepatitis D virus (HDV) viremia leads to disease remission. Large hepatitis delta antigen (L-HDAg) has been reported to activate transforming growth factor β, which may induce epithelial-mesenchymal transition (EMT) and fibrogenesis. This study analyzed serum HDV RNA “quasispecies” in HDV-infected patients at two stages of infection: before and after alanine aminotransferase (ALT) elevations. Included in the study were four patients who went into remission after ALT elevation and three patients who did not go into remission and progressed to cirrhosis or hepatocellular carcinoma. Full-length HDV cDNA clones were obtained from the most abundant HDV RNA species at the pre- and post-ALT elevation stages. Using an in vitro model consisting of Huh-7 cells transfected with cloned HDV cDNAs, the pre- or post-ALT elevation dominant HDV RNA species were characterized for (i) their replication capacity by measuring HDV RNA and HDAg levels in transfected cells and (ii) their capacity to induce EMT by measuring the levels of the mesenchymal-cell-specific protein vimentin, the EMT regulators twist and snail, and the epithelial-cell-specific protein E-cadherin. Results show that in patients in remission, the post-ALT elevation dominant HDV RNA species had a lower replication capacity in vitro and lower EMT activity than their pre-ALT elevation counterparts. This was not true of patients who did not go into remission. The expression of L-HDAg, but not small HDAg, increased the expression of the EMT-related proteins. It is concluded that in chronically infected patients, HDV quasispecies with a low replication capacity and low EMT activity are associated with disease remission." @default.
• W2097478859 created "2016-06-24" @default.
• W2097478859 creator A5008219887 @default.
• W2097478859 creator A5019875514 @default.
• W2097478859 creator A5022537148 @default.
• W2097478859 creator A5047674805 @default.
• W2097478859 creator A5051608779 @default.
• W2097478859 creator A5061268760 @default.
• W2097478859 date "2012-09-01" @default.
• W2097478859 modified "2023-10-18" @default.
• W2097478859 title "Hepatitis D Virus Isolates with Low Replication and Epithelial-Mesenchymal Transition-Inducing Activity Are Associated with Disease Remission" @default.
• W2097478859 cites W1510107034 @default.
• W2097478859 cites W1608621108 @default.
• W2097478859 cites W1631028738 @default.
• W2097478859 cites W1664798331 @default.
• W2097478859 cites W1799645680 @default.
• W2097478859 cites W1900802350 @default.
• W2097478859 cites W1964252716 @default.
• W2097478859 cites W1968642409 @default.
• W2097478859 cites W1987515540 @default.
• W2097478859 cites W1998385222 @default.
• W2097478859 cites W2004324989 @default.
• W2097478859 cites W2007912885 @default.
• W2097478859 cites W2014070629 @default.
• W2097478859 cites W2038430559 @default.
• W2097478859 cites W2043142612 @default.
• W2097478859 cites W2049653756 @default.
• W2097478859 cites W2069929606 @default.
• W2097478859 cites W2070569872 @default.
• W2097478859 cites W2071609983 @default.
• W2097478859 cites W2072358219 @default.
• W2097478859 cites W2080628222 @default.
• W2097478859 cites W2093157637 @default.
• W2097478859 cites W2097819518 @default.
• W2097478859 cites W2102785551 @default.
• W2097478859 cites W2104239713 @default.
• W2097478859 cites W2109834815 @default.
• W2097478859 cites W2111323301 @default.
• W2097478859 cites W2117262499 @default.
• W2097478859 cites W2126232334 @default.
• W2097478859 cites W2133202656 @default.
• W2097478859 cites W2141448996 @default.
• W2097478859 cites W2142599648 @default.
• W2097478859 cites W2157441620 @default.
• W2097478859 cites W2170776372 @default.
• W2097478859 cites W2178777686 @default.
• W2097478859 cites W2335838053 @default.
• W2097478859 cites W4255712601 @default.
• W2097478859 doi "https://doi.org/10.1128/jvi.00130-12" @default.
• W2097478859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3416108" @default.
• W2097478859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22674995" @default.
• W2097478859 hasPublicationYear "2012" @default.
• W2097478859 type Work @default.
• W2097478859 sameAs 2097478859 @default.
• W2097478859 citedByCount "10" @default.
• W2097478859 countsByYear W20974788592013 @default.
• W2097478859 countsByYear W20974788592014 @default.
• W2097478859 countsByYear W20974788592015 @default.
• W2097478859 countsByYear W20974788592020 @default.
• W2097478859 countsByYear W20974788592021 @default.
• W2097478859 countsByYear W20974788592022 @default.
• W2097478859 countsByYear W20974788592023 @default.
• W2097478859 crossrefType "journal-article" @default.
• W2097478859 hasAuthorship W2097478859A5008219887 @default.
• W2097478859 hasAuthorship W2097478859A5019875514 @default.
• W2097478859 hasAuthorship W2097478859A5022537148 @default.
• W2097478859 hasAuthorship W2097478859A5047674805 @default.
• W2097478859 hasAuthorship W2097478859A5051608779 @default.
• W2097478859 hasAuthorship W2097478859A5061268760 @default.
• W2097478859 hasBestOaLocation W20974788591 @default.
• W2097478859 hasConcept C104317684 @default.
• W2097478859 hasConcept C121608353 @default.
• W2097478859 hasConcept C126322002 @default.
• W2097478859 hasConcept C140704245 @default.
• W2097478859 hasConcept C14500911 @default.
• W2097478859 hasConcept C147447768 @default.
• W2097478859 hasConcept C153911025 @default.
• W2097478859 hasConcept C159047783 @default.
• W2097478859 hasConcept C203014093 @default.
• W2097478859 hasConcept C204232928 @default.
• W2097478859 hasConcept C2522874641 @default.
• W2097478859 hasConcept C2776408679 @default.
• W2097478859 hasConcept C2777214474 @default.
• W2097478859 hasConcept C2778019345 @default.
• W2097478859 hasConcept C2779013556 @default.
• W2097478859 hasConcept C502942594 @default.
• W2097478859 hasConcept C54009773 @default.
• W2097478859 hasConcept C54355233 @default.
• W2097478859 hasConcept C55493867 @default.
• W2097478859 hasConcept C67705224 @default.
• W2097478859 hasConcept C71924100 @default.
• W2097478859 hasConcept C76419328 @default.
• W2097478859 hasConcept C81885089 @default.
• W2097478859 hasConcept C86803240 @default.
• W2097478859 hasConceptScore W2097478859C104317684 @default.
• W2097478859 hasConceptScore W2097478859C121608353 @default.
• W2097478859 hasConceptScore W2097478859C126322002 @default.
• W2097478859 hasConceptScore W2097478859C140704245 @default.

• next