FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097480079> ?p ?o ?g. }

• W2097480079 endingPage "8125" @default.
• W2097480079 startingPage "8111" @default.
• W2097480079 abstract "We have examined gating and pharmacological characteristics of somatic K+ channels in fast-spiking interneurons and regularly spiking principal neurons of hippocampal slices. In nucleated patches isolated from basket cells of the dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive to tetraethylammonium (TEA) and 4-aminopyridine (4-AP) (half-maximal inhibitory concentrations <0.1 mM) predominated, contributing an average of 58% to the total K+ current in these cells. By contrast, in pyramidal neurons of the CA1 region a rapidly inactivating A-type K+ current component that was TEA-resistant prevailed, contributing 61% to the total K+ current. Both types of neurons also showed small amounts of the K+ current component mainly found in the other type of neuron and, in addition, a slow delayed rectifier K+ current component with intermediate properties (slow inactivation, intermediate sensitivity to TEA). Single-cell RT-PCR analysis of mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal neurons. In contrast, Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of pyramidal neurons but only in 55% of interneurons. Selective block of fast delayed rectifier K+ channels, presumably assembled from Kv3 subunits, by 4-AP reduced substantially the action potential frequency in interneurons. These results indicate that the differential expression of Kv3 and Kv4 subunits shapes the action potential phenotypes of principal neurons and interneurons in the cortex." @default.
• W2097480079 created "2016-06-24" @default.
• W2097480079 creator A5002516562 @default.
• W2097480079 creator A5004432141 @default.
• W2097480079 creator A5055139782 @default.
• W2097480079 creator A5062528345 @default.
• W2097480079 creator A5064762475 @default.
• W2097480079 date "1998-10-15" @default.
• W2097480079 modified "2023-10-14" @default.
• W2097480079 title "Functional and Molecular Differences between Voltage-Gated K⁺Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus" @default.
• W2097480079 cites W1485442548 @default.
• W2097480079 cites W1554730844 @default.
• W2097480079 cites W1570612396 @default.
• W2097480079 cites W1582023498 @default.
• W2097480079 cites W1646051950 @default.
• W2097480079 cites W1782707686 @default.
• W2097480079 cites W1813308793 @default.
• W2097480079 cites W1830737945 @default.
• W2097480079 cites W1885378673 @default.
• W2097480079 cites W1904956466 @default.
• W2097480079 cites W1960266861 @default.
• W2097480079 cites W1967175787 @default.
• W2097480079 cites W1968370453 @default.
• W2097480079 cites W1975424106 @default.
• W2097480079 cites W1979103094 @default.
• W2097480079 cites W1982728552 @default.
• W2097480079 cites W1987182471 @default.
• W2097480079 cites W2024617272 @default.
• W2097480079 cites W2026551523 @default.
• W2097480079 cites W2039109065 @default.
• W2097480079 cites W2045336331 @default.
• W2097480079 cites W2045882841 @default.
• W2097480079 cites W2048528277 @default.
• W2097480079 cites W2054855795 @default.
• W2097480079 cites W2055164382 @default.
• W2097480079 cites W2056661320 @default.
• W2097480079 cites W2059612988 @default.
• W2097480079 cites W207930444 @default.
• W2097480079 cites W2080803688 @default.
• W2097480079 cites W2082315659 @default.
• W2097480079 cites W2102006233 @default.
• W2097480079 cites W2102193338 @default.
• W2097480079 cites W2102994933 @default.
• W2097480079 cites W2103587627 @default.
• W2097480079 cites W2109277137 @default.
• W2097480079 cites W2110534885 @default.
• W2097480079 cites W2120610786 @default.
• W2097480079 cites W2130092107 @default.
• W2097480079 cites W2164253634 @default.
• W2097480079 cites W2164303123 @default.
• W2097480079 cites W2332249202 @default.
• W2097480079 cites W2416353909 @default.
• W2097480079 doi "https://doi.org/10.1523/jneurosci.18-20-08111.1998" @default.
• W2097480079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792860" @default.
• W2097480079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9763458" @default.
• W2097480079 hasPublicationYear "1998" @default.
• W2097480079 type Work @default.
• W2097480079 sameAs 2097480079 @default.
• W2097480079 citedByCount "369" @default.
• W2097480079 countsByYear W20974800792012 @default.
• W2097480079 countsByYear W20974800792013 @default.
• W2097480079 countsByYear W20974800792014 @default.
• W2097480079 countsByYear W20974800792015 @default.
• W2097480079 countsByYear W20974800792016 @default.
• W2097480079 countsByYear W20974800792017 @default.
• W2097480079 countsByYear W20974800792018 @default.
• W2097480079 countsByYear W20974800792019 @default.
• W2097480079 countsByYear W20974800792020 @default.
• W2097480079 countsByYear W20974800792021 @default.
• W2097480079 countsByYear W20974800792022 @default.
• W2097480079 countsByYear W20974800792023 @default.
• W2097480079 crossrefType "journal-article" @default.
• W2097480079 hasAuthorship W2097480079A5002516562 @default.
• W2097480079 hasAuthorship W2097480079A5004432141 @default.
• W2097480079 hasAuthorship W2097480079A5055139782 @default.
• W2097480079 hasAuthorship W2097480079A5062528345 @default.
• W2097480079 hasAuthorship W2097480079A5064762475 @default.
• W2097480079 hasBestOaLocation W20974800791 @default.
• W2097480079 hasConcept C12554922 @default.
• W2097480079 hasConcept C147944092 @default.
• W2097480079 hasConcept C148762608 @default.
• W2097480079 hasConcept C169760540 @default.
• W2097480079 hasConcept C17077164 @default.
• W2097480079 hasConcept C178790620 @default.
• W2097480079 hasConcept C185263204 @default.
• W2097480079 hasConcept C185592680 @default.
• W2097480079 hasConcept C2776464000 @default.
• W2097480079 hasConcept C2778437258 @default.
• W2097480079 hasConcept C2778794669 @default.
• W2097480079 hasConcept C2779296341 @default.
• W2097480079 hasConcept C2780922449 @default.
• W2097480079 hasConcept C2781161787 @default.
• W2097480079 hasConcept C2781295685 @default.
• W2097480079 hasConcept C517785266 @default.
• W2097480079 hasConcept C83743174 @default.
• W2097480079 hasConcept C86803240 @default.
• W2097480079 hasConceptScore W2097480079C12554922 @default.
• W2097480079 hasConceptScore W2097480079C147944092 @default.

• next