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- W2097483903 endingPage "334" @default.
- W2097483903 startingPage "319" @default.
- W2097483903 abstract "Previously considered a human commensal, Staphylococcus epidermidis is a frequent cause of nosocomial infections and the most common cause of device-related infections. Because the expression of toxins and other obvious virulence factors is less in S. epidermidis, the biofilm-forming capacity is its major virulence factor. Biofilm growth is characterized by high resistance to antimicrobial agents and host immune responses, making biofilm eradication tremendously difficult. The increasing prevalence of multidrug-resistant S. epidermidis strains additionally hampers antimicrobial therapy. Therefore, immunoprophylaxis and immunotherapy targeting factors expressed at some point in biofilm formation might offer new tools to combat S. epidermidis infections. So far, a limited number of targets have been examined for their immunotherapeutic potential. In this review, we focus on the already tested and possible targets for vaccine development, discuss the accompanying challenges and speculate on future possibilities with respect to immunotherapeutic solutions to deal with S. epidermidis infections." @default.
- W2097483903 created "2016-06-24" @default.
- W2097483903 creator A5004731819 @default.
- W2097483903 creator A5012535857 @default.
- W2097483903 creator A5018541096 @default.
- W2097483903 creator A5084366321 @default.
- W2097483903 date "2012-01-01" @default.
- W2097483903 modified "2023-10-16" @default.
- W2097483903 title "Immunoprophylaxis and immunotherapy of<i>Staphylococcus epidermidis</i>infections: challenges and prospects" @default.
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