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• W2097487767 abstract "Previous studies have shown that lactate dehydrogenase-A (LDH-A) is strongly expressed in several malignancies, that LDH-A expression is associated with poor prognosis, and that LDH-A inhibition severely diminishes tumorigenicity. However, little is known about the implications of LDH-A expression in intrahepatic cholangiocarcinoma. The purpose of this study was to investigate the expression of LDH-A and to clarify its effect on intrahepatic cholangiocarcinoma. We studied the expression of LDH-A in tissue samples from patients with intrahepatic cholangiocarcinoma (n = 54) using the ultrasensitive surfactant protein (S-P) immunohistochemical method. We then inhibited LDH-A using small hairpin RNA (shRNA) in the cholangiocarcinoma cell line HuCCT-1 in vitro to study the role it plays in promoting growth and escaping apoptosis. We report that LDH-A was overexpressed in 52 of 54 (96%) paraffin-embedded cancer tissue samples and 0 of 54 para-carcinoma tissue samples. Reduction of LDH-A by RNA interference (RNAi) inhibited cell growth and induced apoptosis in HuCCT-1 cells. This result correlated with the elevation of cytoplasmic reactive oxygen species (ROS) levels. LDH-A expression is closely correlated with histopathological variables of intrahepatic cholangiocarcinoma, indicating that LDH-A may serve as a new treatment target." @default.
• W2097487767 created "2016-06-24" @default.
• W2097487767 creator A5042589835 @default.
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• W2097487767 date "2014-03-31" @default.
• W2097487767 modified "2023-10-16" @default.
• W2097487767 title "Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment" @default.
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• W2097487767 doi "https://doi.org/10.1186/1477-7819-12-78" @default.
• W2097487767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230420" @default.
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