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- W2097498332 abstract "Angioblasts, the precursor cells that comprise the endothelial layer of blood vessels, arise from a purely mesodermal population. Individual angioblasts coalesce to form the primary vascular plexus through a process called vasculogenesis. A number of reports in the literature suggest that signals from the adjacent endoderm are necessary to induce angioblast specification within the mesoderm. We present evidence, using both embryological and molecular techniques, indicating that endoderm is not necessary for the induction of angioblasts. Xenopus embryos that had endoderm physically removed at the onset of gastrulation still express vascular markers. Furthermore, animal caps stimulated with bFGF form angioblasts in the absence of any detectable endodermal markers. These results show that endoderm is not required for the initial formation of angioblasts. While Xenopus embryos lacking endoderm contain aggregates of angioblasts, these angioblasts fail to assemble into endothelial tubes. Endothelial tube formation can be rescued, however, by implantation of endodermal tissue from sibling embryos. Based on these studies in Xenopus, and corroborating experiments using the quail embryo, we conclude that endoderm is not required for angioblast specification, but does play an essential role in the formation of vascular tubes." @default.
- W2097498332 created "2016-06-24" @default.
- W2097498332 creator A5071088038 @default.
- W2097498332 creator A5075297399 @default.
- W2097498332 date "2002-02-01" @default.
- W2097498332 modified "2023-10-13" @default.
- W2097498332 title "Endoderm is required for vascular endothelial tube formation, but not for angioblast specification" @default.
- W2097498332 cites W114253039 @default.
- W2097498332 cites W127203650 @default.
- W2097498332 cites W1495287184 @default.
- W2097498332 cites W1495424955 @default.
- W2097498332 cites W1783580437 @default.
- W2097498332 cites W1802095065 @default.
- W2097498332 cites W1819473060 @default.
- W2097498332 cites W1838110840 @default.
- W2097498332 cites W1844495809 @default.
- W2097498332 cites W1845107299 @default.
- W2097498332 cites W188190689 @default.
- W2097498332 cites W1927305112 @default.
- W2097498332 cites W1967154475 @default.
- W2097498332 cites W1970254941 @default.
- W2097498332 cites W1971760578 @default.
- W2097498332 cites W1981421570 @default.
- W2097498332 cites W1984020249 @default.
- W2097498332 cites W1986313393 @default.
- W2097498332 cites W1988688040 @default.
- W2097498332 cites W1991050551 @default.
- W2097498332 cites W1995187075 @default.
- W2097498332 cites W1997451475 @default.
- W2097498332 cites W1997813854 @default.
- W2097498332 cites W1998647523 @default.
- W2097498332 cites W2003841601 @default.
- W2097498332 cites W2006358600 @default.
- W2097498332 cites W2008004968 @default.
- W2097498332 cites W2008467615 @default.
- W2097498332 cites W2011819102 @default.
- W2097498332 cites W2014048648 @default.
- W2097498332 cites W2015017554 @default.
- W2097498332 cites W2016000298 @default.
- W2097498332 cites W2019564264 @default.
- W2097498332 cites W2027018081 @default.
- W2097498332 cites W2030608150 @default.
- W2097498332 cites W2040751142 @default.
- W2097498332 cites W2044095291 @default.
- W2097498332 cites W2045247659 @default.
- W2097498332 cites W2046516822 @default.
- W2097498332 cites W2051669235 @default.
- W2097498332 cites W2054156740 @default.
- W2097498332 cites W2056524045 @default.
- W2097498332 cites W2056769082 @default.
- W2097498332 cites W2060660919 @default.
- W2097498332 cites W2061202370 @default.
- W2097498332 cites W2068224181 @default.
- W2097498332 cites W2072636418 @default.
- W2097498332 cites W2075559846 @default.
- W2097498332 cites W2075714512 @default.
- W2097498332 cites W2075830266 @default.
- W2097498332 cites W2078916993 @default.
- W2097498332 cites W2081939122 @default.
- W2097498332 cites W2093221121 @default.
- W2097498332 cites W2093498435 @default.
- W2097498332 cites W2095856734 @default.
- W2097498332 cites W2096667049 @default.
- W2097498332 cites W2117314116 @default.
- W2097498332 cites W2122034269 @default.
- W2097498332 cites W2130422603 @default.
- W2097498332 cites W2131301194 @default.
- W2097498332 cites W2136023141 @default.
- W2097498332 cites W2138541587 @default.
- W2097498332 cites W2140034535 @default.
- W2097498332 cites W2141805102 @default.
- W2097498332 cites W2145150521 @default.
- W2097498332 cites W2161365564 @default.
- W2097498332 cites W2166156136 @default.
- W2097498332 cites W2166658859 @default.
- W2097498332 cites W2186646946 @default.
- W2097498332 cites W2284905211 @default.
- W2097498332 cites W2336444604 @default.
- W2097498332 cites W2346055678 @default.
- W2097498332 cites W2417340472 @default.
- W2097498332 cites W2426114041 @default.
- W2097498332 cites W2992132817 @default.
- W2097498332 cites W32484607 @default.
- W2097498332 cites W4206421363 @default.
- W2097498332 cites W4213137378 @default.
- W2097498332 cites W4249388929 @default.
- W2097498332 doi "https://doi.org/10.1242/dev.129.3.775" @default.
- W2097498332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11830576" @default.
- W2097498332 hasPublicationYear "2002" @default.
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