Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097500515> ?p ?o ?g. }
- W2097500515 endingPage "1033" @default.
- W2097500515 startingPage "1024" @default.
- W2097500515 abstract "Prompt removal of unwanted cells, such as senescent, damaged, genetically mutated, or virus infected cells, is crucial for the maintenance of liver health. This process is naturally achieved through a highly regulated programmed form of cell death called apoptosis. In healthy organisms, the number of cells eliminated by apoptosis equals the number of cells generated by mitosis, ensuring the proper organ homeostasis. In addition, “physiological” apoptosis allows the removal of cells with virtually no release of proinflammatory cytokines and minimal immune response. However, in pathophysiological situations, the balance between cell proliferation and cell death is often altered, with the consequent loss of tissue homeostasis and the onset of several liver diseases. Insufficient apoptosis, with failure of removal of cells carrying mutated genes, and unregulated proliferation within the context of a persistent inflammatory milieu, can promote the development of liver and biliary cancer.1–4 Paradoxically, a chronic apoptotic stimulus can also predispose to cancer development due to the high rate of regeneration invoked in the tissue, which elevates the risk of mitotic errors. In contrast, excessive and/or sustained apoptosis can lead to acute injuries, such as fulminant hepatitis and reperfusion damage,5,6 or even chronic sustained injuries, such as alcoholic liver disease, cholestatic liver disease, and viral hepatitis.7–10 Therefore, therapeutic strategies to inhibit apoptosis in liver injury, or selectively kill malignant cells in tumours, have the potential to provide a powerful tool for the treatment of liver disease. Indeed, with an improved understanding of the molecular pathways and the pathophysiological role of apoptosis, new drugs aimed at therapeutically modulating apoptosis are now available for clinical trials and/or as new therapeutic options for the treatment of several human diseases. In this review, we will focus on the role of apoptosis in selected liver diseases, such as alcoholic liver …" @default.
- W2097500515 created "2016-06-24" @default.
- W2097500515 creator A5004470985 @default.
- W2097500515 creator A5027503426 @default.
- W2097500515 date "2005-07-01" @default.
- W2097500515 modified "2023-09-30" @default.
- W2097500515 title "Apoptosis: a mechanism of acute and chronic liver injury" @default.
- W2097500515 cites W143341100 @default.
- W2097500515 cites W1502813670 @default.
- W2097500515 cites W1549863768 @default.
- W2097500515 cites W1571910978 @default.
- W2097500515 cites W1589415602 @default.
- W2097500515 cites W1593219141 @default.
- W2097500515 cites W1603067300 @default.
- W2097500515 cites W1642763135 @default.
- W2097500515 cites W1862543179 @default.
- W2097500515 cites W1913661233 @default.
- W2097500515 cites W1963577430 @default.
- W2097500515 cites W1968893128 @default.
- W2097500515 cites W1970945458 @default.
- W2097500515 cites W1973109581 @default.
- W2097500515 cites W1974303227 @default.
- W2097500515 cites W1974312247 @default.
- W2097500515 cites W1975007343 @default.
- W2097500515 cites W1975882704 @default.
- W2097500515 cites W1977567003 @default.
- W2097500515 cites W1978018492 @default.
- W2097500515 cites W1979998867 @default.
- W2097500515 cites W1981182552 @default.
- W2097500515 cites W1982308850 @default.
- W2097500515 cites W1984077928 @default.
- W2097500515 cites W1984547206 @default.
- W2097500515 cites W1986568749 @default.
- W2097500515 cites W1993899393 @default.
- W2097500515 cites W1994144074 @default.
- W2097500515 cites W1994611236 @default.
- W2097500515 cites W1994888307 @default.
- W2097500515 cites W2000093730 @default.
- W2097500515 cites W2003478049 @default.
- W2097500515 cites W2007207243 @default.
- W2097500515 cites W2008779414 @default.
- W2097500515 cites W2010139831 @default.
- W2097500515 cites W2010334438 @default.
- W2097500515 cites W2012173926 @default.
- W2097500515 cites W2013656487 @default.
- W2097500515 cites W2014246786 @default.
- W2097500515 cites W2014617922 @default.
- W2097500515 cites W2015464799 @default.
- W2097500515 cites W2016198585 @default.
- W2097500515 cites W2018251493 @default.
- W2097500515 cites W2023036977 @default.
- W2097500515 cites W2024507347 @default.
- W2097500515 cites W2025128734 @default.
- W2097500515 cites W2025665882 @default.
- W2097500515 cites W2026338728 @default.
- W2097500515 cites W2027482251 @default.
- W2097500515 cites W2028135427 @default.
- W2097500515 cites W2029126990 @default.
- W2097500515 cites W2034188379 @default.
- W2097500515 cites W2034365043 @default.
- W2097500515 cites W2036075903 @default.
- W2097500515 cites W2036339298 @default.
- W2097500515 cites W2038417476 @default.
- W2097500515 cites W2039355845 @default.
- W2097500515 cites W2042316019 @default.
- W2097500515 cites W2042812804 @default.
- W2097500515 cites W2042949419 @default.
- W2097500515 cites W2045175932 @default.
- W2097500515 cites W2045796964 @default.
- W2097500515 cites W2046056065 @default.
- W2097500515 cites W2049110705 @default.
- W2097500515 cites W2049173074 @default.
- W2097500515 cites W2056316765 @default.
- W2097500515 cites W2056924500 @default.
- W2097500515 cites W2058091579 @default.
- W2097500515 cites W2061025874 @default.
- W2097500515 cites W2061920325 @default.
- W2097500515 cites W2062853648 @default.
- W2097500515 cites W2065929630 @default.
- W2097500515 cites W206733600 @default.
- W2097500515 cites W2067534266 @default.
- W2097500515 cites W2068762746 @default.
- W2097500515 cites W2072252062 @default.
- W2097500515 cites W2074060016 @default.
- W2097500515 cites W2080308799 @default.
- W2097500515 cites W2080325240 @default.
- W2097500515 cites W2081828123 @default.
- W2097500515 cites W2083549154 @default.
- W2097500515 cites W2084815601 @default.
- W2097500515 cites W2086121204 @default.
- W2097500515 cites W2087877138 @default.
- W2097500515 cites W2089907961 @default.
- W2097500515 cites W2091440199 @default.
- W2097500515 cites W2094053196 @default.
- W2097500515 cites W2096653553 @default.
- W2097500515 cites W2099956255 @default.
- W2097500515 cites W2105115684 @default.
- W2097500515 cites W2105253445 @default.