FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097520737> ?p ?o ?g. }

• W2097520737 endingPage "2156" @default.
• W2097520737 startingPage "2151" @default.
• W2097520737 abstract "We investigated the contribution of the xeroderma pigmentosum group C (XPC) gene to DNA repair. We stably transfected XPC cells (XP4PA-SV-EB) with XPC cDNA and selected a partially corrected (XP4PA-SE1) and a fully corrected (XP4PA-SE2) clone. Cell survival after UVC (254 nm) exposure was low for XP4PA-SV-EB, intermediate for XP4PA-SE1, and normal for XP4PA-SE2 cells. XP4PA-SV-EB cells had undetectable XPC mRNA and protein levels. XP4PA-SE1 cells had 130% of normal mRNA but 25% of normal protein levels, whereas XP4PA-SE2 cells had an 18-fold mRNA overexpression and normal XPC protein levels compared with normal cells. We measured cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PP) by using specific mAbs and the ELISA technique. XP4PA-SV-EB cells had no detectable removal of CPD or 6-4PP from their global genome by 24 h after 30 J/m(2) UVC exposure. The partially corrected XP4PA-SE1 cells had normal repair of CPD but minimal repair of 6-4PP by 24 h, whereas the fully corrected XP4PA-SE2 cells regained normal CPD and 6-4PP repair capacities. We also exposed pRSVcat plasmid to UVC (to induce CPD and 6-4PP), to UVC + photolyase (to leave only 6-4PP on the plasmid), or to UVB + acetophenone (to induce only CPD). Host cell reactivation of UVB + acetophenone-, but not of UVC + photolyase-treated plasmids was normal in XP4PA-SE1 cells. Thus, increasing XPC gene expression leads to selective repair of CPD in the global genome. Undetectable XPC protein is associated with no repair of CPD or 6-4PP, detectable but subnormal XPC protein levels reconstitute CPD but not 6-4PP repair, and normal XPC protein levels fully reconstitute both CPD and 6-4PP repair." @default.
• W2097520737 created "2016-06-24" @default.
• W2097520737 creator A5005457224 @default.
• W2097520737 creator A5054677846 @default.
• W2097520737 creator A5059390771 @default.
• W2097520737 creator A5078105548 @default.
• W2097520737 date "2000-02-11" @default.
• W2097520737 modified "2023-09-25" @default.
• W2097520737 title "The xeroderma pigmentosum group C gene leads to selective repair of cyclobutane pyrimidine dimers rather than 6-4 photoproducts" @default.
• W2097520737 cites W1005028082 @default.
• W2097520737 cites W1485000848 @default.
• W2097520737 cites W1531823089 @default.
• W2097520737 cites W1570121117 @default.
• W2097520737 cites W1578294816 @default.
• W2097520737 cites W1889725400 @default.
• W2097520737 cites W1966284016 @default.
• W2097520737 cites W1971109667 @default.
• W2097520737 cites W1975290514 @default.
• W2097520737 cites W1975365355 @default.
• W2097520737 cites W1976538128 @default.
• W2097520737 cites W1978674906 @default.
• W2097520737 cites W1979521511 @default.
• W2097520737 cites W1982232706 @default.
• W2097520737 cites W1983290059 @default.
• W2097520737 cites W1989064758 @default.
• W2097520737 cites W1989317177 @default.
• W2097520737 cites W1991485455 @default.
• W2097520737 cites W1993495755 @default.
• W2097520737 cites W1996172944 @default.
• W2097520737 cites W1996973786 @default.
• W2097520737 cites W1999602003 @default.
• W2097520737 cites W2018448933 @default.
• W2097520737 cites W2019595755 @default.
• W2097520737 cites W2021485188 @default.
• W2097520737 cites W2021798512 @default.
• W2097520737 cites W2021840723 @default.
• W2097520737 cites W2033000052 @default.
• W2097520737 cites W2033946131 @default.
• W2097520737 cites W2044000184 @default.
• W2097520737 cites W2044036970 @default.
• W2097520737 cites W2056583950 @default.
• W2097520737 cites W2057953406 @default.
• W2097520737 cites W2058933270 @default.
• W2097520737 cites W2065286203 @default.
• W2097520737 cites W2067454860 @default.
• W2097520737 cites W2070821144 @default.
• W2097520737 cites W2073564054 @default.
• W2097520737 cites W2081049803 @default.
• W2097520737 cites W2083531185 @default.
• W2097520737 cites W2101906532 @default.
• W2097520737 cites W2117808727 @default.
• W2097520737 cites W2124227044 @default.
• W2097520737 cites W2132453608 @default.
• W2097520737 cites W2138092377 @default.
• W2097520737 cites W2140118545 @default.
• W2097520737 cites W2172916891 @default.
• W2097520737 cites W2173751778 @default.
• W2097520737 cites W4251391836 @default.
• W2097520737 doi "https://doi.org/10.1073/pnas.040559697" @default.
• W2097520737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15769" @default.
• W2097520737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10681431" @default.
• W2097520737 hasPublicationYear "2000" @default.
• W2097520737 type Work @default.
• W2097520737 sameAs 2097520737 @default.
• W2097520737 citedByCount "81" @default.
• W2097520737 countsByYear W20975207372012 @default.
• W2097520737 countsByYear W20975207372013 @default.
• W2097520737 countsByYear W20975207372014 @default.
• W2097520737 countsByYear W20975207372015 @default.
• W2097520737 countsByYear W20975207372016 @default.
• W2097520737 countsByYear W20975207372017 @default.
• W2097520737 countsByYear W20975207372018 @default.
• W2097520737 countsByYear W20975207372019 @default.
• W2097520737 countsByYear W20975207372020 @default.
• W2097520737 countsByYear W20975207372021 @default.
• W2097520737 countsByYear W20975207372022 @default.
• W2097520737 countsByYear W20975207372023 @default.
• W2097520737 crossrefType "journal-article" @default.
• W2097520737 hasAuthorship W2097520737A5005457224 @default.
• W2097520737 hasAuthorship W2097520737A5054677846 @default.
• W2097520737 hasAuthorship W2097520737A5059390771 @default.
• W2097520737 hasAuthorship W2097520737A5078105548 @default.
• W2097520737 hasBestOaLocation W20975207371 @default.
• W2097520737 hasConcept C104317684 @default.
• W2097520737 hasConcept C104451858 @default.
• W2097520737 hasConcept C134935766 @default.
• W2097520737 hasConcept C143425029 @default.
• W2097520737 hasConcept C153911025 @default.
• W2097520737 hasConcept C165204475 @default.
• W2097520737 hasConcept C167975912 @default.
• W2097520737 hasConcept C178790620 @default.
• W2097520737 hasConcept C185592680 @default.
• W2097520737 hasConcept C22744801 @default.
• W2097520737 hasConcept C2778378917 @default.
• W2097520737 hasConcept C2780377690 @default.
• W2097520737 hasConcept C2780378348 @default.
• W2097520737 hasConcept C54009773 @default.
• W2097520737 hasConcept C552990157 @default.

• next