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- W2097523243 abstract "Abstract Background: In patients with dilated cardiomyopathy (DCM), elevated plasma levels of tumor necrosis factor‐α (TNF‐α) are associated with poor prognosis. The terminal complement complex (C5b‐9) stimulates myocardial TNF‐α expression. Aims: To investigate whether myocardial TNF‐α and C5b‐9 expression correlate with clinical outcome in DCM. Methods and results: 71 patients with DCM underwent myocardial biopsy. Biopsies were analyzed for TNF‐α, C5b‐9, markers of inflammation and for viral genome. Patients were divided into three groups according to biopsy results: group A: no TNF‐α and no C5b‐9; group B: TNF‐α or C5b‐9; and group C: TNF‐α and C5b‐9. NYHA classification, ECG and echocardiography were documented. Patients received conventional treatment of heart failure and, in a few cases, additional treatment with interferon β 1b (virus positive) or prednisolone (inflammatory DCM). There were 13 patients (18%) in group A, 19 patients (27%) in group B, and 39 patients (55%) in group C. All groups had a similar and significant improvement in NYHA classification and echocardiographic parameters. TNF‐α and C5b‐9 did not significantly correlate with the presence of viral genome or with markers of inflammation. Conclusion: TNF‐α and C5b‐9 are widely distributed in the myocardium of DCM patients. Neither of the antigens correlates with clinical outcome. Myocardial TNF‐α may not be a useful prognostic marker in DCM." @default.
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- W2097523243 date "2007-01-01" @default.
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- W2097523243 title "Prognostic role of myocardial tumor necrosis factor-alpha and terminal complement complex expression in patients with dilated cardiomyopathy" @default.
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- W2097523243 doi "https://doi.org/10.1016/j.ejheart.2006.04.001" @default.
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