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- W2097533480 abstract "ABSTRACT Conventional drugs used in cancer therapy have extended the survival time of patients, however mortality has not significantly decreased. It is evident that there is a need to develop a new, more effective and less toxic compounds in cancer treatment. A promising new approach is based on the deciphering of biological information encoded in β-galactose-containing glycoconjugates and to find out the biological role(s) of carbohydrate binding proteins/galectins, which able to convert encoded information into biological and pathological reactions. Galectins can alter cellular interactions and have important roles in cell cycle, apoptosis and metastases. This review aimed to provide an overview on the potential advantages concerning understanding the mechanism of action of galectin-3 (gal-3) as a therapeutic agent for cancer. Galectin-3 has been found to be upregulated in many types of cancer including colon, gastric, renal and non-small cell lung cancer. Results of several studies indicating that gal-3 plays a dynamic role in the tumorogenesis and metastatic process, and showing that blockers/inhibitors of gal-3 could have important therapeutic potential in cancer." @default.
- W2097533480 created "2016-06-24" @default.
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- W2097533480 date "2015-01-01" @default.
- W2097533480 modified "2023-09-24" @default.
- W2097533480 title "Carbohydrate-Mediated Drug Targeting-A Review" @default.
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- W2097533480 doi "https://doi.org/10.5455/spatula.20150330105811" @default.
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