FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097534444> ?p ?o ?g. }

• W2097534444 abstract "Many drugs provide their therapeutic action only at specific sites in the body, but are administered in ways that cause the drug's spread throughout the organism. This can lead to serious side effects. Local delivery from an implanted device may avoid these issues, especially if the delivery rate can be tuned according to the need of the patient. We turned to electronically and ionically conducting polymers to design a device that could be implanted and used for local electrically controlled delivery of therapeutics. The conducting polymers in our device allow electronic pulses to be transduced into biological signals, in the form of ionic and molecular fluxes, which provide a way of interfacing biology with electronics. Devices based on conducting polymers and polyelectrolytes have been demonstrated in controlled substance delivery to neural tissue, biosensing, and neural recording and stimulation. While providing proof of principle of bioelectronic integration, such demonstrations have been performed in vitro or in anesthetized animals. Here, we demonstrate the efficacy of an implantable organic electronic delivery device for the treatment of neuropathic pain in an animal model. Devices were implanted onto the spinal cord of rats, and 2 days after implantation, local delivery of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) was initiated. Highly localized delivery resulted in a significant decrease in pain response with low dosage and no observable side effects. This demonstration of organic bioelectronics-based therapy in awake animals illustrates a viable alternative to existing pain treatments, paving the way for future implantable bioelectronic therapeutics." @default.
• W2097534444 created "2016-06-24" @default.
• W2097534444 creator A5006294413 @default.
• W2097534444 creator A5032288058 @default.
• W2097534444 creator A5046742202 @default.
• W2097534444 creator A5074038674 @default.
• W2097534444 creator A5074618817 @default.
• W2097534444 creator A5079455367 @default.
• W2097534444 creator A5088574290 @default.
• W2097534444 date "2015-05-01" @default.
• W2097534444 modified "2023-10-09" @default.
• W2097534444 title "Therapy using implanted organic bioelectronics" @default.
• W2097534444 cites W1567615855 @default.
• W2097534444 cites W1978174847 @default.
• W2097534444 cites W1995526849 @default.
• W2097534444 cites W1996219630 @default.
• W2097534444 cites W2037009531 @default.
• W2097534444 cites W2041481051 @default.
• W2097534444 cites W2047010161 @default.
• W2097534444 cites W2067692467 @default.
• W2097534444 cites W2070216313 @default.
• W2097534444 cites W2074867537 @default.
• W2097534444 cites W2076156211 @default.
• W2097534444 cites W2076664459 @default.
• W2097534444 cites W2079038140 @default.
• W2097534444 cites W2083148567 @default.
• W2097534444 cites W2098942421 @default.
• W2097534444 cites W2112149659 @default.
• W2097534444 cites W2117881244 @default.
• W2097534444 cites W2119693309 @default.
• W2097534444 cites W2120742828 @default.
• W2097534444 cites W2168285845 @default.
• W2097534444 cites W2171516791 @default.
• W2097534444 cites W250001623 @default.
• W2097534444 cites W4255213843 @default.
• W2097534444 doi "https://doi.org/10.1126/sciadv.1500039" @default.
• W2097534444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4640645" @default.
• W2097534444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26601181" @default.
• W2097534444 hasPublicationYear "2015" @default.
• W2097534444 type Work @default.
• W2097534444 sameAs 2097534444 @default.
• W2097534444 citedByCount "151" @default.
• W2097534444 countsByYear W20975344442015 @default.
• W2097534444 countsByYear W20975344442016 @default.
• W2097534444 countsByYear W20975344442017 @default.
• W2097534444 countsByYear W20975344442018 @default.
• W2097534444 countsByYear W20975344442019 @default.
• W2097534444 countsByYear W20975344442020 @default.
• W2097534444 countsByYear W20975344442021 @default.
• W2097534444 countsByYear W20975344442022 @default.
• W2097534444 countsByYear W20975344442023 @default.
• W2097534444 crossrefType "journal-article" @default.
• W2097534444 hasAuthorship W2097534444A5006294413 @default.
• W2097534444 hasAuthorship W2097534444A5032288058 @default.
• W2097534444 hasAuthorship W2097534444A5046742202 @default.
• W2097534444 hasAuthorship W2097534444A5074038674 @default.
• W2097534444 hasAuthorship W2097534444A5074618817 @default.
• W2097534444 hasAuthorship W2097534444A5079455367 @default.
• W2097534444 hasAuthorship W2097534444A5088574290 @default.
• W2097534444 hasBestOaLocation W20975344441 @default.
• W2097534444 hasConcept C136229726 @default.
• W2097534444 hasConcept C160756335 @default.
• W2097534444 hasConcept C166345560 @default.
• W2097534444 hasConcept C169760540 @default.
• W2097534444 hasConcept C171250308 @default.
• W2097534444 hasConcept C192562407 @default.
• W2097534444 hasConcept C197525751 @default.
• W2097534444 hasConcept C2776303644 @default.
• W2097534444 hasConcept C2779820397 @default.
• W2097534444 hasConcept C41008148 @default.
• W2097534444 hasConcept C60515610 @default.
• W2097534444 hasConcept C71924100 @default.
• W2097534444 hasConcept C86803240 @default.
• W2097534444 hasConcept C9390403 @default.
• W2097534444 hasConceptScore W2097534444C136229726 @default.
• W2097534444 hasConceptScore W2097534444C160756335 @default.
• W2097534444 hasConceptScore W2097534444C166345560 @default.
• W2097534444 hasConceptScore W2097534444C169760540 @default.
• W2097534444 hasConceptScore W2097534444C171250308 @default.
• W2097534444 hasConceptScore W2097534444C192562407 @default.
• W2097534444 hasConceptScore W2097534444C197525751 @default.
• W2097534444 hasConceptScore W2097534444C2776303644 @default.
• W2097534444 hasConceptScore W2097534444C2779820397 @default.
• W2097534444 hasConceptScore W2097534444C41008148 @default.
• W2097534444 hasConceptScore W2097534444C60515610 @default.
• W2097534444 hasConceptScore W2097534444C71924100 @default.
• W2097534444 hasConceptScore W2097534444C86803240 @default.
• W2097534444 hasConceptScore W2097534444C9390403 @default.
• W2097534444 hasFunder F4320321030 @default.
• W2097534444 hasFunder F4320322315 @default.
• W2097534444 hasFunder F4320322327 @default.
• W2097534444 hasFunder F4320322581 @default.
• W2097534444 hasIssue "4" @default.
• W2097534444 hasLocation W20975344441 @default.
• W2097534444 hasLocation W20975344442 @default.
• W2097534444 hasLocation W20975344443 @default.
• W2097534444 hasLocation W20975344444 @default.
• W2097534444 hasOpenAccess W2097534444 @default.
• W2097534444 hasPrimaryLocation W20975344441 @default.
• W2097534444 hasRelatedWork W1982209792 @default.

• next