FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097538995> ?p ?o ?g. }

• W2097538995 endingPage "1359" @default.
• W2097538995 startingPage "1350" @default.
• W2097538995 abstract "ABSTRACT Biologically functional clade C envelope (Env) glycoproteins from the chronically (donor) and newly (recipient) infected partners of four heterosexual transmission pairs in Zambia were cloned and characterized previously. In each case, the donor viral quasispecies contained Envs that were resistant to autologous neutralization by contemporaneous plasma, while the recipient Envs were sensitive to neutralizing antibodies in this donor plasma sample. The donor Envs also varied in length, glycosylation, and amino acid sequence of the V1V2 hypervariable domain of gp120, while the recipient Envs were much more homogeneous. To assess the contribution of V1V2 to the neutralization phenotype of the donor Envs, V1V2 domains from neutralization-sensitive recipient Envs were replaced with donor V1V2 domains, and the autologous neutralization sensitivities of the chimeric Envs were evaluated using a virus-pseudotyping assay. Long donor V1V2 domains regulated sensitivity to autologous neutralization, although the effect was dependent on the Env background. Short donor V1V2 domains did not confer neutralization resistance. Primary sequence differences in V2 were also found to influence neutralization sensitivity in one set of recipient Envs. The results demonstrate that expansion of the V1V2 domain is one pathway to escape from autologous neutralization in subtype C Envs. However, V1V2-independent mechanisms of resistance also exist, suggesting that escape is multifaceted in chronic subtype C infection." @default.
• W2097538995 created "2016-06-24" @default.
• W2097538995 creator A5022850119 @default.
• W2097538995 creator A5026220972 @default.
• W2097538995 creator A5042708757 @default.
• W2097538995 creator A5043417678 @default.
• W2097538995 creator A5043775431 @default.
• W2097538995 creator A5086398020 @default.
• W2097538995 date "2007-02-01" @default.
• W2097538995 modified "2023-10-18" @default.
• W2097538995 title "Role of V1V2 and Other Human Immunodeficiency Virus Type 1 Envelope Domains in Resistance to Autologous Neutralization during Clade C Infection" @default.
• W2097538995 cites W1482966474 @default.
• W2097538995 cites W1483105582 @default.
• W2097538995 cites W1486819540 @default.
• W2097538995 cites W1515583692 @default.
• W2097538995 cites W1570776471 @default.
• W2097538995 cites W185743922 @default.
• W2097538995 cites W1928708680 @default.
• W2097538995 cites W1972564175 @default.
• W2097538995 cites W1976950601 @default.
• W2097538995 cites W1990407513 @default.
• W2097538995 cites W1995187084 @default.
• W2097538995 cites W1997677784 @default.
• W2097538995 cites W1999053028 @default.
• W2097538995 cites W2018554207 @default.
• W2097538995 cites W2028234747 @default.
• W2097538995 cites W2032614798 @default.
• W2097538995 cites W2043182977 @default.
• W2097538995 cites W2050433054 @default.
• W2097538995 cites W2050689569 @default.
• W2097538995 cites W2054457238 @default.
• W2097538995 cites W2064703363 @default.
• W2097538995 cites W2073597533 @default.
• W2097538995 cites W2087354758 @default.
• W2097538995 cites W2095497026 @default.
• W2097538995 cites W2095928782 @default.
• W2097538995 cites W2095939962 @default.
• W2097538995 cites W2096003181 @default.
• W2097538995 cites W2098781795 @default.
• W2097538995 cites W2099381548 @default.
• W2097538995 cites W2099576234 @default.
• W2097538995 cites W2106372377 @default.
• W2097538995 cites W2116437423 @default.
• W2097538995 cites W2116831178 @default.
• W2097538995 cites W2125692679 @default.
• W2097538995 cites W2127682720 @default.
• W2097538995 cites W2131039822 @default.
• W2097538995 cites W2133233128 @default.
• W2097538995 cites W2135691292 @default.
• W2097538995 cites W2146672876 @default.
• W2097538995 cites W2147915261 @default.
• W2097538995 cites W2152026267 @default.
• W2097538995 cites W2152281378 @default.
• W2097538995 cites W2152992605 @default.
• W2097538995 cites W2153163225 @default.
• W2097538995 cites W2157210912 @default.
• W2097538995 cites W2157615131 @default.
• W2097538995 cites W2162465939 @default.
• W2097538995 cites W2169201700 @default.
• W2097538995 cites W2171992047 @default.
• W2097538995 doi "https://doi.org/10.1128/jvi.01839-06" @default.
• W2097538995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2169018" @default.
• W2097538995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17079307" @default.
• W2097538995 hasPublicationYear "2007" @default.
• W2097538995 type Work @default.
• W2097538995 sameAs 2097538995 @default.
• W2097538995 citedByCount "130" @default.
• W2097538995 countsByYear W20975389952012 @default.
• W2097538995 countsByYear W20975389952013 @default.
• W2097538995 countsByYear W20975389952014 @default.
• W2097538995 countsByYear W20975389952015 @default.
• W2097538995 countsByYear W20975389952016 @default.
• W2097538995 countsByYear W20975389952017 @default.
• W2097538995 countsByYear W20975389952018 @default.
• W2097538995 countsByYear W20975389952019 @default.
• W2097538995 countsByYear W20975389952020 @default.
• W2097538995 countsByYear W20975389952021 @default.
• W2097538995 countsByYear W20975389952022 @default.
• W2097538995 crossrefType "journal-article" @default.
• W2097538995 hasAuthorship W2097538995A5022850119 @default.
• W2097538995 hasAuthorship W2097538995A5026220972 @default.
• W2097538995 hasAuthorship W2097538995A5042708757 @default.
• W2097538995 hasAuthorship W2097538995A5043417678 @default.
• W2097538995 hasAuthorship W2097538995A5043775431 @default.
• W2097538995 hasAuthorship W2097538995A5086398020 @default.
• W2097538995 hasBestOaLocation W20975389951 @default.
• W2097538995 hasConcept C108625454 @default.
• W2097538995 hasConcept C14086860 @default.
• W2097538995 hasConcept C14500911 @default.
• W2097538995 hasConcept C159047783 @default.
• W2097538995 hasConcept C2522874641 @default.
• W2097538995 hasConcept C2776408679 @default.
• W2097538995 hasConcept C2779261636 @default.
• W2097538995 hasConcept C54355233 @default.
• W2097538995 hasConcept C86803240 @default.
• W2097538995 hasConceptScore W2097538995C108625454 @default.
• W2097538995 hasConceptScore W2097538995C14086860 @default.
• W2097538995 hasConceptScore W2097538995C14500911 @default.

• next