FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097545829> ?p ?o ?g. }

• W2097545829 endingPage "60" @default.
• W2097545829 startingPage "6853" @default.
• W2097545829 abstract "Lymphotoxin (LT) plays an important role in inflammation and lymphoid organ development, though the mechanisms by which it promotes these processes are poorly understood. Toward this end, the biologic activities of a recently generated recombinant murine (m) LT alpha preparation were evaluated. This cytokine preparation was effective at inducing cytotoxicity of WEHI target cells with 50% maximal killing observed with 1.2 ng/ml. mLT alpha also induced the expression of inflammatory mediators in the murine endothelial cell line bEnd.3. rmLT alpha induced expression of the adhesion molecules VCAM, ICAM, E-selectin, and the mucosal addressin cellular adhesion molecule, MAdCAM-1. When mLT alpha, human (h) LT alpha, and mTNF-alpha were compared, mLT alpha was the most potent inducer of MAdCAM-1. None of these cytokines induced the peripheral node addressin, PNAd. mLT alpha also induced expression of the chemokines RANTES, IFN-inducible protein 10 (IP-10), and monocyte chemotactic protein 1 (MCP-1). mRNA levels peaked 4 h following treatment with mLT alpha and declined through the 24-h treatment period. LT alpha also induced chemokine protein within 8 h of treatment, which increased through the 24-h treatment period. These data demonstrate that the proinflammatory effects of LT alpha3 may be mediated in part through the induction of adhesion molecule and chemokine expression. Further, LT alpha3 may promote development of lymphoid tissue through induction of chemokines and the mucosal addressin MAdCAM-1. These data confirm previous observations in transgenic and knockout mice that LT alpha3 in the absence of LT beta carries out unique biologic activities." @default.
• W2097545829 created "2016-06-24" @default.
• W2097545829 creator A5025526800 @default.
• W2097545829 creator A5045335116 @default.
• W2097545829 creator A5045569688 @default.
• W2097545829 creator A5051385259 @default.
• W2097545829 creator A5054325123 @default.
• W2097545829 creator A5061996831 @default.
• W2097545829 date "1998-12-15" @default.
• W2097545829 modified "2023-09-27" @default.
• W2097545829 title "Lymphotoxin alpha3 induces chemokines and adhesion molecules: insight into the role of LT alpha in inflammation and lymphoid organ development." @default.
• W2097545829 cites W141774154 @default.
• W2097545829 cites W1482618304 @default.
• W2097545829 cites W1485469970 @default.
• W2097545829 cites W1506071020 @default.
• W2097545829 cites W1549162285 @default.
• W2097545829 cites W1558861739 @default.
• W2097545829 cites W1562637495 @default.
• W2097545829 cites W1587142652 @default.
• W2097545829 cites W1589180924 @default.
• W2097545829 cites W1597237416 @default.
• W2097545829 cites W1625203433 @default.
• W2097545829 cites W1645125543 @default.
• W2097545829 cites W1648482399 @default.
• W2097545829 cites W1882195644 @default.
• W2097545829 cites W1935356814 @default.
• W2097545829 cites W1963627373 @default.
• W2097545829 cites W1963639967 @default.
• W2097545829 cites W1966657425 @default.
• W2097545829 cites W1970010434 @default.
• W2097545829 cites W1971169128 @default.
• W2097545829 cites W1974005261 @default.
• W2097545829 cites W1997111007 @default.
• W2097545829 cites W2006281076 @default.
• W2097545829 cites W2012487047 @default.
• W2097545829 cites W2012839093 @default.
• W2097545829 cites W2021672885 @default.
• W2097545829 cites W2027344845 @default.
• W2097545829 cites W2028514452 @default.
• W2097545829 cites W2033963584 @default.
• W2097545829 cites W2034794603 @default.
• W2097545829 cites W2041354260 @default.
• W2097545829 cites W2047719515 @default.
• W2097545829 cites W2048706422 @default.
• W2097545829 cites W2057379124 @default.
• W2097545829 cites W2076505832 @default.
• W2097545829 cites W2081099685 @default.
• W2097545829 cites W2088094253 @default.
• W2097545829 cites W2090076622 @default.
• W2097545829 cites W2092512708 @default.
• W2097545829 cites W2099748840 @default.
• W2097545829 cites W2108743612 @default.
• W2097545829 cites W2109577352 @default.
• W2097545829 cites W2111680926 @default.
• W2097545829 cites W2114123652 @default.
• W2097545829 cites W2114673368 @default.
• W2097545829 cites W2116633290 @default.
• W2097545829 cites W2119676081 @default.
• W2097545829 cites W2133479688 @default.
• W2097545829 cites W2142678320 @default.
• W2097545829 cites W2144152742 @default.
• W2097545829 cites W2145591227 @default.
• W2097545829 cites W2151365647 @default.
• W2097545829 cites W2157265156 @default.
• W2097545829 cites W2159588837 @default.
• W2097545829 cites W2165664819 @default.
• W2097545829 cites W2342908712 @default.
• W2097545829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9862717" @default.
• W2097545829 hasPublicationYear "1998" @default.
• W2097545829 type Work @default.
• W2097545829 sameAs 2097545829 @default.
• W2097545829 citedByCount "43" @default.
• W2097545829 countsByYear W20975458292012 @default.
• W2097545829 countsByYear W20975458292013 @default.
• W2097545829 countsByYear W20975458292014 @default.
• W2097545829 countsByYear W20975458292015 @default.
• W2097545829 countsByYear W20975458292016 @default.
• W2097545829 countsByYear W20975458292017 @default.
• W2097545829 countsByYear W20975458292018 @default.
• W2097545829 countsByYear W20975458292019 @default.
• W2097545829 countsByYear W20975458292020 @default.
• W2097545829 countsByYear W20975458292021 @default.
• W2097545829 countsByYear W20975458292023 @default.
• W2097545829 crossrefType "journal-article" @default.
• W2097545829 hasAuthorship W2097545829A5025526800 @default.
• W2097545829 hasAuthorship W2097545829A5045335116 @default.
• W2097545829 hasAuthorship W2097545829A5045569688 @default.
• W2097545829 hasAuthorship W2097545829A5051385259 @default.
• W2097545829 hasAuthorship W2097545829A5054325123 @default.
• W2097545829 hasAuthorship W2097545829A5061996831 @default.
• W2097545829 hasConcept C103813035 @default.
• W2097545829 hasConcept C13373296 @default.
• W2097545829 hasConcept C1491633281 @default.
• W2097545829 hasConcept C16224149 @default.
• W2097545829 hasConcept C164027704 @default.
• W2097545829 hasConcept C203014093 @default.
• W2097545829 hasConcept C2776914184 @default.
• W2097545829 hasConcept C2778690821 @default.

• next