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• W2097572673 abstract "Deficiencies of vitamin B12, B6, and folate are frequent in elderly individuals (1)(2)(3)(4), with estimated prevalences in elderly individuals of 5–40% depending on the marker for deficiency and the cutoff used (1)(2)(3)(4). Detection of a subnormal status of these B vitamins has considerable importance. Vitamin B12 deficiency in the elderly may cause cognitive dysfunction (5), neuropsychiatric disorders, dementia (6), and hyperhomocysteinemia(5), an independent risk factor for coronary vascular disease and dementia (7)(8). A 5 μmol/L increment in total plasma homocysteine (tHcy) has been associated with a 49% increase in all-cause of mortality among individuals 65–72 years of age (9).The measurement of total vitamins in serum has a limited sensitivity and specificity, especially in individuals with serum vitamin B12 <300 pmol/L (1)(3). More specific and sensitive biochemical approaches have been developed recently (10)(11). Among the biochemical markers whose concentrations are increased in vitamin B12-deficient individuals are methylmalonic acid (MMA) and tHcy, which is also increased in deficiencies of folate and vitamin B6 (1)(10).Increased MMA and tHcy have been observed in elderly individuals in spite of serum concentrations of the B vitamins within the appropriate reference intervals (1)(2). High concentrations of these metabolites were decreased by supplementation with B vitamins, which suggests pretreatment deficiency (12)(13)(14). The current study was undertaken to investigate vitamin B12 status in a group of elderly Germans, as determined by some available biochemical markers.The study population comprised 228 individuals > 65 years of age. We recruited 109 free-living elderly individuals [mean (SD) age, 79 (10) years] through use of a general practitioner’s register and 119 elderly …" @default.
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• W2097572673 date "2004-01-01" @default.
• W2097572673 modified "2023-09-24" @default.
• W2097572673 title "Vitamin B12 Status in the Elderly as Judged by Available Biochemical Markers" @default.
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• W2097572673 doi "https://doi.org/10.1373/clinchem.2003.021717" @default.
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