FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097578275> ?p ?o ?g. }

• W2097578275 abstract "Volatiles are small air-transmittable chemicals with diverse biological activities. In this study, we showed that volatiles produced by the bacterium Bacillus subtilis had a profound effect on biofilm formation of neighboring B. subtilis cells that grew in proximity but were physically separated. We further demonstrated that one such volatile, acetic acid, is particularly potent in stimulating biofilm formation. Multiple lines of genetic evidence based on B. subtilis mutants that are defective in either acetic acid production or transportation suggest that B. subtilis uses acetic acid as a metabolic signal to coordinate the timing of biofilm formation. Lastly, we investigated how B. subtilis cells sense and respond to acetic acid in regulating biofilm formation. We showed the possible involvement of three sets of genes (ywbHG, ysbAB, and yxaKC), all encoding putative holin-antiholin-like proteins, in cells responding to acetic acid and stimulating biofilm formation. All three sets of genes were induced by acetate. A mutant with a triple mutation of those genes showed a severe delay in biofilm formation, whereas a strain overexpressing ywbHG showed early and robust biofilm formation. Results of our studies suggest that B. subtilis and possibly other bacteria use acetic acid as a metabolic signal to regulate biofilm formation as well as a quorum-sensing-like airborne signal to coordinate the timing of biofilm formation by physically separated cells in the community.Volatiles are small, air-transmittable molecules produced by all kingdoms of organisms including bacteria. Volatiles possess diverse biological activities and play important roles in bacteria-bacteria and bacteria-host interactions. Although volatiles can be used as a novel and important way of cell-cell communication due to their air-transmittable nature, little is known about how the volatile-mediated signaling mechanism works. In this study, we demonstrate that the bacterium Bacillus subtilis uses one such volatile, acetic acid, as a quorum-sensing-like signal to coordinate the timing of the formation of structurally complex cell communities, also known as biofilms. We further characterized the molecular mechanisms of how B. subtilis responds to acetic acid in stimulating biofilm formation. Our study also suggests that acetic acid may be used as a volatile signal for cross-species communication." @default.
• W2097578275 created "2016-06-24" @default.
• W2097578275 creator A5036956383 @default.
• W2097578275 creator A5053013014 @default.
• W2097578275 creator A5064075650 @default.
• W2097578275 creator A5087210874 @default.
• W2097578275 date "2015-07-01" @default.
• W2097578275 modified "2023-10-17" @default.
• W2097578275 title "Acetic Acid Acts as a Volatile Signal To Stimulate Bacterial Biofilm Formation" @default.
• W2097578275 cites W1485363466 @default.
• W2097578275 cites W1490021955 @default.
• W2097578275 cites W1556554299 @default.
• W2097578275 cites W1556986896 @default.
• W2097578275 cites W1676315537 @default.
• W2097578275 cites W1852844868 @default.
• W2097578275 cites W1873765962 @default.
• W2097578275 cites W1964001208 @default.
• W2097578275 cites W1966898292 @default.
• W2097578275 cites W1967377218 @default.
• W2097578275 cites W1972452577 @default.
• W2097578275 cites W1981369081 @default.
• W2097578275 cites W1981473578 @default.
• W2097578275 cites W1991484214 @default.
• W2097578275 cites W1993621142 @default.
• W2097578275 cites W1994762646 @default.
• W2097578275 cites W1997204336 @default.
• W2097578275 cites W2001147656 @default.
• W2097578275 cites W2005237666 @default.
• W2097578275 cites W2005265983 @default.
• W2097578275 cites W2006930961 @default.
• W2097578275 cites W2007614591 @default.
• W2097578275 cites W2010554708 @default.
• W2097578275 cites W2012117313 @default.
• W2097578275 cites W2017038128 @default.
• W2097578275 cites W2018956039 @default.
• W2097578275 cites W2020496125 @default.
• W2097578275 cites W2028287684 @default.
• W2097578275 cites W2044128702 @default.
• W2097578275 cites W2052205534 @default.
• W2097578275 cites W2052638688 @default.
• W2097578275 cites W2067983754 @default.
• W2097578275 cites W2070756319 @default.
• W2097578275 cites W2070856482 @default.
• W2097578275 cites W2076165765 @default.
• W2097578275 cites W2084524312 @default.
• W2097578275 cites W2086603752 @default.
• W2097578275 cites W2090093881 @default.
• W2097578275 cites W2096604031 @default.
• W2097578275 cites W2100882223 @default.
• W2097578275 cites W2105173502 @default.
• W2097578275 cites W2106503480 @default.
• W2097578275 cites W2116364469 @default.
• W2097578275 cites W2116886737 @default.
• W2097578275 cites W2120160920 @default.
• W2097578275 cites W2121651883 @default.
• W2097578275 cites W2123364281 @default.
• W2097578275 cites W2125281419 @default.
• W2097578275 cites W2125421309 @default.
• W2097578275 cites W2127839426 @default.
• W2097578275 cites W2133106092 @default.
• W2097578275 cites W2134301019 @default.
• W2097578275 cites W2142138683 @default.
• W2097578275 cites W2143160816 @default.
• W2097578275 cites W2143768216 @default.
• W2097578275 cites W2144529284 @default.
• W2097578275 cites W2148423248 @default.
• W2097578275 cites W2152042119 @default.
• W2097578275 cites W2152875113 @default.
• W2097578275 cites W2154137871 @default.
• W2097578275 cites W2157962844 @default.
• W2097578275 cites W2160712199 @default.
• W2097578275 cites W2164450667 @default.
• W2097578275 cites W2164658986 @default.
• W2097578275 cites W2166516091 @default.
• W2097578275 cites W2167240777 @default.
• W2097578275 cites W2168882890 @default.
• W2097578275 doi "https://doi.org/10.1128/mbio.00392-15" @default.
• W2097578275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4462622" @default.
• W2097578275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26060272" @default.
• W2097578275 hasPublicationYear "2015" @default.
• W2097578275 type Work @default.
• W2097578275 sameAs 2097578275 @default.
• W2097578275 citedByCount "74" @default.
• W2097578275 countsByYear W20975782752015 @default.
• W2097578275 countsByYear W20975782752016 @default.
• W2097578275 countsByYear W20975782752017 @default.
• W2097578275 countsByYear W20975782752018 @default.
• W2097578275 countsByYear W20975782752019 @default.
• W2097578275 countsByYear W20975782752020 @default.
• W2097578275 countsByYear W20975782752021 @default.
• W2097578275 countsByYear W20975782752022 @default.
• W2097578275 countsByYear W20975782752023 @default.
• W2097578275 crossrefType "journal-article" @default.
• W2097578275 hasAuthorship W2097578275A5036956383 @default.
• W2097578275 hasAuthorship W2097578275A5053013014 @default.
• W2097578275 hasAuthorship W2097578275A5064075650 @default.
• W2097578275 hasAuthorship W2097578275A5087210874 @default.
• W2097578275 hasBestOaLocation W20975782753 @default.
• W2097578275 hasConcept C104317684 @default.
• W2097578275 hasConcept C118687296 @default.

• next