FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097580944> ?p ?o ?g. }

• W2097580944 endingPage "4585" @default.
• W2097580944 startingPage "4578" @default.
• W2097580944 abstract "Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway participates in many cellular processes, including cell survival and differentiation, and also has been shown to play important roles in different steps of the life cycles of a variety of viruses. Here we report that the inhibition of the PI3K/Akt pathway inhibited budding and to a lesser extent RNA synthesis, but not cell entry, of LCMV. Accordingly, BEZ-235, a PI3K inhibitor currently in cancer clinical trials, inhibited LCMV multiplication in cultured cells. These findings, together with those previously reported for Junin virus (JUNV), indicate that targeting the PI3K/Akt pathway could represent a novel antiviral strategy to combat human-pathogenic arenaviruses." @default.
• W2097580944 created "2016-06-24" @default.
• W2097580944 creator A5035095483 @default.
• W2097580944 creator A5048194385 @default.
• W2097580944 creator A5061615595 @default.
• W2097580944 date "2012-04-15" @default.
• W2097580944 modified "2023-10-16" @default.
• W2097580944 title "The PI3K/Akt Pathway Contributes to Arenavirus Budding" @default.
• W2097580944 cites W1548813007 @default.
• W2097580944 cites W1964940884 @default.
• W2097580944 cites W1981711832 @default.
• W2097580944 cites W1984879511 @default.
• W2097580944 cites W1991589508 @default.
• W2097580944 cites W2003497053 @default.
• W2097580944 cites W2004228578 @default.
• W2097580944 cites W2013131355 @default.
• W2097580944 cites W2026972377 @default.
• W2097580944 cites W2027868702 @default.
• W2097580944 cites W2028733896 @default.
• W2097580944 cites W2032417358 @default.
• W2097580944 cites W2039628288 @default.
• W2097580944 cites W2042487525 @default.
• W2097580944 cites W2053674165 @default.
• W2097580944 cites W2060818930 @default.
• W2097580944 cites W2064497478 @default.
• W2097580944 cites W2074834651 @default.
• W2097580944 cites W2076707613 @default.
• W2097580944 cites W2085605782 @default.
• W2097580944 cites W2086084004 @default.
• W2097580944 cites W2091231062 @default.
• W2097580944 cites W2092267439 @default.
• W2097580944 cites W2095967124 @default.
• W2097580944 cites W2099418758 @default.
• W2097580944 cites W2107606990 @default.
• W2097580944 cites W2112147503 @default.
• W2097580944 cites W2113826880 @default.
• W2097580944 cites W2119415830 @default.
• W2097580944 cites W2130276289 @default.
• W2097580944 cites W2137625244 @default.
• W2097580944 cites W2137840845 @default.
• W2097580944 cites W2144314464 @default.
• W2097580944 cites W2147264723 @default.
• W2097580944 cites W2150114245 @default.
• W2097580944 cites W2155009617 @default.
• W2097580944 cites W2167181710 @default.
• W2097580944 cites W2168882041 @default.
• W2097580944 doi "https://doi.org/10.1128/jvi.06604-11" @default.
• W2097580944 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3318602" @default.
• W2097580944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22345463" @default.
• W2097580944 hasPublicationYear "2012" @default.
• W2097580944 type Work @default.
• W2097580944 sameAs 2097580944 @default.
• W2097580944 citedByCount "49" @default.
• W2097580944 countsByYear W20975809442012 @default.
• W2097580944 countsByYear W20975809442013 @default.
• W2097580944 countsByYear W20975809442014 @default.
• W2097580944 countsByYear W20975809442015 @default.
• W2097580944 countsByYear W20975809442016 @default.
• W2097580944 countsByYear W20975809442017 @default.
• W2097580944 countsByYear W20975809442018 @default.
• W2097580944 countsByYear W20975809442019 @default.
• W2097580944 countsByYear W20975809442020 @default.
• W2097580944 countsByYear W20975809442021 @default.
• W2097580944 countsByYear W20975809442022 @default.
• W2097580944 countsByYear W20975809442023 @default.
• W2097580944 crossrefType "journal-article" @default.
• W2097580944 hasAuthorship W2097580944A5035095483 @default.
• W2097580944 hasAuthorship W2097580944A5048194385 @default.
• W2097580944 hasAuthorship W2097580944A5061615595 @default.
• W2097580944 hasBestOaLocation W20975809441 @default.
• W2097580944 hasConcept C140704245 @default.
• W2097580944 hasConcept C147483822 @default.
• W2097580944 hasConcept C159047783 @default.
• W2097580944 hasConcept C167672396 @default.
• W2097580944 hasConcept C203014093 @default.
• W2097580944 hasConcept C2522874641 @default.
• W2097580944 hasConcept C2775955205 @default.
• W2097580944 hasConcept C2777427142 @default.
• W2097580944 hasConcept C2779574689 @default.
• W2097580944 hasConcept C2780190958 @default.
• W2097580944 hasConcept C58475186 @default.
• W2097580944 hasConcept C62478195 @default.
• W2097580944 hasConcept C75217442 @default.
• W2097580944 hasConcept C86554907 @default.
• W2097580944 hasConcept C86803240 @default.
• W2097580944 hasConcept C95444343 @default.
• W2097580944 hasConceptScore W2097580944C140704245 @default.
• W2097580944 hasConceptScore W2097580944C147483822 @default.
• W2097580944 hasConceptScore W2097580944C159047783 @default.
• W2097580944 hasConceptScore W2097580944C167672396 @default.
• W2097580944 hasConceptScore W2097580944C203014093 @default.
• W2097580944 hasConceptScore W2097580944C2522874641 @default.
• W2097580944 hasConceptScore W2097580944C2775955205 @default.
• W2097580944 hasConceptScore W2097580944C2777427142 @default.
• W2097580944 hasConceptScore W2097580944C2779574689 @default.
• W2097580944 hasConceptScore W2097580944C2780190958 @default.
• W2097580944 hasConceptScore W2097580944C58475186 @default.
• W2097580944 hasConceptScore W2097580944C62478195 @default.

• next